Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00396
|
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| Drug Name |
Nifedipine
|
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| Synonyms |
AWD Pharma Brand of Nifedipine; Adalat; Adalat (TN); Adalat 10; Adalat 20; Adalat 5; Adalat CC; Adalat CR; Adalat Crono; Adalat FT; Adalat GITS; Adalat GITS 30; Adalat LA; Adalat LP; Adalat Oros; Adalat PA; Adalat Retard; Adalat XL; Adalate; Adalate LP; Adapine; Adapress; Adcock Ingram Brand of Nifedipine; Adipine XL; Afeditab; Afeditab CR; Afeditab CR (TN); Alat; Aldipin; Alfadal; Alonix; Alonix S; Alpha-Nifedipine Retard;Apo-Nifed; Angipec; Anifed; Anpine; Aprical; Aprical long; Bay-1040; Bay-a-1040; Bay1040; Bayer Brand of Nifedipine; Bonacid; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardionorm; Chronadalate; Chronadalate LP; Citilat; Coracten; Coracten XL; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Cordipine; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dipinkor; Duranifin; Ecodipi; Ecodipin; Ecodipin E; Emaberin; Fedcor; Fedcor Retard; Fenamon; Fenamon SR; Fenigidin; Fenihidin; Fenihidine; Fortipine LA; Glopir; Hadipin; Hexadilat; Infedipin; Introcar; KB-1712P; KRKA Brand of Nifedipine; Kordafen; Korinfar; Macorel; Megalat; Monohydrochloride, Nifedipine; Myogard; N 7634; N1fedilat; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifediac; Nifedical; Nifedical (TN); Nifedical XL; Nifedicor; Nifedin; Nifedine; Nifedipine (JP15/USP/INN); Nifedipine Bayer Brand; Nifedipine GTIS; Nifedipine KRKA Brand; Nifedipine Monohydrochloride; Nifedipine Orion Brand; Nifedipine Pfizer Brand; Nifedipine Retard; Nifedipine [USAN:BAN:INN:JAN]; Nifedipine-GTIS; Nifedipino; Nifedipino [INN-Spanish]; Nifedipinum; Nifedipinum [INN-Latin]; Nifedipres; Nifedirex LP; Nifelan; Nifelat; Nifelat Q; Nifelate; Nifensar XL; Nificard; Nifidine; Nifipen; Niphedipine; Orion Brand of Nifedipine; Orix; Oxcord; Pfizer Brand of Nifedipine; Pidilat; Procardia; Procardia (TN); Procardia XL; Sepamit; Slofedipine XL; Tensipine MR; Tibricol; Vascard; Zenusin
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| Drug Type |
Small molecular drug
|
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| Indication | Angina [ICD11:BA40] | Approved | [1] | |||
| Therapeutic Class |
Analgesics
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C17H18N2O6
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| Canonical SMILES |
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
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| InChI |
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
|
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| InChIKey |
HYIMSNHJOBLJNT-UHFFFAOYSA-N
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| CAS Number |
CAS 21829-25-4
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| Pharmaceutical Properties | Molecular Weight | 346.3 | Topological Polar Surface Area | 110 | ||
| Heavy Atom Count | 25 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 7 | |||
| XLogP |
2.2
|
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| PubChem CID | ||||||
| PubChem SID |
10321407
,10513802
,11111548
,11111549
,11113899
,11119993
,11120481
,11120969
,11121456
,11121936
,11147076
,11335488
,11360727
,11362525
,11363873
,11364812
,11365087
,11366435
,11367374
,11367649
,11368997
,11369936
,11370321
,11370322
,11371671
,11372976
,11373250
,11373766
,11375536
,11375811
,11377159
,11378103
,11461699
,11466091
,11467211
,11484752
,11485902
,11488874
,3153213
,5010834
,6300547
,634276
,7847503
,7980124
,8145946
,8149443
,8152762
,841058
,855613
,9475
|
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| ChEBI ID |
ChEBI:7565
|
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | P-GP | Transporter Info | P-glycoprotein 1 | Substrate | [2] | |
| References | ||||||
| 1 | Nifedipine was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. | |||||
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