General Information of Drug Transporter (DT)
DT ID DTD0096 Transporter Info
Gene Name SLC14A1
Protein Name Urea transporter 1
Gene ID
6563
UniProt ID
Q13336
3D Structure

Modelled Stucture

Method:Homology modeling

Teplate PDB:6QD5_A

Identity:99.157%

Minimized Score:-1063.343

Detail: Structure Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Slc14a1
        UniProt ID
Q8VHL0
        UniProt Entry
UT1_MOUSE
        3D Structure

Method:Homology modeling

Teplate PDB:4EZC_A

Sequence Length:384

Identity:85.417%

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        Performance Minimized Score -1043.254 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

High

        Ramachandran Plot

Ramz Z Score:-1 ±0.38

Residues in Favored Region:366

Ramachandran favored:95.81%

Number of Outliers:1

Ramachandran outliers:0.26%

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        Local Quality

QMEANBrane Score:0.83

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Rattus norvegicus (Rat)
        Gene Name Slc14a1
        UniProt ID
P97689
        UniProt Entry
UT1_RAT
        3D Structure

Method:Homology modeling

Teplate PDB:4EZC_A

Sequence Length:384

Identity:83.073%

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        Performance Minimized Score -1073.767 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

High

        Ramachandran Plot

Ramz Z Score:-1.29 ±0.36

Residues in Favored Region:374

Ramachandran favored:97.91%

Number of Outliers:0

Ramachandran outliers:0.00%

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        Local Quality

QMEANBrane Score:0.83

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Bos taurus (Bovine)
        Gene Name SLC14A1
        UniProt ID
Q5QF96
        UniProt Entry
UT1_BOVIN
        3D Structure

Crystallisation Method:X-ray

Expression System:Spodoptera frugiperda

PDB ID:4EZC

Corresponding Chain:A/B/C

Sequence Length:1-384

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        Experimental Structures of This Model Oganism
                PDB ID Scanning Method Resolution Expression System Details Ref
                4EZD X-ray 2.5 Å Spodoptera frugiperda
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[ 1]
Structure
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Corresponding chain A/B/C
Sequence Length 1-384 Mutation No
References
1 Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11194-9.

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