Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0097 Transporter Info
Gene Name SLC14A2
Transporter Name Urea transporter 2
Gene ID
8170
UniProt ID
Q15849

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

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       Transcriptional Phenomenon1

 Direct binding to SLC14A2 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC14A2 gene, which in turn affects the expression or function of the drug transporter Urea transporter 2.

      Class1.3: Basic helix-span-helix factors

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        TFAP2A 

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       Transcriptional Phenomenon1

 Binding to SLC14A2 gene in health condition [2]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC14A2 gene in health condition, which leads to an affected expression of the drug transporter Urea transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC14A2 gene [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC14A2 gene in . condition, which leads to a affected expression of the drug transporter Urea transporter 2.

        PPARD 

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       Transcriptional Phenomenon1

 Repression of SLC14A2 gene in myofibroblasts condition [4]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC14A2 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Urea transporter 2.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Binding to SLC14A2 gene in megakaryocytes condition [5]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC14A2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Urea transporter 2.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC14A2 gene in erythroleukemia condition [6]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC14A2 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Urea transporter 2.

        KLF12 

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       Transcriptional Phenomenon1

 Activation of SLC14A2 gene in health condition [7]

TF Protein Name

 Krueppel-like factor 12 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Krueppel-like factor 12 (KLF12) has been reported to activate the transcription of SLC14A2 gene in health condition, which leads to an increased expression of the drug transporter Urea transporter 2.

        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC14A2 gene [8]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC14A2 gene, which in turn affects the expression or function of the drug transporter Urea transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F1 

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       Transcriptional Phenomenon1

 Binding to SLC14A2 gene in MCF7 cells [2]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC14A2 gene in MCF7 cells, which leads to an affected expression of the drug transporter Urea transporter 2.

        FOXA1 

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       Transcriptional Phenomenon1

 Binding to SLC14A2 gene in prostate carcinoma condition [9]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC14A2 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Urea transporter 2.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC14A2 gene in epithelial to mesenchymal transition condition [10]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC14A2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Urea transporter 2.

      Class6.4: Runt domain factors

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        RUNX2 

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       Transcriptional Phenomenon1

 Activation of SLC14A2 gene in prostate cancer condition [11]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC14A2 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Urea transporter 2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD3 

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       Transcriptional Phenomenon1

 Activation of SLC14A2 gene in hESCs condition [12]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC14A2 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Urea transporter 2.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC14A2 gene in human embryonic stem cells (hESCs) condition [12]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC14A2 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Urea transporter 2.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-266. (ID:ENSG00000132874)
2 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
3 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
4 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
5 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
6 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
7 Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Biochem Biophys Res Commun. 2006 May 26;344(1):246-52.
8 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
9 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
10 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
11 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
12 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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