Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0107 Transporter Info
Gene Name SLC16A3
Transporter Name Monocarboxylate transporter 4
Gene ID
9123
UniProt ID
O15427
Microbiota Influence of This DT (MBI)

Bacteria: Bacteroidota

   Genus: Prevotella

     Prevotella copri 

Microbe Info

Click to Show/Hide the Full List 6 Microbe Influence Related to This Species      

       Microbe Influence1

 Up regulating of SLC16A3 expression in starvation condition [1], [2], [3]

Regulating Factor
Short-chain fatty acid (Acetate)

Studied Phenotype

 Starvation [ICD11: 5B7Z]

Studied Tissue

 Heart

In Vivo Model

 129S1/SvImJ mice

Detailed Description

 The metabolite short-chain fatty acid (acetate) generated from the metabolism of dietary food by the Prevotella copri has been reported to increase the expression of the drug transporter SLC16A3.

       Microbe Influence2

 Up regulating of SLC16A3 expression in starvation condition [1], [2], [3]

Regulating Factor
Short-chain fatty acid (Acetate)

Studied Phenotype

 Starvation [ICD11: 5B7Z]

Studied Tissue

 Small intestine

In Vivo Model

 129S1/SvImJ mice

Detailed Description

 The metabolite short-chain fatty acid (acetate) generated from the metabolism of dietary food by the Prevotella copri has been reported to increase the expression of the drug transporter SLC16A3.

       Microbe Influence3

 Up regulating of SLC16A3 expression in starvation condition [1], [2], [3]

Regulating Factor
Short-chain fatty acid (Butyrate)

Studied Phenotype

 Starvation [ICD11: 5B7Z]

Studied Tissue

 Heart

In Vivo Model

 129S1/SvImJ mice

Detailed Description

 The metabolite short-chain fatty acid (butyrate) generated from the metabolism of dietary food by the Prevotella copri has been reported to increase the expression of the drug transporter SLC16A3.

       Microbe Influence4

 Up regulating of SLC16A3 expression in starvation condition [1], [2], [3]

Regulating Factor
Short-chain fatty acid (Butyrate)

Studied Phenotype

 Starvation [ICD11: 5B7Z]

Studied Tissue

 Small intestine

In Vivo Model

 129S1/SvImJ mice

Detailed Description

 The metabolite short-chain fatty acid (butyrate) generated from the metabolism of dietary food by the Prevotella copri has been reported to increase the expression of the drug transporter SLC16A3.

       Microbe Influence5

 Up regulating of SLC16A3 expression in starvation condition [1], [2], [3]

Regulating Factor
Short-chain fatty acid (Propionate)

Studied Phenotype

 Starvation [ICD11: 5B7Z]

Studied Tissue

 Heart

In Vivo Model

 129S1/SvImJ mice

Detailed Description

 The metabolite short-chain fatty acid (propionate) generated from the metabolism of dietary food by the Prevotella copri has been reported to increase the expression of the drug transporter SLC16A3.

       Microbe Influence6

 Up regulating of SLC16A3 expression in starvation condition [1], [2], [3]

Regulating Factor
Short-chain fatty acid (Propionate)

Studied Phenotype

 Starvation [ICD11: 5B7Z]

Studied Tissue

 Small intestine

In Vivo Model

 129S1/SvImJ mice

Detailed Description

 The metabolite short-chain fatty acid (propionate) generated from the metabolism of dietary food by the Prevotella copri has been reported to increase the expression of the drug transporter SLC16A3.
References
1 Tissue-specific expression of monocarboxylate transporters during fasting in mice. PLoS One. 2014 Nov 12;9(11):e112118.
2 The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020 Jan 31;11:25.
3 The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol. 2019 Aug;16(8):461-478.

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