Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0096 Transporter Info
Gene Name SLC14A1
Transporter Name Urea transporter 1
Gene ID
6563
UniProt ID
Q13336

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPA 

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       Transcriptional Phenomenon1

 Direct binding to SLC14A1 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC14A1 gene, which in turn affects the expression or function of the drug transporter Urea transporter 1.

      Class1.2: Basic helix-loop-helix factors

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        MYC 

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       Transcriptional Phenomenon1

 Binding to SLC14A1 gene in embryonic stem cells condition [2]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC14A1 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Urea transporter 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

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       Transcriptional Phenomenon1

 Binding to SLC14A1 gene [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC14A1 gene in . condition, which leads to a affected expression of the drug transporter Urea transporter 1.

        RXRG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC14A1 gene [4]

TF Protein Name

 Retinoic acid receptor RXR-gamma Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC14A1 gene, which in turn affects the expression or function of the drug transporter Urea transporter 1.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC14A1 gene in THP-1 human monocytic leukemia cells condition [5]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Affected Drug/Substrate

 1,25-dihydroxyvitamin D3

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC14A1 gene in THP-1 human monocytic leukemia cells condition, which leads to an increased expression of the drug transporter Urea transporter 1.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Binding to SLC14A1 gene in hematopoiesis condition [6]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC14A1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Urea transporter 1.

       Transcriptional Phenomenon2

 Binding to SLC14A1 gene in megakaryocytes condition [7]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC14A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Urea transporter 1.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC14A1 gene in hematopoiesis condition [6]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC14A1 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Urea transporter 1.

      Class2.3: C2H2 zinc finger factors

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        CTCF 

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       Transcriptional Phenomenon1

 Direct binding to SLC14A1 gene [1]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC14A1 gene, which in turn affects the expression or function of the drug transporter Urea transporter 1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC14A1 gene [8]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC14A1 gene, which in turn affects the expression or function of the drug transporter Urea transporter 1.

TF Superclass3: Helix-turn-helix domains

      Class3.5: Tryptophan cluster factors

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        ERG 

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       Transcriptional Phenomenon1

 Direct binding to SLC14A1 gene [8]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC14A1 gene, which in turn affects the expression or function of the drug transporter Urea transporter 1.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC14A1 gene [4]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Stomach; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC14A1 gene, which in turn affects the expression or function of the drug transporter Urea transporter 1.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC14A1 gene [9]

TF Protein Name

 Transcription factor COE1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor COE1 (EBF1) can directly bind to the SLC14A1 gene, which in turn affects the expression or function of the drug transporter Urea transporter 1.

        NFAT5 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC14A1 gene in hypokalemia condition [10]

TF Protein Name

 Nuclear factor of activated T-cells 5 Transcription Factor Info

Studied Phenotype

 Hypokalemia [ICD11: 5C77]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 Sprague-Dawley rats

Detailed Description

 Nuclear factor of activated T-cells 5 (NFAT5) has been reported to activate the transcription of SLC14A1 gene in hypokalemia condition, which leads to an increased expression of the drug transporter Urea transporter 1.

       Transcriptional Phenomenon2

 Activation of SLC14A1 gene in health condition [11]

TF Protein Name

 Nuclear factor of activated T-cells 5 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Nuclear factor of activated T-cells 5 (NFAT5) has been reported to activate the transcription of SLC14A1 gene in health condition, which leads to an increased expression of the drug transporter Urea transporter 1.

        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC14A1 gene in immortal lymphoblast cell lines condition [12]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC14A1 gene in immortal lymphoblast cell lines condition, which leads to an affected expression of the drug transporter Urea transporter 1.

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to SLC14A1 gene in health condition [13]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC14A1 gene in health condition, which leads to an affected expression of the drug transporter Urea transporter 1.

      Class6.4: Runt domain factors

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        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC14A1 gene in prostate cancer condition [14]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC14A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Urea transporter 1.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-299. (ID:ENSG00000141469)
2 Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
3 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
6 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
7 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
8 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
9 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
10 Downregulation of renal TonEBP in hypokalemic rats. Am J Physiol Renal Physiol. 2007 Jul;293(1):F408-15.
11 Sequential expression of NKCC2, TonEBP, aldose reductase, and urea transporter-A in developing mouse kidney. Am J Physiol Renal Physiol. 2007 Jan;292(1):F269-77.
12 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
13 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
14 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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