| General Information of DT | |||||
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| DT ID | DTD0097 | ||||
| Gene Name | SLC14A2 | ||||
| Protein Name | Urea transporter 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:4EZC_A Identity:65.084% Minimized Score:-1024.405 kcal/mol Detail: Structure Info |
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| Synonyms | HUT2; SLC14A2; Solute carrier family 14 member 2; UT-A2; UT2; UTA; UTR; Urea transporter, kidney; hUT-A6 | ||||
| DT Family | Urea Transporter (UT) Family ; | ||||
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in theinner medulla of the kidney. | ||||
| Function | This transporter mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. | ||||
| Endogenous Substrate(s) | Urea | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Urea transporter 2 |
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(β) Cell Distribution Level of Urea transporter 2 |
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(γ) Organelle Distribution Level of Urea transporter 2 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Urea transporter 2 |
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(γ) Transcriptional Regulation of Urea transporter 2 |
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(δ) Epigenetic Regulation of Urea transporter 2 |
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(ε) Exogenous Modulation of Urea transporter 2 |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Urea transporter 2 |
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(β) Disease-specific Protein Abundances of Urea transporter 2 |
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(γ) Species- and Tissue-specific DT Abundances |
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