General Information of Drug Transporter (DT)
DT ID	DTD0097 Transporter Info
Gene Name	SLC14A2
Transporter Name	Urea transporter 2
Gene ID	8170
UniProt ID	Q15849
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	4EZC_A		Identity	65.084%
Performance	Minimized Score	-1024.405 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	High
Ramachandran Plot
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	Ramz Z Score	-0.45 ±0.41
	Residues in Favored Region	347	Ramachandran favored	97.75%
	Number of Outliers	1	Ramachandran outliers	0.28%
Local Quality
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	QMEANBrane Score		0.85
AlphaFold Protein Structure Database	Q15849 Click to jump to the details page
SWISS-MODEL Database	Q15849 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8BLO	EM	2.9 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A/B/C
Sequence Length	910		Mutation	No
8XD7	EM	2.6 Å	Spodoptera aff. frugiperda 1 BOLD-2017	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	397		Mutation	No
8XD9	EM	2.8 Å	Spodoptera frugiperda	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	397		Mutation	No
8XDA	EM	3 Å	Spodoptera frugiperda	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	397		Mutation	No
8XDB	EM	3.3 Å	Spodoptera	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	397		Mutation	No
8XDC	EM	3 Å	Spodoptera frugiperda	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	397		Mutation	No
8XDD	EM	3 Å	Spodoptera	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	397		Mutation	No
8XDE	EM	2.3 Å	Spodoptera frugiperda	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	451		Mutation	No
References
1	Structural characterization of human urea transporters UT-A and UT-B and their inhibition. Sci Adv. 2023;9(39):eadg8229.
2	Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters. Nat Commun. 2024;15(1):10226.

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