Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0131 Transporter Info
Gene Name	SLC1A3
Transporter Name	Excitatory amino acid transporter 1
Gene ID	6507
UniProt ID	P43003

Post-Translational Modification of This DT
Overview ofSLC1A3 Modification Sites with Functional and Structural Information
Sequence	M T K S N G E E P K M G G R M E R F Q Q G V R K R T L L A K K K V Q N I T K E D V K S Y L F R N A F V L L T V T A V I V G T I L G F T L R P Y R M S Y R E V K Y F S F P G E L L M R M L Q M L V L P L I I S S L V T G M A A L D S K A S G K M G M R A V V Y Y M T T T I I A V V I G I I I V I I I H P G K G T K E N M H R E G K I V R V T A A D A F L D L I R N M F P P N L V E A C F K Q F K T N Y E K R S F K V P I Q A N E T L V G A V I N N V S E A M E T L T R I T E E L V P V P G S V N G V N A L G L V V F S M C F G F V I G N M K E Q G Q A L R E F F D S L N E A I M R L V A V I M W Y A P V G I L F L I A G K I V E M E D M G V I G G Q L A M Y T V T V I V G L L I H A V I V L P L L Y F L V T R K N P W V F I G G L L Q A L I T A L G T S S S S A T L P I T F K C L E E N N G V D K R V T R F V L P V G A T I N M D G T A L Y E A L A A I F I A Q V N N F E L N F G Q I I T I S I T A T A A S I G A A G I P Q A G L V T M V I V L T S V G L P T D D I T L I I A V D W F L D R L R T T T N V L G D S L G A G I V E H L S R H E L K N R D V E M G N S V I E E N E M K K P Y Q L I A Q D N E T E K P I D S E T K M
PTM type	X-Acetylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A3			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	38
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC1A3 Lysine 38 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC1A3			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	521
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC1A3 Lysine 521 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A3			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	186
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC1A3 Cystine 186 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC1A3			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	375
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC1A3 Cystine 375 has the potential to affect its expression or activity.
Phosphorylation
Serine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	4
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Serine 4 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC1A3			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	512
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Serine 512 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC1A3			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	538
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Serine 538 has the potential to affect its expression or activity.
Threonine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A3			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 2 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC1A3			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	26
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 26 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC1A3			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	67
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 67 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC1A3			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	223
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 223 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC1A3			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	228
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 228 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC1A3			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	482
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 482 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC1A3			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	532
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 532 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC1A3			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	540
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Threonine 540 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A3			[5], [12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	523
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A3 Tyrosine 523 has the potential to affect its expression or activity.
Ubiquitination
Lysine	25 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	3
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 3 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	3
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 3 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	3
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 3 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 10 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 10 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 10 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 10 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	31
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 31 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	31
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 31 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	32
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 32 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	32
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 32 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	32
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 32 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	191
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 191 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	191
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 191 has the potential to affect its expression or activity.
PTM Phenomenon15	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 384 has the potential to affect its expression or activity.
PTM Phenomenon16	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 384 has the potential to affect its expression or activity.
PTM Phenomenon17	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 384 has the potential to affect its expression or activity.
PTM Phenomenon18	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 384 has the potential to affect its expression or activity.
PTM Phenomenon19	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 384 has the potential to affect its expression or activity.
PTM Phenomenon20	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 384 has the potential to affect its expression or activity.
PTM Phenomenon21	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 384 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence SLC1A3			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	520
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 520 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence SLC1A3			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	521
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 521 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence SLC1A3			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	534
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 534 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence SLC1A3			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	541
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A3 Lysine 541 has the potential to affect its expression or activity.

References
1	Regulation of cellular metabolism by protein lysine acetylation. Science. 2010 Feb 19;327(5968):1000-4.
2	Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Mol Cell. 2015 Sep 3;59(5):867-81.
3	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
4	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
5	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
6	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
7	Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis. Methods. 2012 Feb;56(2):268-74.
8	Phosphoproteome of human glioblastoma initiating cells reveals novel signaling regulators encoded by the transcriptome. PLoS One. 2012;7(8):e43398.
9	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
10	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
11	Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. J Neurochem. 2003 Sep;86(5):1181-8.
12	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
13	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
14	Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J Proteome Res. 2012 Feb 3;11(2):796-807.

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Detail Information of Post-Translational Modifications

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