Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0097 Transporter Info | ||||
| Gene Name | SLC14A2 | ||||
| Protein Name | Urea transporter 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs1123617 | ||||
| Site of GPD | chr18:45672918 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | G>A / G>T | ||||
| Minor Allele Frequency | A=0.1703/853 (Global) | ||||
| Genotype AA | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Nifedipine | Drug Info | Hypertension | Correlated with the larger mean changes in systolic and diastolic blood pressure in patients (compare with genotype GG) | [ 1] | |
| Nifedipine | N.A. | Cardiotoxicity | Genotype AA is associated with larger mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Nifedipine | N.A. | Hypertension | Genotype AA is associated with larger mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Genotype GA | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Nifedipine | Drug Info | Hypertension | Correlated with the larger mean changes in systolic and diastolic blood pressure in patients (compare with genotype GG) | [ 1] | |
| Genotype AG | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Nifedipine | N.A. | Cardiotoxicity | Genotype AG is associated with larger mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Nifedipine | N.A. | Hypertension | Genotype AG is associated with larger mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Genotype GG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Nifedipine | N.A. | Hypertension | Patients with the GG genotype who are treated with nifediping may have smaller changes in systolic and diastolic blood pressure as compared to patients with the GA and AA genotype. Other genetic and clinical factors may also influence a patient's response to nifedipine. | [ 1] | |
| Genetic Polymorphism | rs3745009 | ||||
| Site of GPD | chr18:45682394 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | G>A | ||||
| Minor Allele Frequency | A=0.4277/2142 (Global) | ||||
| Genotype AA | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Nifedipine | Drug Info | Hypertension | Correlated with the smaller mean changes in systolic and diastolic blood pressure in patients (compare with genotype GG) | [ 1] | |
| Nifedipine | N.A. | Cardiotoxicity | Genotype AA is associated with smaller mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Nifedipine | N.A. | Hypertension | Genotype AA is associated with smaller mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Genotype GA | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Nifedipine | Drug Info | Hypertension | Correlated with the Smaller mean changes in systolic and diastolic blood pressure in patients (compare with genotype GG) | [ 1] | |
| Genotype AG | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Nifedipine | N.A. | Cardiotoxicity | Genotype AG is associated with smaller mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Nifedipine | N.A. | Hypertension | Genotype AG is associated with smaller mean changes in systolic and diastolic blood pressure when treated with nifedipine as compared to genotype GG. | [ 1] | |
| Genotype GG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Nifedipine | N.A. | Hypertension | Patients with the GG genotype who are treated with nifedipine may have larger mean changes in systolic and diastolic blood pressure as compared to patients with the GA and AA genotype. Other genetic and clinical factors may also influence a patient's response to nifedipine treatment. | [ 1] | |
| Genetic Polymorphism | rs12456693 | ||||
| Site of GPD | chr18:45334299 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>T | ||||
| Minor Allele Frequency | C=0.8140/1610 (Global) | ||||
| Allele T | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Clopidogrel | N.A. | Cardiotoxicity | Allele T is associated with increased response to clopidogrel in people with Coronary Artery Disease as compared to allele C. | [ 2] | |
| Genotype CT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Clopidogrel | N.A. | Cardiotoxicity | Genotype CT is associated with increased metabolism of clopidogrel as compared to genotype CC. | [ 3] | |
| Genotypes CT + TT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Clopidogrel | N.A. | Major Adverse Cardiac Events (mace) | Genotypes CT + TT are associated with decreased likelihood of major adverse cardiac events (mace) when treated with clopidogrel in people with Coronary Artery Disease as compared to genotype CC. | [ 2] | |
| References | |||||
| 1 | Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS. Methods Find Exp Clin Pharmacol. 2007 Jan-Feb;29(1):3-10. | ||||
| 2 | Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients. Acta Pharmacol Sin. 2019 Jun;40(6):762-768. | ||||
| 3 | Genomewide Association Study Identifies Novel Genetic Loci That Modify Antiplatelet Effects and Pharmacokinetics of Clopidogrel. Clin Pharmacol Ther. 2017 Jun;101(6):791-802. | ||||
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