Detail Information of Epigenetic Regulations

General Information of Drug Transporter (DT)
DT ID DTD0052 Transporter Info
Gene Name ABCB6
Transporter Name ATP-binding cassette sub-family B member 6
Gene ID
10058
UniProt ID
Q9NP58
Epigenetic Regulations of This DT (EGR)

Methylation

  Hepatocellular carcinoma

            9 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Hypermethylation of ABCB6 in hepatitis C virus-related hepatocellular carcinoma [ 1 ]

Epigenetic Type

 Methylation Experiment Method Methylation-specific PCR

Related Molecular Changes

 Down regulation ofABCB6 Experiment Method RT-qPCR

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples; Multiple cell lines of human

Additional Notes

 The percentage of DNA methylation of ABCB6 was inversely correlated with the ABCB6 mRNA levels in hepatoma cell lines and clinical samples.

  Epigenetic Phenomenon2

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 TSS1500 (cg13800769)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.55E+00 Statistic Test p-value:1.33E-11; Z-score:-2.61E+00

Methylation in Case

 2.33E-01 (Median) Methylation in Control 3.61E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.21E+00 Statistic Test p-value:7.94E-05; Z-score:1.00E+00

Methylation in Case

 2.41E-01 (Median) Methylation in Control 1.99E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.10E+00 Statistic Test p-value:6.13E-03; Z-score:2.72E-01

Methylation in Case

 2.29E-01 (Median) Methylation in Control 2.08E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 TSS200 (cg07920064)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.03E+00 Statistic Test p-value:3.94E-02; Z-score:7.78E-02

Methylation in Case

 3.56E-02 (Median) Methylation in Control 3.44E-02 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 TSS200 (cg07100128)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.01E+00 Statistic Test p-value:4.17E-02; Z-score:7.98E-02

Methylation in Case

 5.82E-02 (Median) Methylation in Control 5.74E-02 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 Body (cg22167704)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.44E+00 Statistic Test p-value:1.26E-16; Z-score:-9.74E+00

Methylation in Case

 5.59E-01 (Median) Methylation in Control 8.04E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon8

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 Body (cg19412109)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.43E+00 Statistic Test p-value:8.34E-05; Z-score:-1.12E+00

Methylation in Case

 1.03E-01 (Median) Methylation in Control 1.47E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon9

 Methylation of ABCB6 in hepatocellular carcinoma [ 8 ]

Location

 3'UTR (cg02776283)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.07E+00 Statistic Test p-value:1.76E-04; Z-score:1.13E+00

Methylation in Case

 7.07E-01 (Median) Methylation in Control 6.61E-01 (Median)

Studied Phenotype

 Hepatocellular carcinoma[ ICD-11:2C12.02]

Experimental Material

 Patient tissue samples

  Pancretic ductal adenocarcinoma

            8 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 5'UTR (cg13425422)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.01E+00 Statistic Test p-value:6.61E-03; Z-score:-2.14E-01

Methylation in Case

 8.59E-01 (Median) Methylation in Control 8.69E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 TSS1500 (cg06652199)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:4.40E+00 Statistic Test p-value:5.50E-28; Z-score:4.49E+00

Methylation in Case

 2.86E-01 (Median) Methylation in Control 6.50E-02 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 TSS1500 (cg06417752)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.20E+00 Statistic Test p-value:1.25E-07; Z-score:-1.33E+00

Methylation in Case

 2.20E-01 (Median) Methylation in Control 2.65E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 TSS1500 (cg25771897)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.03E+00 Statistic Test p-value:3.55E-02; Z-score:-1.24E-01

Methylation in Case

 1.13E-01 (Median) Methylation in Control 1.17E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 TSS200 (cg25841634)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.07E+00 Statistic Test p-value:1.05E-02; Z-score:-5.05E-01

Methylation in Case

 7.42E-02 (Median) Methylation in Control 7.96E-02 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 TSS200 (cg07920064)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:4.40E-02; Z-score:-4.11E-01

Methylation in Case

 6.21E-02 (Median) Methylation in Control 6.57E-02 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 1stExon (cg13925011)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.06E+00 Statistic Test p-value:3.37E-03; Z-score:6.16E-01

Methylation in Case

 6.95E-01 (Median) Methylation in Control 6.56E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon8

 Methylation of ABCB6 in pancretic ductal adenocarcinoma [ 2 ]

Location

 Body (cg00089550)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.09E+00 Statistic Test p-value:7.11E-03; Z-score:-7.65E-01

Methylation in Case

 3.77E-01 (Median) Methylation in Control 4.12E-01 (Median)

Studied Phenotype

 Pancretic ductal adenocarcinoma[ ICD-11:2C10.0]

Experimental Material

 Patient tissue samples

  Bladder cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in bladder cancer [ 3 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.08E+00 Statistic Test p-value:1.16E-05; Z-score:4.26E+00

Methylation in Case

 3.35E-01 (Median) Methylation in Control 1.61E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in bladder cancer [ 3 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.14E+00 Statistic Test p-value:1.26E-05; Z-score:5.40E+00

Methylation in Case

 2.92E-01 (Median) Methylation in Control 1.37E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in bladder cancer [ 3 ]

Location

 Body (cg19964303)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.06E+00 Statistic Test p-value:1.71E-05; Z-score:4.79E+00

Methylation in Case

 8.78E-01 (Median) Methylation in Control 8.25E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in bladder cancer [ 3 ]

Location

 3'UTR (cg02776283)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.24E+00 Statistic Test p-value:1.07E-03; Z-score:3.49E+00

Methylation in Case

 8.32E-01 (Median) Methylation in Control 6.70E-01 (Median)

Studied Phenotype

 Bladder cancer[ ICD-11:2C94]

Experimental Material

 Patient tissue samples

  Breast cancer

            8 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.21E+00 Statistic Test p-value:1.01E-12; Z-score:3.24E+00

Methylation in Case

 2.30E-01 (Median) Methylation in Control 1.04E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.52E+00 Statistic Test p-value:3.09E-09; Z-score:2.11E+00

Methylation in Case

 2.18E-01 (Median) Methylation in Control 1.43E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 TSS200 (cg24775454)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.22E+00 Statistic Test p-value:1.37E-02; Z-score:2.17E-01

Methylation in Case

 1.17E-02 (Median) Methylation in Control 9.60E-03 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 TSS200 (cg08290072)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.16E+00 Statistic Test p-value:2.05E-02; Z-score:1.93E-01

Methylation in Case

 9.20E-03 (Median) Methylation in Control 7.92E-03 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 TSS200 (cg18014247)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.12E+00 Statistic Test p-value:2.16E-02; Z-score:4.61E-01

Methylation in Case

 6.39E-02 (Median) Methylation in Control 5.73E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 TSS200 (cg26544277)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.12E+00 Statistic Test p-value:2.70E-02; Z-score:2.68E-01

Methylation in Case

 3.46E-02 (Median) Methylation in Control 3.08E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 Body (cg19412109)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.40E+00 Statistic Test p-value:1.03E-07; Z-score:1.51E+00

Methylation in Case

 1.34E-01 (Median) Methylation in Control 9.57E-02 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon8

 Methylation of ABCB6 in breast cancer [ 4 ]

Location

 Body (cg19964303)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.07E+00 Statistic Test p-value:4.13E-05; Z-score:8.20E-01

Methylation in Case

 8.76E-01 (Median) Methylation in Control 8.16E-01 (Median)

Studied Phenotype

 Breast cancer[ ICD-11:2C60-2C6Z]

Experimental Material

 Patient tissue samples

  Renal cell carcinoma

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in clear cell renal cell carcinoma [ 5 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.90E+00 Statistic Test p-value:6.12E-06; Z-score:1.00E+00

Methylation in Case

 1.09E-01 (Median) Methylation in Control 5.76E-02 (Median)

Studied Phenotype

 Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in clear cell renal cell carcinoma [ 5 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.03E+00 Statistic Test p-value:1.09E-05; Z-score:1.19E+00

Methylation in Case

 1.15E-01 (Median) Methylation in Control 5.66E-02 (Median)

Studied Phenotype

 Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in clear cell renal cell carcinoma [ 5 ]

Location

 1stExon (cg23547073)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.21E+00 Statistic Test p-value:2.74E-06; Z-score:1.49E+00

Methylation in Case

 4.88E-02 (Median) Methylation in Control 4.04E-02 (Median)

Studied Phenotype

 Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in clear cell renal cell carcinoma [ 5 ]

Location

 Body (cg19412109)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.74E+00 Statistic Test p-value:9.03E-06; Z-score:1.55E+00

Methylation in Case

 8.44E-02 (Median) Methylation in Control 4.84E-02 (Median)

Studied Phenotype

 Renal cell carcinoma[ ICD-11:2C90]

Experimental Material

 Patient tissue samples

  Colon cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in colon adenocarcinoma [ 6 ]

Location

 TSS1500 (cg16703956)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.29E+00 Statistic Test p-value:2.77E-06; Z-score:1.35E+00

Methylation in Case

 6.73E-01 (Median) Methylation in Control 5.22E-01 (Median)

Studied Phenotype

 Colon cancer[ ICD-11:2B90]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in colon adenocarcinoma [ 6 ]

Location

 1stExon (cg20302133)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.22E+00 Statistic Test p-value:7.58E-06; Z-score:9.13E-01

Methylation in Case

 6.69E-01 (Median) Methylation in Control 5.49E-01 (Median)

Studied Phenotype

 Colon cancer[ ICD-11:2B90]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in colon adenocarcinoma [ 6 ]

Location

 Body (cg16146033)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.30E+00 Statistic Test p-value:4.79E-06; Z-score:-1.09E+00

Methylation in Case

 2.91E-01 (Median) Methylation in Control 3.78E-01 (Median)

Studied Phenotype

 Colon cancer[ ICD-11:2B90]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in colon adenocarcinoma [ 6 ]

Location

 Body (cg05367173)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.17E+00 Statistic Test p-value:6.74E-06; Z-score:-4.91E+00

Methylation in Case

 7.35E-01 (Median) Methylation in Control 8.63E-01 (Median)

Studied Phenotype

 Colon cancer[ ICD-11:2B90]

Experimental Material

 Patient tissue samples

  Colorectal cancer

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in colorectal cancer [ 7 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.42E+00 Statistic Test p-value:3.27E-02; Z-score:-1.22E+00

Methylation in Case

 2.75E-01 (Median) Methylation in Control 3.89E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in colorectal cancer [ 7 ]

Location

 TSS200 (cg07100128)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.06E+00 Statistic Test p-value:2.49E-02; Z-score:4.57E-01

Methylation in Case

 8.34E-02 (Median) Methylation in Control 7.90E-02 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in colorectal cancer [ 7 ]

Location

 TSS200 (cg07920064)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.18E+00 Statistic Test p-value:4.39E-02; Z-score:6.41E-01

Methylation in Case

 2.69E-02 (Median) Methylation in Control 2.28E-02 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in colorectal cancer [ 7 ]

Location

 1stExon (cg23547073)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.05E+00 Statistic Test p-value:2.52E-02; Z-score:2.64E-01

Methylation in Case

 1.17E-01 (Median) Methylation in Control 1.12E-01 (Median)

Studied Phenotype

 Colorectal cancer[ ICD-11:2B91]

Experimental Material

 Patient tissue samples

  HIV infection

          10 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.27E+00 Statistic Test p-value:1.36E-09; Z-score:3.32E+00

Methylation in Case

 3.51E-01 (Median) Methylation in Control 1.55E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.57E+00 Statistic Test p-value:2.29E-07; Z-score:1.92E+00

Methylation in Case

 2.31E-01 (Median) Methylation in Control 1.47E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS200 (cg26544277)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.65E+00 Statistic Test p-value:1.47E-03; Z-score:1.26E+00

Methylation in Case

 4.68E-02 (Median) Methylation in Control 2.83E-02 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS200 (cg07920064)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.24E+00 Statistic Test p-value:1.27E-02; Z-score:7.46E-01

Methylation in Case

 4.70E-02 (Median) Methylation in Control 3.78E-02 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS200 (cg08290072)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.52E+00 Statistic Test p-value:1.39E-02; Z-score:1.45E+00

Methylation in Case

 2.26E-02 (Median) Methylation in Control 8.97E-03 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS200 (cg24775454)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:2.53E+00 Statistic Test p-value:2.92E-02; Z-score:1.15E+00

Methylation in Case

 1.55E-02 (Median) Methylation in Control 6.14E-03 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon7

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS200 (cg07100128)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.12E+00 Statistic Test p-value:3.39E-02; Z-score:6.02E-01

Methylation in Case

 6.94E-02 (Median) Methylation in Control 6.18E-02 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon8

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 TSS200 (cg18014247)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.12E+00 Statistic Test p-value:4.33E-02; Z-score:4.95E-01

Methylation in Case

 7.32E-02 (Median) Methylation in Control 6.53E-02 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon9

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 Body (cg19412109)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.29E+00 Statistic Test p-value:1.35E-04; Z-score:1.82E+00

Methylation in Case

 2.42E-01 (Median) Methylation in Control 1.88E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon10

 Methylation of ABCB6 in HIV infection [ 9 ]

Location

 3'UTR (cg02776283)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.72E+00 Statistic Test p-value:8.14E-07; Z-score:2.92E+00

Methylation in Case

 3.91E-01 (Median) Methylation in Control 2.27E-01 (Median)

Studied Phenotype

 HIV infection[ ICD-11:1C62.Z]

Experimental Material

 Patient tissue samples

  Lung adenocarcinoma

            4 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in lung adenocarcinoma [ 10 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.36E+00 Statistic Test p-value:8.20E-04; Z-score:1.97E+00

Methylation in Case

 2.64E-01 (Median) Methylation in Control 1.94E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in lung adenocarcinoma [ 10 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.54E+00 Statistic Test p-value:6.64E-03; Z-score:2.32E+00

Methylation in Case

 2.77E-01 (Median) Methylation in Control 1.80E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in lung adenocarcinoma [ 10 ]

Location

 TSS200 (cg08290072)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.56E+00 Statistic Test p-value:2.90E-02; Z-score:1.45E+00

Methylation in Case

 3.81E-02 (Median) Methylation in Control 2.45E-02 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in lung adenocarcinoma [ 10 ]

Location

 Body (cg19412109)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.44E+00 Statistic Test p-value:3.60E-04; Z-score:2.88E+00

Methylation in Case

 2.12E-01 (Median) Methylation in Control 1.47E-01 (Median)

Studied Phenotype

 Lung adenocarcinoma[ ICD-11:2C25.0]

Experimental Material

 Patient tissue samples

  Panic disorder

            2 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in panic disorder [ 11 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-8.47E-01 Statistic Test p-value:2.65E-04; Z-score:-7.56E-01

Methylation in Case

 -3.52E+00 (Median) Methylation in Control -2.98E+00 (Median)

Studied Phenotype

 Panic disorder[ ICD-11:6B01]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in panic disorder [ 11 ]

Location

 TSS200 (cg07100128)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:9.65E-01 Statistic Test p-value:7.88E-03; Z-score:4.83E-01

Methylation in Case

 -4.36E+00 (Median) Methylation in Control -4.51E+00 (Median)

Studied Phenotype

 Panic disorder[ ICD-11:6B01]

Experimental Material

 Patient tissue samples

  Papillary thyroid cancer

            6 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in papillary thyroid cancer [ 12 ]

Location

 TSS1500 (cg23153680)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.47E+00 Statistic Test p-value:1.27E-09; Z-score:2.06E+00

Methylation in Case

 2.20E-01 (Median) Methylation in Control 1.50E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in papillary thyroid cancer [ 12 ]

Location

 TSS1500 (cg06716437)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.38E+00 Statistic Test p-value:9.34E-07; Z-score:1.48E+00

Methylation in Case

 1.13E-01 (Median) Methylation in Control 8.18E-02 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in papillary thyroid cancer [ 12 ]

Location

 TSS200 (cg07100128)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.09E+00 Statistic Test p-value:4.34E-02; Z-score:4.04E-01

Methylation in Case

 5.25E-02 (Median) Methylation in Control 4.81E-02 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon4

 Methylation of ABCB6 in papillary thyroid cancer [ 12 ]

Location

 TSS200 (cg26544277)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.02E+00 Statistic Test p-value:4.66E-02; Z-score:1.36E-01

Methylation in Case

 7.06E-02 (Median) Methylation in Control 6.91E-02 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon5

 Methylation of ABCB6 in papillary thyroid cancer [ 12 ]

Location

 Body (cg19964303)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.03E+00 Statistic Test p-value:7.58E-03; Z-score:1.03E+00

Methylation in Case

 8.94E-01 (Median) Methylation in Control 8.72E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon6

 Methylation of ABCB6 in papillary thyroid cancer [ 12 ]

Location

 Body (cg00719108)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.01E+00 Statistic Test p-value:7.91E-03; Z-score:7.02E-01

Methylation in Case

 9.46E-01 (Median) Methylation in Control 9.41E-01 (Median)

Studied Phenotype

 Papillary thyroid cancer[ ICD-11:2D10.1]

Experimental Material

 Patient tissue samples

  Atypical teratoid rhabdoid tumor

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in atypical teratoid rhabdoid tumor [ 13 ]

Location

 1stExon (cg23547073)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.34E+00 Statistic Test p-value:1.02E-16; Z-score:-2.19E+00

Methylation in Case

 5.14E-01 (Median) Methylation in Control 6.90E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in atypical teratoid rhabdoid tumor [ 13 ]

Location

 Body (cg00719108)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.38E+00 Statistic Test p-value:3.64E-05; Z-score:1.23E+00

Methylation in Case

 6.89E-02 (Median) Methylation in Control 4.98E-02 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon3

 Methylation of ABCB6 in atypical teratoid rhabdoid tumor [ 13 ]

Location

 3'UTR (cg02776283)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.48E+00 Statistic Test p-value:4.33E-15; Z-score:-2.72E+00

Methylation in Case

 4.79E-01 (Median) Methylation in Control 7.10E-01 (Median)

Studied Phenotype

 Atypical teratoid rhabdoid tumor[ ICD-11:2A00.1Y]

Experimental Material

 Patient tissue samples

  Systemic lupus erythematosus

            1 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in systemic lupus erythematosus [ 14 ]

Location

 1stExon (cg23547073)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:-1.06E+00 Statistic Test p-value:4.75E-04; Z-score:-2.66E-01

Methylation in Case

 1.29E-01 (Median) Methylation in Control 1.36E-01 (Median)

Studied Phenotype

 Systemic lupus erythematosus[ ICD-11:4A40.0]

Experimental Material

 Patient tissue samples

  Prostate cancer

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 Methylation of ABCB6 in prostate cancer [ 15 ]

Location

 Body (cg21506819)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.29E+00 Statistic Test p-value:1.38E-02; Z-score:2.01E+00

Methylation in Case

 8.50E-01 (Median) Methylation in Control 6.58E-01 (Median)

Studied Phenotype

 Prostate cancer[ ICD-11:2C82]

Experimental Material

 Patient tissue samples

  Epigenetic Phenomenon2

 Methylation of ABCB6 in prostate cancer [ 15 ]

Location

 Body (cg05394840)

Epigenetic Type

 Methylation Experiment Method Infinium HumanMethylation450 BeadChip

Methylation Fold Change

 Fold Change:1.03E+00 Statistic Test p-value:3.52E-02; Z-score:1.99E+00

Methylation in Case

 9.36E-01 (Median) Methylation in Control 9.11E-01 (Median)

Studied Phenotype

 Prostate cancer[ ICD-11:2C82]

Experimental Material

 Patient tissue samples

microRNA

  Unclear Phenotype

            3 Epigenetic Phenomena Related to This Phenotype Click to Show/Hide the Full List

  Epigenetic Phenomenon1

 miR-1 directly targets ABCB6 [ 16 ]

Epigenetic Type

 microRNA Experiment Method Proteomics

miRNA Stemloop ID

 miR-1 miRNA Mature ID miR-1-3p

miRNA Sequence

 UGGAAUGUAAAGAAGUAUGUAU

miRNA Target Type

 Direct

Experimental Material

 Human cervical cancer cell line (Hela)

  Epigenetic Phenomenon2

 miR-26b directly targets ABCB6 [ 17 ]

Epigenetic Type

 microRNA Experiment Method Microarray

miRNA Stemloop ID

 miR-26b miRNA Mature ID miR-26b-5p

miRNA Sequence

 UUCAAGUAAUUCAGGAUAGGU

miRNA Target Type

 Direct

Experimental Material

 Human cervical cancer cell line (Hela)

  Epigenetic Phenomenon3

 miR-7113 directly targets ABCB6 [ 18 ]

Epigenetic Type

 microRNA Experiment Method PAR-CLIP

miRNA Stemloop ID

 miR-7113 miRNA Mature ID miR-7113-5p

miRNA Sequence

 UCCAGGGAGACAGUGUGUGAG

miRNA Target Type

 Direct

Experimental Material

 Human embryonic kidney 293 cells (HEK293)
References
1 ABCB6 mRNA and DNA methylation levels serve as useful biomarkers for prediction of early intrahepatic recurrence of hepatitis C virus-related hepatocellular carcinoma. Int J Oncol. 2013 May;42(5):1551-9.
2 Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling. Int J Cancer. 2014 Sep 1;135(5):1110-8.
3 DNA Methylation Dynamics in Urological Tumors.
4 Genome-wide Scan for Methylation Profiles in Breast Cancer
5 A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma. Nat Commun. 2015 Oct 30;6:8699.
6 Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013 Sep;8(9):921-34.
7 Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8.
8 Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics. 2013 Jan;8(1):34-43.
9 HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis. 2015 Nov 15;212(10):1563-73.
10 DNA methylation analysis of lung adenocarcinoma and adjacent non-tumor tissues
11 DNA Methylation signatures in panic disorder. Transl Psychiatry. 2017 Dec 18;7(12):1287.
12 Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4089-4099.
13 Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. 2016 Mar 14;29(3):379-393.
14 Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet. 2013;9(8):e1003678.
15 Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array. BMC Genomics. 2014 Jan 22;15:51.
16 Widespread changes in protein synthesis induced by microRNAs. Nature. 2008 Sep 4;455(7209):58-63.
17 MicroRNA target prediction by expression analysis of host genes. Genome Res. 2009 Mar;19(3):481-90.
18 Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Genes Dev. 2011 Oct 15;25(20):2173-86.

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