Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0131 Transporter Info
Gene Name	SLC1A3
Transporter Name	Excitatory amino acid transporter 1
Gene ID	6507
UniProt ID	P43003

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A3 gene in glioblastoma multiforme condition			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC1A3 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Excitatory amino acid transporter 1.
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in breast cancer bone metastasis condition			[2]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC1A3 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A3 gene in K562 cells			[5]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC1A3 gene in K562 cells, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in breast cancer condition			[6]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC1A3 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in breast cancer condition			[6]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC1A3 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in hepatocellular carcinoma condition			[7]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Affected Drug/Substrate	Glutamate
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human childhood hepatocellular carcinoma cells (Hep3B)
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of SLC1A3 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
HIF1A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in hepatocellular carcinoma condition			[7]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Affected Drug/Substrate	Glutamate
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human childhood hepatocellular carcinoma cells (Hep3B)
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC1A3 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[8]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Bone marrow; Brain; Breast; Cervix; Colon; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in melanoma condition			[9]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC1A3 gene in melanoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[10]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[10]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A3 gene in prostate cancer condition			[11]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC1A3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A3 gene in health condition			[12]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC1A3 gene in health condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
VDR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in leukemia condition			[13]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Affected Drug/Substrate	1a,25-dihydroxyvitamin D3
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC1A3 gene in leukemia condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
Transcriptional Phenomenon2	Binding to SLC1A3 gene in THP1 cells			[14]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC1A3 gene in THP1 cells, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[4]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in gastric cancer condition			[15]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC1A3 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in gastric cancer condition			[15]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC1A3 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[3]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Striated muscle
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A3 gene in erythroleukemia condition			[16]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC1A3 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[8]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in astrocytoma condition			[17]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Affected Drug/Substrate	Glutamate
Studied Phenotype	Astrocytoma [ICD11: 2A00.0Y]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Human astrocytoma cells (H4)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC1A3 gene in astrocytoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
SP3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in astrocytoma condition			[17]
TF Protein Name	Transcription factor Sp3		Transcription Factor Info
Affected Drug/Substrate	Glutamate
Studied Phenotype	Astrocytoma [ICD11: 2A00.0Y]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Human astrocytoma cells (H4)
Detailed Description	Transcription factor Sp3 (SP3) has been reported to activate the transcription of SLC1A3 gene in astrocytoma condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A3 gene in health condition			[18]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	down regulating
Experimental Material	YY1-loxP homozygous mice astrocytes
Detailed Description	Transcriptional repressor protein YY1 (YY1), influenced by the exogenous manganese chloride, has been reported to repress the transcription of SLC1A3 gene in health condition , which leads to a decreased expression of the drug transporter Excitatory amino acid transporter 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[10]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in multiple human cancer types condition			[19]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC1A3 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
NANOG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in embryonic stem cells condition			[20]
TF Protein Name	Homeobox protein NANOG		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC1A3 gene in embryonic stem cells condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in ovarian cancer condition			[21]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC1A3 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[3]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[4]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in lung cancer condition			[22]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Studied Phenotype	Lung cancer [ICD11: 2C25]
Tissue	Bronchus
Related DT Changes	Up regulating
Experimental Material	Human bronchus epithelial cells (16HBE14o-)
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to activate the transcription of SLC1A3 gene in lung cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in breast cancer condition			[23]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC1A3 gene in breast cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[10]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
FLI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A3 gene in megakaryocytes condition			[24]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC1A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
Transcriptional Phenomenon2	Direct binding to SLC1A3 gene			[3]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[8]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[8]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[4]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[8]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
TF Superclass6: Immunoglobulin fold
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in glioblastoma multiforme condition			[25]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC1A3 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A3 gene in epithelial to mesenchymal transition condition			[26]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC1A3 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
Transcriptional Phenomenon2	Binding to SLC1A3 gene in health condition			[27]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC1A3 gene in health condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in prostate cancer condition			[28]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC1A3 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A3 gene			[10]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC1A3 gene, which in turn affects the expression or function of the drug transporter Excitatory amino acid transporter 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
SMAD3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A3 gene in HaCaT keratinocytes condition			[29]
TF Protein Name	Mothers against decapentaplegic homolog 3		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of SLC1A3 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Excitatory amino acid transporter 1.
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A3 gene in epithelial ovarian cancer condition			[30]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC1A3 gene in epithelial ovarian cancer condition, which leads to an increased expression of the drug transporter Excitatory amino acid transporter 1.

References
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2	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
3	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5	c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
6	High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
7	Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014 Oct 15;5(19):8853-68.
8	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-165. (ID:ENSG00000079215)
9	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
10	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
11	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
12	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
13	Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
14	Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
15	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
16	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
17	Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes. J Neurochem. 2003 Dec;87(6):1485-98.
18	Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 Nov 13;295(46):15662-15676.
19	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
20	Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
21	Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
22	Targeted metabolomics analysis identified the role of FOXA1 in the change in glutamate-glutamine metabolic pattern of BaP malignantly transformed 16HBE cells. Toxicol Appl Pharmacol. 2023 Feb 15;461:116402.
23	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
24	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
25	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
26	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
27	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
28	Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
29	Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.
30	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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