Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0107 Transporter Info
Gene Name	SLC16A3
Transporter Name	Monocarboxylate transporter 4
Gene ID	9123
UniProt ID	O15427

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Tretinoin co-treated with Arsenic Trioxide results in increased expression of SLC16A3 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Decitabine affects the expression of SLC16A3 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cyclosporine results in decreased methylation of SLC16A3 promoter			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol binds to ESR2 protein which results in increased expression of SLC16A3 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol results in increased expression of SLC16A3 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC16A3 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid results in increased methylation of SLC16A3 gene			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC16A3 5' UTR			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLC16A3 promoter			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of SLC16A3 3' UTR			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Benzo(a)pyrene results in increased methylation of SLC16A3 exon			[40]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of SLC16A3 mRNA			[23]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC16A3 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
acipimox	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	acipimox results in increased expression of SLC16A3 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Acrolein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin co-treated with Arsenic Trioxide results in increased expression of SLC16A3 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Asbestos, Serpentine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Serpentine results in increased expression of SLC16A3 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
beta-lapachone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-lapachone results in decreased expression of SLC16A3 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	beta-lapachone results in increased expression of SLC16A3 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
bisphenol A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC16A3 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC16A3 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in increased expression of SLC16A3 protein			[43]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F co-treated with Fulvestrant results in increased methylation of SLC16A3 gene			[44]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in decreased expression of SLC16A3 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
bruceine D	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bruceine D affects the reaction Oxygen deficiency affects the expression of SLC16A3 protein			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	CTNNBIP1 protein affects the reaction bruceine D affects the reaction Oxygen deficiency affects the expression of SLC16A3 protein			[46]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A3 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased expression of SLC16A3 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC16A3 gene			[49]
Regulation Mechanism				Transcription Factor Info
chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chloropicrin results in decreased expression of SLC16A3 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of SLC16A3 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	zinc chloride inhibits the reaction cobaltous chloride results in increased expression of SLC16A3 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	coumarin results in decreased phosphorylation of SLC16A3 protein			[51]
Regulation Mechanism				Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC16A3 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC16A3 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
erucylphospho-N,N,N-trimethylpropylammonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of SLC16A3 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FR900359 results in increased phosphorylation of SLC16A3 protein			[57]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F co-treated with Fulvestrant results in increased methylation of SLC16A3 gene			[44]
Regulation Mechanism				Transcription Factor Info
Furaldehyde	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furaldehyde co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in decreased expression of SLC16A3 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Lactic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC16A3 protein affects the reaction Lactic Acid results in decreased expression of SEMA3A protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC16A3 protein affects the reaction Lactic Acid results in increased expression of CD274 protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC16A3 protein affects the reaction Lactic Acid results in increased expression of HIF1A protein			[59]
Regulation Mechanism				Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased expression of SLC16A3 mRNA			[5]
Regulation Mechanism				Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in decreased expression of SLC16A3 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC16A3 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
N-Nitrosopyrrolidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-Nitrosopyrrolidine results in increased expression of SLC16A3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC16A3 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
Oxygen	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bruceine D affects the reaction Oxygen deficiency affects the expression of SLC16A3 protein			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	CTNNBIP1 protein affects the reaction bruceine D affects the reaction Oxygen deficiency affects the expression of SLC16A3 protein			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Oxygen deficiency affects the expression of SLC16A3 protein			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Oxygen deficiency results in increased expression of SLC16A3 mRNA			[5]
Regulation Mechanism				Transcription Factor Info
Ozone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Air Pollutants results in increased abundance of Ozone which affects the expression of SLC16A3 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Volatile Organic Compounds co-treated with Ozone results in decreased expression of SLC16A3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
PF-06840003	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PF-06840003 inhibits the reaction MAPT protein mutant form results in decreased expression of SLC16A3 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
potassium chromate(VI)	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC16A3 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in decreased expression of SLC16A3 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
pyrogallol 1,3-dimethyl ether	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furaldehyde co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC16A3 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of SLC16A3 gene			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of SLC16A3 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
Sodium Chloride	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in decreased expression of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC16A3 protein			[58]
Regulation Mechanism				Transcription Factor Info
tamibarotene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tamibarotene results in increased expression of SLC16A3 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC16A3 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A3 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC16A3 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
Triiodothyronine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triiodothyronine results in increased expression of SLC16A3 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC16A3 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of SLC16A3 mRNA			[8]
Regulation Mechanism				Transcription Factor Info
zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chloride inhibits the reaction cobaltous chloride results in increased expression of SLC16A3 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the activity of SLC16A3			[2]
Cell System	Human enterocyte-like 2 cell (Caco-2)-MCT4
Liothyronine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Liothyronine increases the expression of SLC16A3			[3]
Regulation Mechanism	via enhancement of Hypoxia-inducible factor 1-alpha (HIF1A)			Transcription Factor Info
Cell System	Human skin fibroblasts
Tretinoin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLC16A3			[4]
Manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Manganese chloride increases the expression of SLC16A3			[5]
Decitabine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of SLC16A3			[6]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC16A3			[7]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC16A3			[8]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of SLC16A3			[8]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC16A3			[9]
Cytarabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cytarabine inhibits the expression of SLC16A3			[10]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC16A3			[11]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin affects the expression of SLC16A3			[12]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the expression of SLC16A3			[13]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC16A3			[14]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of SLC16A3			[15]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin affects the expression of SLC16A3			[16]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of SLC16A3			[17]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC16A3			[18]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC16A3			[19]
Irbesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irbesartan inhibits the activity of SLC16A3			[20]
Drug in Phase 2/3 Trial
AM-80	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AM-80 increases the expression of SLC16A3			[4]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC16A3			[22]
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC16A3			[22]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC16A3			[27]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin increases the expression of SLC16A3			[11]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC16A3			[24]
Investigative Drug
Manganese	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Manganese increases the expression of SLC16A3			[5]
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG-001 inhibits the expression of SLC16A3			[25]
Natural Product
Butyric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyric acid induces the transportation of Ferulic acid by SLC16A3			[1]
Affected Drug/Substrate	Ferulic acid	Modulation Type	Inducer
Cell System	Human enterocyte-like 2 cell (Caco-2)-MCT4
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC16A3			[29]
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Jinfukang increases the expression of SLC16A3			[28]
Biotoxin
Dinophysistoxin 1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dinophysistoxin 1 increases the expression of SLC16A3			[30]
dinophysistoxin 1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dinophysistoxin 1 results in increased expression of SLC16A3 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Chloropicrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloropicrin inhibits the expression of SLC16A3			[26]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the expression of SLC16A3			[32]
Carcinogen
Benzo(a)pyrene	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC16A3			[9]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic results in increased ubiquitination of SLC16A3 protein			[36]
Regulation Mechanism				Transcription Factor Info
Benzene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzene results in increased expression of SLC16A3 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A3 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of SLC16A3 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of SLC16A3			[23]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of SLC16A3			[31]
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atrazine increases the expression of SLC16A3			[21]

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