| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0096 | ||||
| Gene Name | SLC14A1 | ||||
| Protein Name | Urea transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6QD5_A Identity:99.157% Minimized Score:-1063.343 kcal/mol Detail: Structure Info |
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| Synonyms | HUT11; HsT1341; JK; RACH1; RACH2; SLC14A1; Solute carrier family 14 member 1; UT-B1; UT1; UTE; Urea transporter, erythrocyte; hUT1; UT1b | ||||
| DT Family | Urea Transporter (UT) Family ; | ||||
| Tissue Specificity | Detected in erythrocytes (at protein level).Erythrocytes. | ||||
| Function | This urea transporter facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. | ||||
| Endogenous Substrate(s) | Urea | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Urea transporter 1 |
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(β) Cell Distribution Level of Urea transporter 1 |
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(γ) Organelle Distribution Level of Urea transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Urea transporter 1 |
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(γ) Transcriptional Regulation of Urea transporter 1 |
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(δ) Epigenetic Regulation of Urea transporter 1 |
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(ε) Exogenous Modulation of Urea transporter 1 |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Urea transporter 1 |
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(β) Disease-specific Protein Abundances of Urea transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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