Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0097 Transporter Info
Gene Name SLC14A2
Transporter Name Urea transporter 2
Gene ID
8170
UniProt ID
Q15849
Epigenetic Regulations of This DT (EGR)

Methylation

  Atypical teratoid rhabdoid tumor

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in atypical teratoid rhabdoid tumor [ 1 ]

Location

 5'UTR (cg18047353)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:2.44E-06; Z-score:-1.05E+00

Methylation in Case

 8.65E-01 (Median) Methylation in Control 9.15E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in atypical teratoid rhabdoid tumor [ 1 ]

Location

 3'UTR (cg15090262)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.40E+00 Statistic Test p-value:5.80E-11; Z-score:-1.36E+00

Methylation in Case

 2.91E-01 (Median) Methylation in Control 4.06E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Breast cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in breast cancer [ 2 ]

Location

 5'UTR (cg18047353)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-2.01E+00 Statistic Test p-value:1.47E-23; Z-score:-3.28E+00

Methylation in Case

 2.14E-01 (Median) Methylation in Control 4.29E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in breast cancer [ 2 ]

Location

 TSS1500 (cg21186506)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:9.41E-04; Z-score:-7.96E-01

Methylation in Case

 8.73E-01 (Median) Methylation in Control 9.03E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC14A2 in breast cancer [ 2 ]

Location

 Body (cg15536830)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.55E+00 Statistic Test p-value:2.80E-12; Z-score:-1.73E+00

Methylation in Case

 6.29E-02 (Median) Methylation in Control 9.75E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC14A2 in breast cancer [ 2 ]

Location

 3'UTR (cg15090262)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.09E+00 Statistic Test p-value:3.92E-02; Z-score:-9.61E-01

Methylation in Case

 6.92E-01 (Median) Methylation in Control 7.54E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Hepatocellular carcinoma

            7 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in hepatocellular carcinoma [ 3 ]

Location

 5'UTR (cg18047353)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.23E+00 Statistic Test p-value:1.43E-03; Z-score:-8.01E-01

Methylation in Case

 1.43E-01 (Median) Methylation in Control 1.77E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in hepatocellular carcinoma [ 3 ]

Location

 TSS1500 (cg14931811)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.24E+00 Statistic Test p-value:4.44E-06; Z-score:-1.01E+00

Methylation in Case

 4.43E-01 (Median) Methylation in Control 5.47E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC14A2 in hepatocellular carcinoma [ 3 ]

Location

 TSS1500 (cg22064129)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:3.00E-05; Z-score:-1.66E+00

Methylation in Case

 8.24E-01 (Median) Methylation in Control 8.53E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC14A2 in hepatocellular carcinoma [ 3 ]

Location

 TSS1500 (cg21186506)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.04E+00 Statistic Test p-value:5.65E-05; Z-score:-1.04E+00

Methylation in Case

 8.38E-01 (Median) Methylation in Control 8.74E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of SLC14A2 in hepatocellular carcinoma [ 3 ]

Location

 Body (cg01348442)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.47E+00 Statistic Test p-value:1.08E-14; Z-score:-5.42E+00

Methylation in Case

 4.88E-01 (Median) Methylation in Control 7.16E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of SLC14A2 in hepatocellular carcinoma [ 3 ]

Location

 Body (cg06347454)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.31E+00 Statistic Test p-value:1.15E-09; Z-score:-2.70E+00

Methylation in Case

 5.92E-01 (Median) Methylation in Control 7.73E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of SLC14A2 in hepatocellular carcinoma [ 3 ]

Location

 Body (cg15536830)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.29E+00 Statistic Test p-value:1.97E-09; Z-score:-1.28E+00

Methylation in Case

 7.50E-02 (Median) Methylation in Control 9.68E-02 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Pancretic ductal adenocarcinoma

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in pancretic ductal adenocarcinoma [ 4 ]

Location

 5'UTR (cg12793733)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.13E+00 Statistic Test p-value:1.75E-02; Z-score:7.94E-01

Methylation in Case

 5.86E-01 (Median) Methylation in Control 5.17E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in pancretic ductal adenocarcinoma [ 4 ]

Location

 Body (cg16118678)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:5.35E-05; Z-score:-5.92E-01

Methylation in Case

 7.99E-01 (Median) Methylation in Control 8.21E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in papillary thyroid cancer [ 5 ]

Location

 5'UTR (cg18047353)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.37E+00 Statistic Test p-value:2.92E-11; Z-score:-2.15E+00

Methylation in Case

 2.73E-01 (Median) Methylation in Control 3.75E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in papillary thyroid cancer [ 5 ]

Location

 TSS1500 (cg21186506)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:2.40E-02; Z-score:-5.08E-01

Methylation in Case

 9.24E-01 (Median) Methylation in Control 9.29E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC14A2 in papillary thyroid cancer [ 5 ]

Location

 Body (cg15536830)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.08E+00 Statistic Test p-value:1.15E-02; Z-score:-5.48E-01

Methylation in Case

 7.37E-02 (Median) Methylation in Control 7.96E-02 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Systemic lupus erythematosus

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in systemic lupus erythematosus [ 6 ]

Location

 5'UTR (cg18047353)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:1.84E-02; Z-score:-3.29E-01

Methylation in Case

 3.13E-01 (Median) Methylation in Control 3.33E-01 (Median)

Studied Phenotype

 Systemic lupus erythematosus[ ICD-11:4A40.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in systemic lupus erythematosus [ 6 ]

Location

 TSS1500 (cg22064129)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:4.11E-03; Z-score:-2.01E-01

Methylation in Case

 7.90E-01 (Median) Methylation in Control 7.98E-01 (Median)

Studied Phenotype

 Systemic lupus erythematosus[ ICD-11:4A40.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC14A2 in systemic lupus erythematosus [ 6 ]

Location

 TSS1500 (cg14931811)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:4.10E-02; Z-score:-8.49E-02

Methylation in Case

 8.62E-01 (Median) Methylation in Control 8.68E-01 (Median)

Studied Phenotype

 Systemic lupus erythematosus[ ICD-11:4A40.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC14A2 in systemic lupus erythematosus [ 6 ]

Location

 Body (cg15536830)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.12E+00 Statistic Test p-value:2.79E-02; Z-score:-3.91E-01

Methylation in Case

 1.12E-01 (Median) Methylation in Control 1.26E-01 (Median)

Studied Phenotype

 Systemic lupus erythematosus[ ICD-11:4A40.0]

Experimental Material

 Patient tissue samples

  Bladder cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in bladder cancer [ 7 ]

Location

 TSS1500 (cg21186506)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.02E+00 Statistic Test p-value:1.02E-02; Z-score:-1.59E+00

Methylation in Case

 8.91E-01 (Median) Methylation in Control 9.05E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in bladder cancer [ 7 ]

Location

 TSS1500 (cg22064129)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.02E+00 Statistic Test p-value:1.78E-02; Z-score:-7.02E-01

Methylation in Case

 6.94E-01 (Median) Methylation in Control 7.05E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC14A2 in bladder cancer [ 7 ]

Location

 Body (cg15536830)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.51E+00 Statistic Test p-value:8.10E-05; Z-score:-3.89E+00

Methylation in Case

 5.41E-02 (Median) Methylation in Control 8.14E-02 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of SLC14A2 in bladder cancer [ 7 ]

Location

 3'UTR (cg15090262)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.15E+00 Statistic Test p-value:5.32E-06; Z-score:-7.10E+00

Methylation in Case

 6.85E-01 (Median) Methylation in Control 7.90E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Colorectal cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in colorectal cancer [ 8 ]

Location

 TSS1500 (cg22064129)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:1.32E-05; Z-score:-1.24E+00

Methylation in Case

 9.25E-01 (Median) Methylation in Control 9.37E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in colorectal cancer [ 8 ]

Location

 Body (cg15536830)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.13E+00 Statistic Test p-value:6.78E-03; Z-score:-3.67E-01

Methylation in Case

 1.19E-01 (Median) Methylation in Control 1.34E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of SLC14A2 in colorectal cancer [ 8 ]

Location

 3'UTR (cg15090262)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.11E+00 Statistic Test p-value:3.51E-09; Z-score:-4.93E+00

Methylation in Case

 7.86E-01 (Median) Methylation in Control 8.73E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  HIV infection

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in HIV infection [ 9 ]

Location

 TSS1500 (cg14931811)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.05E+00 Statistic Test p-value:3.78E-03; Z-score:-1.46E+00

Methylation in Case

 8.47E-01 (Median) Methylation in Control 8.90E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Prostate cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in prostate cancer [ 10 ]

Location

 TSS1500 (cg16377872)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.32E+00 Statistic Test p-value:1.53E-02; Z-score:-9.24E+00

Methylation in Case

 6.87E-01 (Median) Methylation in Control 9.07E-01 (Median)

Studied Phenotype

 Prostate cancer[ ICD-11:2C82]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in prostate cancer [ 10 ]

Location

 Body (cg18576686)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:2.63E-03; Z-score:3.28E+00

Methylation in Case

 9.05E-01 (Median) Methylation in Control 8.65E-01 (Median)

Studied Phenotype

 Prostate cancer[ ICD-11:2C82]

Experimental Material

 Patient tissue samples

  Lung adenocarcinoma

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of SLC14A2 in lung adenocarcinoma [ 11 ]

Location

 Body (cg15536830)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.15E+00 Statistic Test p-value:4.84E-02; Z-score:-7.78E-01

Methylation in Case

 1.14E-01 (Median) Methylation in Control 1.32E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of SLC14A2 in lung adenocarcinoma [ 11 ]

Location

 3'UTR (cg15090262)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.05E+00 Statistic Test p-value:1.18E-02; Z-score:-1.60E+00

Methylation in Case

 7.57E-01 (Median) Methylation in Control 7.92E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples
References
1 Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. 2016 Mar 14;29(3):379-393.
2 Genome-wide Scan for Methylation Profiles in Breast Cancer
3 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
4 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
5 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
6 Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet. 2013;9(8):e1003678.
7 DNA Methylation Dynamics in Urological Tumors.
8 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
9 HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015 Nov 15;212(10):1563-73.
10 Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.
11 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues

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