General Information of Drug Transporter (DT)
DT ID	DTD0096 Transporter Info
Gene Name	SLC14A1
Transporter Name	Urea transporter 1
Gene ID	6563
UniProt ID	Q13336
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6QD5_A		Identity	99.157%
Performance	Minimized Score	-1063.343 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	High
Ramachandran Plot
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	Ramz Z Score	-1.29 ±0.38
	Residues in Favored Region	345	Ramachandran favored	97.46%
	Number of Outliers	1	Ramachandran outliers	0.28%
Local Quality
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	QMEANBrane Score		0.87
AlphaFold Protein Structure Database	Q13336 Click to jump to the details page
SWISS-MODEL Database	Q13336 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
6QD5	X-ray	2.4 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	31-389		Mutation	Yes
8BLP	EM	2.6 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	367		Mutation	No
8XDF	EM	2.4 Å	Spodoptera frugiperda	Click to Show/Hide the Details	[3]
Structure
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Corresponding chain	A/B/C
Sequence Length	389		Mutation	No
References
1	RCSB PDB: X-ray Structure of the Human Urea Channel SLC14A1/UT1.
2	Structural characterization of human urea transporters UT-A and UT-B and their inhibition. Sci Adv. 2023;9(39):eadg8229.
3	Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters. Nat Commun. 2024;15(1):10226.

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