General Information of Drug Transporter (DT)
DT ID	DTD0052 Transporter Info
Gene Name	ABCB6
Protein Name	ATP-binding cassette sub-family B member 6
Gene ID	10058
UniProt ID	Q9NP58
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs3755047
Site of GPD	chr2:219220142 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.9590/1897 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           4 Drugs in Total
Citalopram	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Fluoxetine	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Paroxetine	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Sertraline	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Genetic Polymorphism	rs3731885
Site of GPD	chr2:219219747 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.9760/1931 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           4 Drugs in Total
Citalopram	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Fluoxetine	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Paroxetine	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Sertraline	N.A.	Drug Toxicity	Allele A is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Genetic Polymorphism	rs1109867
Site of GPD	chr2:219218731 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>T
Minor Allele Frequency	G=0.2680/530 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           4 Drugs in Total
Citalopram	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Fluoxetine	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Paroxetine	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Sertraline	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Genetic Polymorphism	rs1109866
Site of GPD	chr2:219218557 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>A / C>G / C>T
Minor Allele Frequency	C=0.2680/530 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           4 Drugs in Total
Citalopram	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele C.		[ 1]
Fluoxetine	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele C.		[ 1]
Paroxetine	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele C.		[ 1]
Sertraline	N.A.	Drug Toxicity	Allele T is not associated with response to citalopram, fluoxetine, paroxetine or sertraline in people with Depressive Disorder, Major as compared to allele C.		[ 1]
References
1	ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients. Pharmacogenomics. 2013 Nov;14(14):1723-30.

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