Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0131 Transporter Info
Gene Name	SLC1A3
Transporter Name	Excitatory amino acid transporter 1
Gene ID	6507
UniProt ID	P43003

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC1A3 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A3 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A3 protein			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC1A3 promoter			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased expression of SLC1A3 protein			[36]
Regulation Mechanism				Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SLC1A3 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
2,4,5,2',4',5'-hexachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC1A3 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of SLC1A3 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC1A3 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
belinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC1A3 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC1A3 protein			[26]
Regulation Mechanism				Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol AF results in increased expression of SLC1A3 protein			[38]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC1A3 gene			[39]
Regulation Mechanism				Transcription Factor Info
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC1A3 mRNA affects the susceptibility to Cisplatin			[40]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC1A3 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC1A3 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	coumarin results in decreased phosphorylation of SLC1A3 protein			[43]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of SLC1A3 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
manganese chloride	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in decreased expression of SLC1A3 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	manganese chloride results in decreased expression of SLC1A3 protein			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A3 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A3 protein			[16]
Regulation Mechanism				Transcription Factor Info
mono-(2-ethylhexyl)phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mono-(2-ethylhexyl)phthalate results in decreased expression of SLC1A3 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
monomethylarsonous acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in increased expression of SLC1A3 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC1A3 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid results in decreased phosphorylation of SLC1A3 protein			[47]
Regulation Mechanism				Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in increased expression of SLC1A3 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of SLC1A3 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC1A3 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased expression of SLC1A3 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in increased expression of SLC1A3 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of SLC1A3 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC1A3 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC1A3 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
Approved Drug
L-glutamic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-glutamic acid inhibits the transportation of D-Aspartate by SLC1A3			[1]
Affected Drug/Substrate	D-Aspartate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-EAAT1
Manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Manganese chloride inhibits the expression of SLC1A3			[2]
Regulation Mechanism	via enhancement of Transcriptional repressor protein YY1 (YY1)			Transcription Factor Info
Cell System	YY1-loxP homozygous mice astrocytes
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC1A3			[3]
Medroxyprogesterone Acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Medroxyprogesterone Acetate increases the expression of SLC1A3			[4]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLC1A3			[5]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC1A3			[6]
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone inhibits the expression of SLC1A3			[7]
Panobinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Panobinostat increases the expression of SLC1A3			[8]
Vorinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vorinostat increases the expression of SLC1A3			[8]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLC1A3			[9]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC1A3			[10]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC1A3			[11]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC1A3			[12]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC1A3			[13]
Testosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone increases the expression of SLC1A3			[14]
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiodarone increases the expression of SLC1A3			[15]
Valproic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC1A3			[16]
Etanercept	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etanercept induces the activity of SLC1A3			[17]
Drug in Phase 3 Trial
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC1A3			[24]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulforafan increases the expression of SLC1A3			[25]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the expression of SLC1A3			[23]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC1A3			[26]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC1A3			[27]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC1A3			[8]
Investigative Drug
UCPH-101	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	UCPH-101 inhibits the activity of SLC1A3			[29]
DL-TBOA	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DL-TBOA inhibits the activity of SLC1A3			[30]
Natural Product
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coal Ash inhibits the expression of SLC1A3			[18]
Cholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholesterol increases the expression of SLC1A3			[22]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC1A3			[28]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin affects the expression of SLC1A3			[20]
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC1A3			[19]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC1A3			[21]

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Detail Information of Exogenous Modulation

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