Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0107 Transporter Info | ||||
Gene Name | SLC16A3 | ||||
Transporter Name | Monocarboxylate transporter 4 | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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BACH1 |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in breast cancer bone metastasis condition | [1] | ||||
TF Protein Name |
Transcription regulator protein BACH1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC16A3 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
CEBPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein alpha | Transcription Factor Info | ||||
Tissue |
Blood; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
CEBPB |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in ovarian cancer condition | [3] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein beta | Transcription Factor Info | ||||
Studied Phenotype |
Ovarian cancer [ICD11: 2C73] | |||||
Tissue |
Ovary | |||||
Related DT Changes |
Up regulating | |||||
Experimental Material |
BALB/c mice | |||||
Detailed Description |
CCAAT/enhancer-binding protein beta (CEBPB) has been reported to activate the transcription of SLC16A3 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
CEBPD |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein delta | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Embryo; Liver; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
JUND |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Transcription factor JunD | Transcription Factor Info | ||||
Tissue |
Bone marrow; Brain; Cervix; Colon; Coronary artery; Embryo; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor JunD (JUND) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class1.2: Basic helix-loop-helix factors |
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ARNT |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Aryl hydrocarbon receptor nuclear translocator | Transcription Factor Info | ||||
Tissue |
Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
BHLHE40 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Class E basic helix-loop-helix protein 40 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
HIF1A |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in health condition | [7] | ||||
TF Protein Name |
Hypoxia-inducible factor 1-alpha | Transcription Factor Info | ||||
Studied Phenotype |
Heallth [ICD11: N.A] | |||||
Tissue |
Lumbar intervertebral disc | |||||
Related DT Changes |
Up regulating | |||||
Experimental Material |
human lumbar intervertebral discs cell isolates | |||||
Detailed Description |
Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC16A3 gene in health condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
MYC |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in embryonic stem cells condition | [8] | ||||
TF Protein Name |
Myc proto-oncogene protein | Transcription Factor Info | ||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Myc proto-oncogene protein (MYC) has been reported to activate the transcription of SLC16A3 gene in embryonic stem cells condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
MYOD1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Myoblast determination protein 1 | Transcription Factor Info | ||||
Tissue |
Myotube | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myoblast determination protein 1 (MYOD1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
TCF12 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Transcription factor 12 | Transcription Factor Info | ||||
Tissue |
Blood; Embryo; Liver; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor 12 (TCF12) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
TCF21 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [9] | ||||
TF Protein Name |
Transcription factor 21 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor 21 (TCF21) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
TCF3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Transcription factor E2-alpha | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2-alpha (TCF3) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
USF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Upstream stimulatory factor 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Brain; Embryo; Liver; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Upstream stimulatory factor 1 (USF1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
USF2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Upstream stimulatory factor 2 | Transcription Factor Info | ||||
Tissue |
Embryo; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Upstream stimulatory factor 2 (USF2) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class1.3: Basic helix-span-helix factors |
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TFAP2A |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Transcription factor AP-2-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
TFAP2C |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Transcription factor AP-2 gamma | Transcription Factor Info | ||||
Tissue |
Breast; Cervix; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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ESR1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Estrogen receptor | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Estrogen receptor (ESR1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ESRRA |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Steroid hormone receptor ERR1 | Transcription Factor Info | ||||
Tissue |
Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Steroid hormone receptor ERR1 (ESRRA) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
HNF4A |
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Transcriptional Phenomenon1 |
Binding to SLC16A3 gene in health condition | [10] | ||||
TF Protein Name |
Hepatocyte nuclear factor 4-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC16A3 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
PGR |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Progesterone receptor | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Progesterone receptor (PGR) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
PPARD |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in myofibroblasts condition | [11] | ||||
TF Protein Name |
Peroxisome proliferator-activated receptor delta | Transcription Factor Info | ||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of SLC16A3 gene in myofibroblasts condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
RXRG |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Retinoic acid receptor RXR-gamma | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
VDR |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in leukemia condition | [12] | ||||
TF Protein Name |
Vitamin D3 receptor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC16A3 gene in leukemia condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
Class2.3: C2H2 zinc finger factors |
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BCL6 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
B-cell lymphoma 6 protein | Transcription Factor Info | ||||
Tissue |
Blood; Tonsil | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
CTCF |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
CTCFL |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Transcriptional repressor CTCFL | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
EGR1 |
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Transcriptional Phenomenon1 |
Binding to SLC16A3 gene in erythroleukemia condition | [13] | ||||
TF Protein Name |
Early growth response protein 1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC16A3 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
KLF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Krueppel-like factor 1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 1 (KLF1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
KLF5 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Krueppel-like factor 5 | Transcription Factor Info | ||||
Tissue |
Colon; Pancreatic ductal; Stomach | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 5 (KLF5) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
KLF9 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Krueppel-like factor 9 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 9 (KLF9) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
MAZ |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
WT1 |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in podocyte condition | [14] | ||||
TF Protein Name |
Wilms tumor protein | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Wilms tumor protein (WT1) has been reported to activate the transcription of SLC16A3 gene in podocyte condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
YY1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Transcriptional repressor protein YY1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Brain; Colon; Liver; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ZBTB7A |
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Transcriptional Phenomenon1 |
Repression of SLC16A3 gene in colon cancer condition | [15] | ||||
TF Protein Name |
Zinc finger and BTB domain-containing protein 7A | Transcription Factor Info | ||||
Studied Phenotype |
Colon cancer [ICD11: 2B90] | |||||
Tissue |
Colon | |||||
Related DT Changes |
Down regulating | |||||
Experimental Material |
Human colon carcinoma cells (HCT-116) | |||||
Detailed Description |
Zinc finger and BTB domain-containing protein 7A (ZBTB7A) has been reported to repress the transcription of SLC16A3 gene in colon cancer condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 4. | |||||
ZFX |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Zinc finger X-chromosomal protein | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger X-chromosomal protein (ZFX) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ZNF263 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Zinc finger protein 263 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 263 (ZNF263) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ZNF384 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Zinc finger protein 384 | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 384 (ZNF384) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class3.1: Homeo domain factors |
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PBX1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
PBX3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 3 | Transcription Factor Info | ||||
Tissue |
Blood; Brain; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
POU2F1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
POU domain, class 2, transcription factor 1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
SIX5 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Homeobox protein SIX5 | Transcription Factor Info | ||||
Tissue |
Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Homeobox protein SIX5 (SIX5) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ZEB1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Zinc finger E-box-binding homeobox 1 | Transcription Factor Info | ||||
Tissue |
Blood; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class3.2: Paired box factors |
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PAX5 |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Paired box protein Pax-5 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Paired box protein Pax-5 (PAX5) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
E2F6 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Transcription factor E2F6 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Cervix; Embryo; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F6 (E2F6) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
E2F7 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Transcription factor E2F7 | Transcription Factor Info | ||||
Tissue |
Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F7 (E2F7) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
FOXA1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
FOXA2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC16A3 gene | [10] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-beta | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC16A3 gene in . condition, which leads to a affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
FOXP1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Forkhead box protein P1 | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Forkhead box protein P1 (FOXP1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class3.5: Tryptophan cluster factors |
Click to Show/Hide the Full List of 10 TF(s) Regulating This DT |
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ELF1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
ETS-related transcription factor Elf-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Breast; Liver; Lung; Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ELK1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
ETS domain-containing protein Elk-1 | Transcription Factor Info | ||||
Tissue |
Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS domain-containing protein Elk-1 (ELK1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ELK3 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding of SLC16A3 gene in cancer condition | [16] | ||||
TF Protein Name |
ETS domain-containing protein Elk-3 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC16A3 gene in cancer condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
ETS domain-containing protein Elk-3 | Transcription Factor Info | ||||
Tissue |
Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ETS1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Protein C-ets-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-1 (ETS1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
ETV1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
ETS translocation variant 1 | Transcription Factor Info | ||||
Tissue |
Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS translocation variant 1 (ETV1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
FLI1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC16A3 gene in megakaryocytes condition | [17] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC16A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
GABPA |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
GA-binding protein alpha chain | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
GA-binding protein alpha chain (GABPA) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
IRF1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Interferon regulatory factor 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Pancreatic ductal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Interferon regulatory factor 1 (IRF1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
MYB |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Transcriptional activator Myb | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional activator Myb (MYB) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
SPI1 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC16A3 gene in acute promyelocytic leukemia condition | [18] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC16A3 gene in acute promyelocytic leukemia condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class4.1: High-mobility group domain factors |
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SOX2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of SLC16A3 gene in prostate cancer condition | [19] | ||||
TF Protein Name |
Transcription factor SOX-2 | Transcription Factor Info | ||||
Studied Phenotype |
Prostate cancer [ICD11: 2C82] | |||||
Tissue |
Prostate | |||||
Related DT Changes |
Up regulating | |||||
Experimental Material |
human prostate cancer cell isolates | |||||
Detailed Description |
Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC16A3 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 4. | |||||
Class4.2: Heteromeric CCAAT-binding factors |
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NFYA |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Nuclear transcription factor Y subunit alpha | Transcription Factor Info | ||||
Tissue |
Bone marrow; Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class5.1: MADS box factors |
Click to Show/Hide the Full List of 1 TF(s) Regulating This DT |
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SRF |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Serum response factor | Transcription Factor Info | ||||
Tissue |
Blood; Embryo; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Serum response factor (SRF) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class6.1: Rel homology region factors |
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EBF1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [6] | ||||
TF Protein Name |
Transcription factor COE1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor COE1 (EBF1) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class6.3: p53 domain factors |
Click to Show/Hide the Full List of 1 TF(s) Regulating This DT |
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TP53 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene in HFKS condition | [20] | ||||
TF Protein Name |
Cellular tumor antigen p53 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC16A3 gene in HFKS condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
Transcriptional Phenomenon2 |
Binding to SLC16A3 gene in health condition | [21] | ||||
TF Protein Name |
Cellular tumor antigen p53 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC16A3 gene in health condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
Class6.4: Runt domain factors |
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RUNX1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC16A3 gene in megakaryocytes condition | [17] | ||||
TF Protein Name |
Runt-related transcription factor 1 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC16A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 4. | |||||
RUNX2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Runt-related transcription factor 2 | Transcription Factor Info | ||||
Tissue |
Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Runt-related transcription factor 2 (RUNX2) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class6.7: Grainyhead domain factors |
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GRHL2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Grainyhead-like protein 2 homolog | Transcription Factor Info | ||||
Tissue |
Breast; Bronchus; Ovary | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
GRHL3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [4] | ||||
TF Protein Name |
Grainyhead-like protein 3 homolog | Transcription Factor Info | ||||
Tissue |
Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold |
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Class7.1: SMAD/NF-1 DNA-binding domain factors |
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NFIC |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [5] | ||||
TF Protein Name |
Nuclear factor 1 C-type | Transcription Factor Info | ||||
Tissue |
Brain; Liver; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Nuclear factor 1 C-type (NFIC) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class8.1: TATA-binding proteins |
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TBP |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
TATA-box-binding protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Embryo; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
TATA-box-binding protein (TBP) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
Class10.1: Other factors |
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GTF2B |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC16A3 gene | [2] | ||||
TF Protein Name |
Transcription initiation factor IIB | Transcription Factor Info | ||||
Tissue |
Cervix; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription initiation factor IIB (GTF2B) can directly bind to the SLC16A3 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 4. | |||||
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