Drug Transporter (DT) Information

General Information of DT
DT ID DTD0036
Gene Name ABCA1
Protein Name ATP-binding cassette sub-family A member 1
Gene ID
19
UniProt ID
O95477
TCDB ID
3.A.1.211.14
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:5XJY_A

Identity:100%

Minimized Score:-1973.407 kcal/mol

Detail: Structure Info

Synonyms ABC-1; ABC1; ABCA1; ATP-binding cassette 1; ATP-binding cassette transporter 1; CERP; Cholesterol efflux regulatory protein; HDLDT1; TGD
DT Family ATP-Binding Cassette (ABC) Superfamily
Cholesterol/Phospholipid/Retinal (CPR) Flippase Family (ABCA)
Tissue Specificity Widely expressed, but most abundant inmacrophages.
Function This transporter is cAMP-dependent and sulfonylurea-sensitive. Involved in the efflux of intracellular cholesterol and phospholipids and their transfer to apoliproteins to form nascent high density lipoproteins/HDLs.
Endogenous Substrate(s) Lipids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of ATP-binding cassette sub-family A member 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of ATP-binding cassette sub-family A member 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of ATP-binding cassette sub-family A member 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of ATP-binding cassette sub-family A member 1
Microbiota Influence (MBI)

(β) Post-translational Modification of ATP-binding cassette sub-family A member 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of ATP-binding cassette sub-family A member 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of ATP-binding cassette sub-family A member 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of ATP-binding cassette sub-family A member 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of ATP-binding cassette sub-family A member 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of ATP-binding cassette sub-family A member 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Fenofibric acid
 Approved Drug Info Hypercholesterolemia 5C80.0 [1]

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Cholesterol
 Phase 2 Drug Info Cone-Rod dystrophy 9B70 [2]
References
1 Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1193-7.
2 ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions. J Lipid Res. 2003 Jul;44(7):1373-80.

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