Drug Transporter (DT) Information

General Information of DT
DT ID DTD0052
Gene Name ABCB6
Protein Name ATP-binding cassette sub-family B member 6
Gene ID
10058
UniProt ID
Q9NP58
TCDB ID
3.A.1.210.6
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:7D7R_A

Identity:98.807%

Minimized Score:-1551.742 kcal/mol

Detail: Structure Info

Synonyms ABCB6; LAN; MTABC3; Mitochondrial ABC transporter 3; Mt-ABC transporter 3; P-glycoprotein-related protein; PRP; UMAT; Ubiquitously-expressed mammalian ABC half transporter
DT Family ATP-Binding Cassette (ABC) Superfamily
Heavy Metal Transporter (HMT) Family (ABCB)
Tissue Specificity Widely expressed. High expression is detectedin the retinal epithelium.
Function This transporter plays a crucial role in heme synthesis. Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria.
Endogenous Substrate(s) Anionic porphyrins; Porphyrins
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-binding cassette sub-family B member 6
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-binding cassette sub-family B member 6
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-binding cassette sub-family B member 6
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of ATP-binding cassette sub-family B member 6
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-binding cassette sub-family B member 6
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-binding cassette sub-family B member 6
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-binding cassette sub-family B member 6
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-binding cassette sub-family B member 6
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-binding cassette sub-family B member 6
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Verteporfin
 Approved Drug Info Age-related macular degeneration 9B75.0 [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Porphyrin
66868
EM Info Unclear experiment used for identifying this EM [2]
References
1 Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies. J Biol Chem. 2013 Aug 2;288(31):22658-69.
2 The role of ABCG2 and ABCB6 in porphyrin metabolism and cell survival. Curr Pharm Biotechnol. 2011 Apr;12(4):647-55.

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