Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0052 Transporter Info
Gene Name	ABCB6
Transporter Name	ATP-binding cassette sub-family B member 6
Gene ID	10058
UniProt ID	Q9NP58

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	ABCB6 mRNA affects the susceptibility to Cisplatin		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cisplatin co-treated with jinfukang results in increased expression of ABCB6 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cisplatin results in increased expression of ABCB6 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ABCB6 protein results in decreased susceptibility to Fluorouracil		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cyclosporine results in increased expression of ABCB6 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of ABCB6 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased methylation of ABCB6 5' UTR		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of ABCB6 promoter		[38]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of ABCB6 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of ABCB6 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Amitrole	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ABCB6 inhibits the reaction Amitrole results in decreased activity of CAT protein which results in increased susceptibility to sodium arsenite		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Amitrole inhibits the reaction ABCB6 protein results in increased activity of CAT protein		[36]
Regulation Mechanism			Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in increased expression of ABCB6 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased expression of ABCB6 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of ABCB6 protein		[39]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased expression of ABCB6 protein		[39]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ABCB6 protein inhibits the reaction HMT-1 gene mutant form results in increased susceptibility to Cadmium Chloride		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ABCB6 protein results in decreased susceptibility to Cadmium Chloride		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCB6 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Cadmium Chloride results in increased expression of ABCB6 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
chloroacetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chloroacetaldehyde affects the expression of ABCB6 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
clothianidin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	clothianidin results in decreased expression of ABCB6 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Cobalt	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tungsten carbide co-treated with Cobalt results in increased expression of ABCB6 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of ABCB6 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	zinc chloride inhibits the reaction cobaltous chloride results in increased expression of ABCB6 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
deoxynivalenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	deoxynivalenol results in decreased expression of ABCB6 protein		[47]
Regulation Mechanism			Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Docetaxel results in decreased susceptibility to Docetaxel which results in increased expression of ABCB6 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol results in increased expression of ABCB6 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
glycidamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	glycidamide results in increased expression of ABCB6 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
Heme	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Heme results in increased expression of ABCB6 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Heme results in increased expression of ABCB6 protein		[51]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in decreased expression of ABCB6 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
Irinotecan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ABCB6 protein results in decreased susceptibility to Irinotecan		[50]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of ABCB6 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of ABCB6 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in increased expression of ABCB6 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of ABCB6 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in increased expression of ABCB6 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in increased expression of ABCB6 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB6 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in increased expression of ABCB6 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of ABCB6 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	7 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ABCB6 inhibits the reaction Amitrole results in decreased activity of CAT protein which results in increased susceptibility to sodium arsenite		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ABCB6 protein results in decreased susceptibility to sodium arsenite		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in decreased expression of ABCB6 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of ABCB6 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	sodium arsenite results in increased abundance of Arsenic which results in increased expression of ABCB6 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	sodium arsenite results in increased expression of ABCB6 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	sodium arsenite results in increased expression of ABCB6 protein		[36]
Regulation Mechanism			Transcription Factor Info
Sodium Dodecyl Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Dodecyl Sulfate results in decreased expression of ABCB6 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in increased expression of ABCB6 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of ABCB6 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in increased expression of ABCB6 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
tungsten carbide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tungsten carbide co-treated with Cobalt results in increased expression of ABCB6 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Vincristine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ABCB6 protein results in decreased susceptibility to Vincristine		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Vincristine results in decreased susceptibility to Vincristine which affects the expression of ABCB6 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zinc chloride inhibits the reaction cobaltous chloride results in increased expression of ABCB6 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ochratoxin A results in decreased expression of ABCB6 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ochratoxin A results in decreased expression of ABCB6 protein		[47]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Phenobarbital	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenobarbital affects the expression of ABCB6		[2]
Cisplatin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of ABCB6		[3]
Fluorouracil	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fluorouracil inhibits the expression of ABCB6		[3]
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the expression of ABCB6		[3]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of ABCB6		[4]
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cidofovir increases the expression of ABCB6		[5]
Ifosfamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ifosfamide increases the expression of ABCB6		[5]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of ABCB6		[6]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of ABCB6		[7]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of ABCB6		[8]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of ABCB6		[9]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of ABCB6		[10]
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cannabidiol inhibits the expression of ABCB6		[11]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ABCB6		[12]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ABCB6		[13]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of ABCB6		[5]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide inhibits the expression of ABCB6		[14]
Verteporfin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Verteporfin inhibits the activity of ABCB6		[15]
Drug in Phase 3 Trial
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulforafan increases the expression of ABCB6		[27]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of ABCB6		[26]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of ABCB6		[33]
Investigative Drug
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of ABCB6		[22]
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone increases the expression of ABCB6		[29]
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 inhibits the expression of ABCB6		[21]
Natural Product
Vitallium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitallium increases the expression of ABCB6		[20]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of ABCB6		[24]
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Jinfukang increases the expression of ABCB6		[23]
Environmental toxicant
Polycyclic aromatic hydrocarbons	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polycyclic aromatic hydrocarbons induces the activity of ABCB6		[1]
Cell System	Human liver-derived cell lines Huh7-ABCB6
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of ABCB6		[1]
Acute Toxic Substance
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A inhibits the expression of ABCB6		[17]
Acrylamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acrylamide inhibits the expression of ABCB6		[28]
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Antimycin A increases the expression of ABCB6		[30]
Paraquat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paraquat increases the expression of ABCB6		[31]
Carcinogen
Methylcholanthrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methylcholanthrene increases the expression of ABCB6		[1]
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of ABCB6		[19]
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of ABCB6		[32]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of ABCB6 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in increased expression of ABCB6 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCB6 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Pesticide/Insecticide
Clothianidin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clothianidin inhibits the expression of ABCB6		[25]
Health and Environmental Toxicant
Glycidamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycidamide increases the expression of ABCB6		[16]
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Atrazine inhibits the expression of ABCB6		[18]

References
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