Drug Transporter (DT) Information

General Information of DT
DT ID DTD0107
Gene Name SLC16A3
Protein Name Monocarboxylate transporter 4
Gene ID
9123
UniProt ID
O15427
TCDB ID
2.A.1.13.6
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:7BP3_A

Identity:45.61%

Minimized Score:-944.326 kcal/mol

Detail: Structure Info

Synonyms MCT 4; MCT4; SLC16A3; Solute carrier family 16 member 3
DT Family Major Facilitator Superfamily (MFS)
Monocarboxylate Transporter (MCT) Family
Tissue Specificity Highly expressed in skeletal muscle.
Function This proton-linked monocarboxylate transporter catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Endogenous Substrate(s) Monocarboxylates; Lactate; pyruvate; Branched-chain oxo acids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Monocarboxylate transporter 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Monocarboxylate transporter 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Monocarboxylate transporter 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Monocarboxylate transporter 4
Microbiota Influence (MBI)

(β) Post-translational Modification of Monocarboxylate transporter 4
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Monocarboxylate transporter 4
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Monocarboxylate transporter 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Monocarboxylate transporter 4
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Monocarboxylate transporter 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Monocarboxylate transporter 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
L-lactate
5460161
EM Info Identified using MCT4-attenuated mice [1]

Drug-DT Affinity Assessed by Cell Line

 Investigative Drug

 Click to Show/Hide the Full List of Drug:           3 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Milchsaure Investigative Drug Info Oocytes-MCT4 Km =28 microM [2]
Milchsaure Investigative Drug Info Oocytes-MCT4 Km =28 microM [2]
Milchsaure Investigative Drug Info Oocytes-MCT4 Km =28 microM [2]
References
1 GPR55 receptor antagonist decreases glycolytic activity in PANC-1 pancreatic cancer cell line and tumor xenografts. Int J Cancer. 2017 Nov 15;141(10):2131-2142.
2 Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93.

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