Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0036 Transporter Info
Gene Name	ABCA1
Transporter Name	ATP-binding cassette sub-family A member 1
Gene ID	19
UniProt ID	O95477

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	ABCA1 protein alternative form affects the susceptibility to Rosiglitazone			[162]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rosiglitazone co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rosiglitazone co-treated with Atorvastatin results in increased expression of ABCA1 protein			[109]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Arsenic Trioxide inhibits the reaction Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Arsenic Trioxide inhibits the reaction Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 protein			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Arsenic Trioxide results in increased expression of ABCA1 mRNA			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rifampin results in increased expression of ABCA1 mRNA			[161]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin results in increased expression of ABCA1 protein			[161]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sirolimus co-treated with Cyclosporine results in decreased expression of ABCA1 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sirolimus co-treated with Tacrolimus results in increased expression of ABCA1 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lipopolysaccharides inhibits the reaction Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bezafibrate binds to and results in increased activity of PPARA protein promotes the reaction 25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bezafibrate binds to and results in increased activity of PPARA protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Simvastatin results in increased expression of ABCA1 mRNA			[166]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Folic Acid deficiency co-treated with Methotrexate results in increased expression of ABCA1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tretinoin results in increased expression of ABCA1 mRNA			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Folic Acid deficiency co-treated with Methotrexate results in increased expression of ABCA1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Methotrexate inhibits the reaction IFNG protein results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Methotrexate inhibits the reaction N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ZM 241385 inhibits the reaction Methotrexate inhibits the reaction IFNG protein results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ZM 241385 inhibits the reaction Methotrexate inhibits the reaction N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ZM 241385 inhibits the reaction Methotrexate results in increased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sirolimus co-treated with Cyclosporine results in decreased expression of ABCA1 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of ABCA1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid results in increased expression of ABCA1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid results in increased methylation of ABCA1 gene			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clofibrate affects the expression of ABCA1 protein			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Clofibrate results in increased expression of ABCA1 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Clofibrate results in increased expression of ABCA1 protein			[123]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	PPARA protein affects the reaction Clofibrate results in increased expression of ABCA1 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with TGFB1 protein results in increased expression of ABCA1 mRNA			[137]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pioglitazone affects the expression of ABCA1 protein			[122]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Genistein co-treated with daidzein co-treated with glycitein results in decreased expression of ABCA1 mRNA			[129]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol which results in increased expression of ABCA1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NPC1 protein affects the reaction Fingolimod Hydrochloride results in increased expression of ABCA1 protein			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	UVI 3003 inhibits the reaction Fingolimod Hydrochloride results in increased expression of ABCA1 protein			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCA1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ethanol results in increased expression of ABCA1 protein			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	IGF1 protein inhibits the reaction Ethanol results in decreased expression of ABCA1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	IGF1 protein inhibits the reaction Ethanol results in decreased expression of ABCA1 protein			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	MIR200C mRNA affects the reaction Dibutyl Phthalate results in decreased expression of ABCA1 protein			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol which results in increased expression of ABCA1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of ABCA1 5' UTR			[110]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of ABCA1 promoter			[110]
Regulation Mechanism				Transcription Factor Info
1,2-linoleoylphosphatidylcholine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1,2-linoleoylphosphatidylcholine results in decreased expression of ABCA1 protein			[83]
Regulation Mechanism				Transcription Factor Info
1-Butanol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Butanol inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of ABCA1 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
1-oleoyl-2-acetylglycerol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-oleoyl-2-acetylglycerol inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	1-oleoyl-2-acetylglycerol results in increased phosphorylation of and results in decreased expression of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ABCA1 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
22-hydroxycholesterol	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	22-hydroxycholesterol co-treated with Alitretinoin results in increased expression of ABCA1 protein			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	22-hydroxycholesterol results in increased expression of ABCA1 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 protein			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Arsenic Trioxide inhibits the reaction Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Arsenic Trioxide inhibits the reaction Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 protein			[89]
Regulation Mechanism				Transcription Factor Info
24,25-epoxycholesterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	24,25-epoxycholesterol results in increased expression of ABCA1 mRNA			[90]
Regulation Mechanism				Transcription Factor Info
24-hydroxycholesterol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	24-hydroxycholesterol results in increased expression of ABCA1 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	24-hydroxycholesterol results in increased expression of ABCA1 protein			[91]
Regulation Mechanism				Transcription Factor Info
25-hydroxycholesterol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	25-hydroxycholesterol co-treated with Alitretinoin results in increased expression of ABCA1 protein			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein promotes the reaction 25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Bezafibrate binds to and results in increased activity of PPARA protein promotes the reaction 25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
2-chloro-5-nitrobenzanilide	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-chloro-5-nitrobenzanilide inhibits the reaction Resveratrol results in increased expression of ABCA1 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-chloro-5-nitrobenzanilide inhibits the reaction Resveratrol results in increased expression of ABCA1 protein			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	2-chloro-5-nitrobenzanilide results in decreased expression of ABCA1 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	2-chloro-5-nitrobenzanilide results in decreased expression of ABCA1 protein			[94]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of ABCA1 mRNA			[95]
Regulation Mechanism				Transcription Factor Info
3,4,5,3',4'-pentachlorobiphenyl	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,4,5,3',4'-pentachlorobiphenyl affects the expression of ABCA1 mRNA			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ABCA1 mRNA			[96]
Regulation Mechanism				Transcription Factor Info
3-aminobenzamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-aminobenzamide promotes the reaction T0901317 results in increased expression of ABCA1 mRNA			[97]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCA1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ro 31-8220 inhibits the reaction 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein			[58]
Regulation Mechanism				Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ABCA1 protein			[87]
Regulation Mechanism				Transcription Factor Info
9-deoxy-delta-9-prostaglandin D2	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein promotes the reaction 25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
Acetylcysteine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 protein			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetylcysteine inhibits the reaction sodium arsenite results in increased methylation of ABCA1 promoter			[73]
Regulation Mechanism				Transcription Factor Info
afuresertib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afuresertib results in decreased expression of ABCA1 mRNA			[100]
Regulation Mechanism				Transcription Factor Info
Alitretinoin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	22-hydroxycholesterol co-treated with Alitretinoin results in increased expression of ABCA1 protein			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	25-hydroxycholesterol co-treated with Alitretinoin results in increased expression of ABCA1 protein			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 protein			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Arsenic Trioxide inhibits the reaction Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Arsenic Trioxide inhibits the reaction Alitretinoin co-treated with 22-hydroxycholesterol results in increased expression of ABCA1 protein			[89]
Regulation Mechanism				Transcription Factor Info
amentoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	amentoflavone inhibits the reaction malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein			[101]
Regulation Mechanism				Transcription Factor Info
Arachidonic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arachidonic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Arachidonic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Phospholipids			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Arachidonic Acid results in increased degradation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
aranidipine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aranidipine results in increased expression of ABCA1 protein			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction aranidipine results in increased expression of ABCA1 protein			[13]
Regulation Mechanism				Transcription Factor Info
archazolid B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	archazolid B results in decreased expression of ABCA1 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
Ascorbic Acid	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bexarotene co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	diazepinylbenzoic acid co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in decreased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	diazepinylbenzoic acid inhibits the reaction LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	diazepinylbenzoic acid inhibits the reaction tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Quercetin co-treated with Ascorbic Acid results in decreased expression of ABCA1 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Rosiglitazone co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	T0901317 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
atheronal-A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	atheronal-A inhibits the reaction T0901317 results in increased expression of ABCA1 mRNA			[108]
Regulation Mechanism				Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in decreased expression of ABCA1 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
beauvericin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beauvericin co-treated with enniatins results in decreased expression of ABCA1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
beta-glycerophosphoric acid	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bexarotene co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	diazepinylbenzoic acid co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in decreased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	diazepinylbenzoic acid inhibits the reaction LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	diazepinylbenzoic acid inhibits the reaction tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Rosiglitazone co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	T0901317 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
Bexarotene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bexarotene co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of ABCA1 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in decreased expression of ABCA1 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
bis(tri-n-butyltin)oxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bis(tri-n-butyltin)oxide results in increased expression of ABCA1 mRNA			[111]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCA1 mRNA			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased expression of ABCA1 mRNA			[113]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to ABCA1 gene			[114]
Regulation Mechanism				Transcription Factor Info
chloroquine diphosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chloroquine diphosphate results in decreased expression of ABCA1 mRNA			[115]
Regulation Mechanism				Transcription Factor Info
Cholesterol	20 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Butanol inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	1-oleoyl-2-acetylglycerol inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCA1 protein results in increased export of Cholesterol			[116]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	APOA1 protein promotes the reaction ABCA1 protein results in increased export of Cholesterol			[116]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Arachidonic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	glycolaldehyde inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[116]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Glyoxal inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[116]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	HCAR2 protein results in decreased expression of ABCA1 protein which results in decreased export of Cholesterol			[117]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Linoleic Acid inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Linoleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	mastoparan inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	MDCO-216 promotes the reaction ABCA1 protein results in increased transport of Cholesterol			[118]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Oleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	palmitoleic acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	PLD2 protein affects the reaction APOA1 protein affects the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	PLD2 protein inhibits the reaction Linoleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Resveratrol results in increased expression of ABCA1 protein which results in increased secretion of Cholesterol			[119]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	triacsin C inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in increased expression of ABCA1 mRNA			[121]
Regulation Mechanism				Transcription Factor Info
Colforsin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin promotes the reaction Diethylhexyl Phthalate results in decreased expression of ABCA1 mRNA			[124]
Regulation Mechanism				Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in increased expression of ABCA1 mRNA			[125]
Regulation Mechanism				Transcription Factor Info
cordycepin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cordycepin results in increased expression of ABCA1 mRNA			[126]
Regulation Mechanism				Transcription Factor Info
cyproconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyproconazole results in decreased expression of ABCA1 mRNA			[128]
Regulation Mechanism				Transcription Factor Info
daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein co-treated with daidzein co-treated with glycitein results in decreased expression of ABCA1 mRNA			[129]
Regulation Mechanism				Transcription Factor Info
Decitabine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Decitabine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 protein			[73]
Regulation Mechanism				Transcription Factor Info
Dexamethasone	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bexarotene co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	diazepinylbenzoic acid co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in decreased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	diazepinylbenzoic acid inhibits the reaction LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	diazepinylbenzoic acid inhibits the reaction tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Rosiglitazone co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	T0901317 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
diallyl trisulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diallyl trisulfide results in decreased expression of ABCA1 mRNA			[132]
Regulation Mechanism				Transcription Factor Info
diazepinylbenzoic acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diazepinylbenzoic acid co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in decreased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	diazepinylbenzoic acid inhibits the reaction LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	diazepinylbenzoic acid inhibits the reaction tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
Diethylhexyl Phthalate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin promotes the reaction Diethylhexyl Phthalate results in decreased expression of ABCA1 mRNA			[124]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diethylhexyl Phthalate results in decreased expression of ABCA1 mRNA			[133]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Diethylhexyl Phthalate results in decreased expression of ABCA1 protein			[124]
Regulation Mechanism				Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of ABCA1 mRNA			[134]
Regulation Mechanism				Transcription Factor Info
Disulfiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram binds to Copper which results in increased expression of ABCA1 mRNA			[125]
Regulation Mechanism				Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Docetaxel results in decreased susceptibility to Docetaxel which results in increased expression of ABCA1 mRNA			[135]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCA1 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
efonidipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	efonidipine results in increased expression of ABCA1 protein			[13]
Regulation Mechanism				Transcription Factor Info
Eicosapentaenoic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eicosapentaenoic Acid results in decreased expression of ABCA1 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
enniatins	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beauvericin co-treated with enniatins results in decreased expression of ABCA1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	enniatins results in decreased expression of ABCA1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
epigallocatechin gallate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate results in increased expression of ABCA1 mRNA			[136]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	epigallocatechin gallate results in increased expression of ABCA1 protein			[136]
Regulation Mechanism				Transcription Factor Info
fatostatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGA protein inhibits the reaction fatostatin promotes the reaction T0901317 results in increased expression of ABCA1 mRNA			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	fatostatin promotes the reaction T0901317 results in increased expression of ABCA1 mRNA			[138]
Regulation Mechanism				Transcription Factor Info
fenpyroximate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fenpyroximate results in increased expression of ABCA1 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Fluoxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluoxetine results in decreased expression of ABCA1 mRNA			[139]
Regulation Mechanism				Transcription Factor Info
Fluvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP affects the susceptibility to Fluvastatin			[140]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP affects the susceptibility to Fluvastatin			[140]
Regulation Mechanism				Transcription Factor Info
Fonofos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fonofos results in increased methylation of ABCA1 promoter			[141]
Regulation Mechanism				Transcription Factor Info
Gasoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of ABCA1 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
glycitein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein co-treated with daidzein co-treated with glycitein results in decreased expression of ABCA1 mRNA			[129]
Regulation Mechanism				Transcription Factor Info
glycolaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glycolaldehyde inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[116]
Regulation Mechanism				Transcription Factor Info
Glyoxal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glyoxal inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[116]
Regulation Mechanism				Transcription Factor Info
GSK 3987	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK 3987 results in increased expression of ABCA1 mRNA			[142]
Regulation Mechanism				Transcription Factor Info
GW 3965	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCA1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCA1 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	GW 3965 results in increased expression of ABCA1 mRNA			[142]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	GW 3965 results in increased expression of ABCA1 protein			[143]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NR1H3 mutant form inhibits the reaction GW 3965 results in increased expression of ABCA1 mRNA			[144]
Regulation Mechanism				Transcription Factor Info
GW 4064	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 4064 results in decreased expression of ABCA1 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
GW 501516	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 501516 results in increased expression of ABCA1 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GW 501516 results in increased expression of ABCA1 protein			[17]
Regulation Mechanism				Transcription Factor Info
GW 6471	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 6471 inhibits the reaction pitavastatin results in increased expression of ABCA1 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
Hexachlorocyclohexane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hexachlorocyclohexane results in increased expression of ABCA1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
isosilybin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	isosilybin A results in increased expression of ABCA1 protein			[145]
Regulation Mechanism				Transcription Factor Info
LG 100268	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diazepinylbenzoic acid inhibits the reaction LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	LG 100268 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
licochalcone B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	licochalcone B results in decreased expression of ABCA1 mRNA			[146]
Regulation Mechanism				Transcription Factor Info
Linoleic Acid	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Butanol inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Linoleic Acid inhibits the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Linoleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Linoleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Phospholipids			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Linoleic Acid results in increased degradation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Linoleic Acid results in increased phosphorylation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	PLD2 protein inhibits the reaction Linoleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	triacsin C inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	triacsin C inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased transport of Phospholipids			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	triacsin C inhibits the reaction Linoleic Acid results in increased degradation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
LY 518674	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LY 518674 results in increased expression of ABCA1 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	LY 518674 results in increased expression of ABCA1 protein			[17]
Regulation Mechanism				Transcription Factor Info
Malondialdehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	iron(II)-ascorbic acid complex promotes the reaction Malondialdehyde results in increased expression of ABCA1 protein			[58]
Regulation Mechanism				Transcription Factor Info
mastoparan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mastoparan inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased export of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	mastoparan results in increased phosphorylation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of ABCA1 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of ABCA1 mRNA			[147]
Regulation Mechanism				Transcription Factor Info
Mitoxantrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCA1 protein affects the susceptibility to Mitoxantrone			[148]
Regulation Mechanism				Transcription Factor Info
MRK 003	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MRK 003 results in increased expression of ABCA1 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction aranidipine results in increased expression of ABCA1 protein			[13]
Regulation Mechanism				Transcription Factor Info
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the reaction N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ZM 241385 inhibits the reaction Methotrexate inhibits the reaction N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
Niacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chromium co-treated with Niacin results in decreased expression of ABCA1 mRNA			[120]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Niacin results in increased expression of ABCA1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in increased expression of ABCA1 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
Nicotine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCA1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GW 3965 inhibits the reaction Nicotine results in decreased expression of ABCA1 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Nicotine results in decreased expression of ABCA1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Nicotine results in decreased expression of ABCA1 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCA1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCA1 protein			[30]
Regulation Mechanism				Transcription Factor Info
NSC305787	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC305787 results in increased expression of ABCA1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
nutlin 3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nutlin 3 results in increased expression of ABCA1 mRNA			[149]
Regulation Mechanism				Transcription Factor Info
obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	obeticholic acid results in decreased expression of ABCA1 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of ABCA1 mRNA			[150]
Regulation Mechanism				Transcription Factor Info
Oleic Acid	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Oleic Acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Phospholipids			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Oleic Acid results in increased degradation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Oleic Acid results in increased phosphorylation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Palmitic Acid co-treated with Oleic Acid affects the expression of ABCA1 mRNA			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein affects the expression of ABCA1 mRNA			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Palmitic Acid co-treated with Oleic Acid results in decreased expression of ABCA1 mRNA			[128]
Regulation Mechanism				Transcription Factor Info
Oxygen	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MIR20A mRNA affects the reaction Oxygen deficiency affects the expression of ABCA1 protein			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Oxygen deficiency affects the expression of ABCA1 protein			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Oxygen deficiency results in decreased expression of ABCA1 mRNA			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Oxygen deficiency results in increased expression of ABCA1 mRNA			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Oxygen results in increased expression of ABCA1 mRNA			[155]
Regulation Mechanism				Transcription Factor Info
Ozone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ozone inhibits the reaction T0901317 results in increased expression of ABCA1 mRNA			[108]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ozone results in decreased expression of ABCA1 mRNA			[108]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ozone results in decreased expression of ABCA1 protein			[108]
Regulation Mechanism				Transcription Factor Info
Palmitic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid co-treated with Oleic Acid affects the expression of ABCA1 mRNA			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein affects the expression of ABCA1 mRNA			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Palmitic Acid co-treated with Oleic Acid results in decreased expression of ABCA1 mRNA			[128]
Regulation Mechanism				Transcription Factor Info
palmitoleic acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	palmitoleic acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	palmitoleic acid inhibits the reaction APOA1 protein affects the reaction ABCA1 protein results in increased transport of Phospholipids			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	palmitoleic acid results in increased degradation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	palmitoleic acid results in increased phosphorylation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
Paraoxon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paraoxon results in decreased expression of ABCA1 protein			[66]
Regulation Mechanism				Transcription Factor Info
Parathion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Parathion results in increased methylation of ABCA1 promoter			[141]
Regulation Mechanism				Transcription Factor Info
perfluorobutanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorobutanesulfonic acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
perfluorobutyric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorobutyric acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
perfluorodecanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorodecanoic acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
perfluorododecanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorododecanoic acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
perfluorohexanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorohexanoic acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
perfluoro-n-heptanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-heptanoic acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
perfluorooctanesulfonamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanesulfonamide analog results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanesulfonamide results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased expression of ABCA1 mRNA			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctane sulfonic acid results in increased expression of ABCA1 mRNA			[157]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased expression of ABCA1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
perfluoroundecanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoroundecanoic acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in decreased expression of ABCA1 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in increased expression of ABCA1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
pitavastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 6471 inhibits the reaction pitavastatin results in increased expression of ABCA1 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pitavastatin results in increased expression of ABCA1 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	PPARA protein affects the reaction pitavastatin results in increased expression of ABCA1 mRNA			[123]
Regulation Mechanism				Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in increased expression of ABCA1 mRNA			[158]
Regulation Mechanism				Transcription Factor Info
prothioconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	prothioconazole results in decreased expression of ABCA1 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
quinocetone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quinocetone results in increased expression of ABCA1 mRNA			[160]
Regulation Mechanism				Transcription Factor Info
Ro 31-8220	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ro 31-8220 inhibits the reaction 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate results in increased expression of ABCA1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ro 31-8220 results in decreased expression of ABCA1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of ABCA1 mRNA			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in increased expression of ABCA1 mRNA			[163]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of ABCA1 mRNA			[164]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silicon Dioxide results in decreased expression of ABCA1 mRNA			[165]
Regulation Mechanism				Transcription Factor Info
Silybin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin results in increased expression of ABCA1 protein			[145]
Regulation Mechanism				Transcription Factor Info
silychristin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	silychristin results in increased expression of ABCA1 protein			[145]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 protein			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetylcysteine inhibits the reaction sodium arsenite results in increased methylation of ABCA1 promoter			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Decitabine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Decitabine inhibits the reaction sodium arsenite results in decreased expression of ABCA1 protein			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	sodium arsenite results in decreased expression of ABCA1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	sodium arsenite results in decreased expression of ABCA1 protein			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	sodium arsenite results in increased abundance of Arsenic which results in increased expression of ABCA1 mRNA			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	sodium arsenite results in increased methylation of ABCA1 promoter			[73]
Regulation Mechanism				Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in increased expression of ABCA1 mRNA			[167]
Regulation Mechanism				Transcription Factor Info
sulfluramid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulfluramid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
T0901317	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-aminobenzamide promotes the reaction T0901317 results in increased expression of ABCA1 mRNA			[97]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	atheronal-A inhibits the reaction T0901317 results in increased expression of ABCA1 mRNA			[108]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	CGA protein inhibits the reaction fatostatin promotes the reaction T0901317 results in increased expression of ABCA1 mRNA			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	CGA protein inhibits the reaction T0901317 results in increased expression of ABCA1 mRNA			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	CGA protein inhibits the reaction T0901317 results in increased expression of ABCA1 protein			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	DDT inhibits the reaction T0901317 results in increased expression of ABCA1 protein			[130]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	fatostatin promotes the reaction T0901317 results in increased expression of ABCA1 mRNA			[138]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	GH1 protein co-treated with T0901317 results in increased expression of ABCA1 mRNA			[168]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Ozone inhibits the reaction T0901317 results in increased expression of ABCA1 mRNA			[108]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	PARP1 protein inhibits the reaction T0901317 results in increased expression of ABCA1 mRNA			[97]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	T0901317 co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	T0901317 results in increased expression of ABCA1 mRNA			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	T0901317 results in increased expression of ABCA1 protein			[161]
Regulation Mechanism				Transcription Factor Info
Tacrolimus	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sirolimus co-treated with Tacrolimus results in increased expression of ABCA1 protein			[15]
Regulation Mechanism				Transcription Factor Info
terbufos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	terbufos results in increased methylation of ABCA1 promoter			[141]
Regulation Mechanism				Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in increased expression of ABCA1 mRNA			[170]
Regulation Mechanism				Transcription Factor Info
tetramethylpyrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetramethylpyrazine results in increased expression of ABCA1 protein			[69]
Regulation Mechanism				Transcription Factor Info
Thalidomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCA1 gene SNP results in increased susceptibility to Thalidomide			[171]
Regulation Mechanism				Transcription Factor Info
trans-10,cis-12-conjugated linoleic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trans-10,cis-12-conjugated linoleic acid results in decreased expression of ABCA1 mRNA			[172]
Regulation Mechanism				Transcription Factor Info
triacsin C	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triacsin C inhibits the reaction Fatty Acids results in increased degradation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	triacsin C inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased transport of Cholesterol			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	triacsin C inhibits the reaction Linoleic Acid inhibits the reaction ABCA1 protein results in increased transport of Phospholipids			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	triacsin C inhibits the reaction Linoleic Acid results in increased degradation of ABCA1 protein			[84]
Regulation Mechanism				Transcription Factor Info
tributyltin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diazepinylbenzoic acid inhibits the reaction tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tributyltin co-treated with Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein results in increased expression of ABCA1 protein			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	tributyltin results in increased expression of ABCA1 mRNA			[111]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	UVI 3003 inhibits the reaction tributyltin results in increased expression of ABCA1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in decreased expression of ABCA1 mRNA			[174]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of ABCA1 mRNA			[134]
Regulation Mechanism				Transcription Factor Info
triphenyltin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyltin chloride results in increased abundance of triphenyltin which results in increased expression of ABCA1 mRNA			[175]
Regulation Mechanism				Transcription Factor Info
triphenyltin chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyltin chloride results in increased abundance of triphenyltin which results in increased expression of ABCA1 mRNA			[175]
Regulation Mechanism				Transcription Factor Info
UVI 3003	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	UVI 3003 inhibits the reaction Fingolimod Hydrochloride results in increased expression of ABCA1 protein			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	UVI 3003 inhibits the reaction tributyltin results in increased expression of ABCA1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
Vecuronium Bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCA1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Vecuronium Bromide inhibits the reaction Nicotine results in decreased expression of ABCA1 protein			[30]
Regulation Mechanism				Transcription Factor Info
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine results in decreased susceptibility to Vincristine which results in increased expression of ABCA1 mRNA			[135]
Regulation Mechanism				Transcription Factor Info
zinc chromate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zinc chromate results in increased abundance of chromium hexavalent ion which results in increased expression of ABCA1 mRNA			[121]
Regulation Mechanism				Transcription Factor Info
ZM 241385	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ZM 241385 inhibits the reaction Methotrexate inhibits the reaction IFNG protein results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ZM 241385 inhibits the reaction Methotrexate inhibits the reaction N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ZM 241385 inhibits the reaction Methotrexate results in increased expression of ABCA1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ZM 241385 inhibits the reaction Resveratrol results in increased expression of ABCA1 protein			[94]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of ABCA1 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Probucol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probucol inhibits the activity of ABCA1			[1]
Rosiglitazone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone increases the expression of ABCA1			[2]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	Human type 2 diabetes adipose stem cell-derived adipocytes
Lansoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lansoprazole increases the expression of ABCA1			[3]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Monkey fibroblast (COS-7)
Gemfibrozil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemfibrozil increases the expression of ABCA1			[4]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor alpha (PPARA)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Pitavastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pitavastatin increases the expression of ABCA1			[5]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor alpha (PPARA)			Transcription Factor Info
Cell System	rat hepatoma cells (McARH7777)
Testosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone increases the expression of ABCA1			[6]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Human childhood acute monocytic leukemia cells (THP-1)
Arsenic Trioxide	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide inhibits the expression of ABCA1			[7]
Regulation Mechanism	via the inhibition of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Human macrophages (THP-1)
Troglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone increases the expression of ABCA1			[8]
Aspirin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin inhibits the expression of ABCA1			[9]
DT Modulation2	Aspirin results in increased expression of ABCA1 mRNA			[107]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aspirin results in increased expression of ABCA1 protein			[107]
Regulation Mechanism				Transcription Factor Info
Rifampin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of ABCA1			[10]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of ABCA1			[11]
Ezetimibe	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ezetimibe inhibits the expression of ABCA1			[12]
Atorvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the expression of ABCA1			[14]
DT Modulation2	Rosiglitazone co-treated with Atorvastatin results in increased expression of ABCA1 protein			[109]
Regulation Mechanism				Transcription Factor Info
Sirolimus	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sirolimus increases the expression of ABCA1			[15]
Rosuvastatin Calcium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosuvastatin Calcium inhibits the expression of ABCA1			[16]
Lovastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lovastatin increases the expression of ABCA1			[18]
Pravastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin inhibits the expression of ABCA1			[19]
Simvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the expression of ABCA1			[19]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of ABCA1			[20]
Omeprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Omeprazole increases the expression of ABCA1			[3]
Pantoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pantoprazole increases the expression of ABCA1			[3]
Dasatinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dasatinib increases the expression of ABCA1			[21]
Folic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Folic Acid increases the expression of ABCA1			[22]
palbociclib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	palbociclib increases the expression of ABCA1			[23]
Lindane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lindane increases the expression of ABCA1			[24]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of ABCA1			[25]
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vorinostat inhibits the expression of ABCA1			[26]
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen increases the expression of ABCA1			[27]
Obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Obeticholic acid inhibits the expression of ABCA1			[28]
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiodarone inhibits the expression of ABCA1			[29]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine polacrilex inhibits the expression of ABCA1			[30]
Tretinoin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of ABCA1			[31]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of ABCA1			[32]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Temozolomide inhibits the expression of ABCA1			[33]
Methotrexate	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of ABCA1			[35]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of ABCA1			[36]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ABCA1			[37]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of ABCA1			[38]
Propofol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propofol induces the activity of ABCA1			[39]
Rofecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rofecoxib inhibits the activity of ABCA1			[40]
Haloperidol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Haloperidol induces the activity of ABCA1			[41]
Fenofibric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibric acid induces the activity of ABCA1			[42]
Clofibrate	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clofibrate induces the activity of ABCA1			[43]
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of ABCA1			[44]
Regulation Mechanism	via enhancement of Estrogen receptor beta (ESR2)			Transcription Factor Info
Affected Drug/Substrate	Cholesterol	Modulation Type	Inducer
Cell System	C57BL/6 mice vascular smooth muscle cells
Pioglitazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pioglitazone increases the expression of ABCA1			[45]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Affected Drug/Substrate	Cholesterol	Modulation Type	Inducer
Cell System	Human gallbladder isolates
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibrate increases the expression of ABCA1			[46]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor alpha (PPARA)			Transcription Factor Info
Affected Drug/Substrate	Gefitinib	Modulation Type	Inducer
Cell System	Human non-small cell lung cancer cells (H1975
Drug Marketed but not Approved by US FDA
Efonidipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Efonidipine increases the expression of ABCA1			[13]
Bezafibrate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bezafibrate increases the expression of ABCA1			[17]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone inhibits the expression of ABCA1			[34]
Drug in Phase 3 Trial
Resveratrol	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of ABCA1			[52]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Human childhood acute monocytic leukemia cells (THP-1)
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate inhibits the expression of ABCA1			[176]
Regulation Mechanism	via the inhibition of Sterol regulatory element-binding protein 2 (SREBF2)			Transcription Factor Info
Affected Drug/Substrate	Cholesterol	Modulation Type	Inhibition
Cell System	Wistar rats
Drug in Phase 2 Trial
Genistein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of ABCA1			[48]
Regulation Mechanism	via the inhibition of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of ABCA1			[71]
Ethanol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol inhibits the expression of ABCA1			[74]
Drug in Phase 1 Trial
Fingolimod Hydrochloride	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fingolimod Hydrochloride increases the expression of ABCA1			[49]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Human primary macrophages
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of ABCA1			[53]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	ApoE deficient mice
Quercetin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin increases the expression of ABCA1			[54]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	Human childhood acute monocytic leukemia cells (THP-1)
Butylated Hydroxytoluene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butylated Hydroxytoluene increases the expression of ABCA1			[58]
NS-398	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NS-398 inhibits the expression of ABCA1			[60]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of ABCA1			[73]
Nicotinic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotinic acid increases the expression of ABCA1			[177]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Affected Drug/Substrate	Cholesterol	Modulation Type	Inducer
Cell System	human hepatocytes (HepG2)
Drug in Preclinical Test
MRK-003	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MRK-003 increases the expression of ABCA1			[61]
Tetramethylpyrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethylpyrazine increases the expression of ABCA1			[69]
Perfluorododecanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorododecanoic acid increases the expression of ABCA1			[78]
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of ABCA1			[81]
Investigative Drug
GW9662	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW9662 inhibits the expression of ABCA1			[47]
Regulation Mechanism	via the inhibition of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	Human coronary artery disease plasma sample
Lithocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lithocholic Acid inhibits the expression of ABCA1			[10]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Tributyltin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tributyltin increases the expression of ABCA1			[51]
Regulation Mechanism	via enhancement of Retinoic acid receptor RXR-alpha (RXRA)			Transcription Factor Info
Cell System	Human ovarian theca cells
CS-6969	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CS-6969 increases the expression of ABCA1			[56]
MPC1304	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MPC1304 increases the expression of ABCA1			[13]
Icosapentum	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Icosapentum inhibits the expression of ABCA1			[57]
Archazolid B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Archazolid B inhibits the expression of ABCA1			[65]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of ABCA1			[67]
NSC-305787	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NSC-305787 increases the expression of ABCA1			[68]
27-hydroxycholesterol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	27-hydroxycholesterol increases the expression of ABCA1			[79]
Patented Pharmaceutical Agent
TO-901317	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TO-901317 increases the expression of ABCA1			[50]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Chinese hamster ovary epithelial cells (CHO)
GW-3965	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW-3965 increases the expression of ABCA1			[55]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	Sprague-Dawley liver isolates
GW-4064	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW-4064 inhibits the expression of ABCA1			[75]
Natural Product
DT Modulation1	2-chloro-5-nitrobenzanilide inhibits the reaction Resveratrol results in increased expression of ABCA1 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-chloro-5-nitrobenzanilide inhibits the reaction Resveratrol results in increased expression of ABCA1 protein			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ADORA2A protein promotes the reaction Resveratrol results in increased expression of ABCA1 protein			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	PPARG protein promotes the reaction Resveratrol results in increased expression of ABCA1 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	PPARG protein promotes the reaction Resveratrol results in increased expression of ABCA1 protein			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Resveratrol results in increased expression of ABCA1 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Resveratrol results in increased expression of ABCA1 protein			[119]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Resveratrol results in increased expression of ABCA1 protein which results in increased secretion of Cholesterol			[119]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	ZM 241385 inhibits the reaction Resveratrol results in increased expression of ABCA1 protein			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Quercetin co-treated with Ascorbic Acid results in decreased expression of ABCA1 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quercetin results in increased expression of ABCA1 mRNA			[136]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quercetin results in increased expression of ABCA1 protein			[136]
Regulation Mechanism				Transcription Factor Info
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of ABCA1			[76]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of ABCA1			[80]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of ABCA1			[82]
Curcumin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin inhibits the reaction malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Curcumin inhibits the reaction malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	MIR125A mRNA inhibits the reaction Curcumin inhibits the reaction malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	MIR125A mRNA inhibits the reaction Curcumin inhibits the reaction malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SIRT6 protein promotes the reaction Curcumin inhibits the reaction malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA			[127]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SIRT6 protein promotes the reaction Curcumin inhibits the reaction malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein			[127]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Zinc	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc increases the expression of ABCA1			[63]
Perfluorohexanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorohexanoic acid increases the expression of ABCA1			[78]
Mycotoxins
Aflatoxin B1	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of ABCA1			[62]
DT Modulation2	Aflatoxin B1 affects the expression of ABCA1 protein			[98]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of ABCA1 exon			[99]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Aflatoxin B1 results in increased methylation of ABCA1 intron			[99]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel chloride increases the expression of ABCA1			[59]
Mercury	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mercury affects the expression of ABCA1			[64]
Enniatins	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enniatins inhibits the expression of ABCA1			[72]
Perfluorodecanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorodecanoic acid increases the expression of ABCA1			[78]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ABCA1			[76]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCA1 protein affects the susceptibility to Arsenic			[102]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in increased expression of ABCA1 mRNA			[103]
Regulation Mechanism				Transcription Factor Info
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCA1 mRNA			[112]
Regulation Mechanism				Transcription Factor Info
Chromium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chromium co-treated with Niacin results in decreased expression of ABCA1 mRNA			[120]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chromium results in increased expression of ABCA1 mRNA			[120]
Regulation Mechanism				Transcription Factor Info
Fungicide
Polyhexamethyleneguanidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polyhexamethyleneguanidine affects the expression of ABCA1			[70]
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin inhibits the expression of ABCA1			[34]
Pesticide/Insecticide
Ethyl paraoxon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl paraoxon inhibits the expression of ABCA1			[66]
DDT	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DDT inhibits the reaction T0901317 results in increased expression of ABCA1 protein			[130]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	DDT results in decreased expression of ABCA1 protein			[131]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
Dibutyl Phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dibutyl Phthalate inhibits the expression of ABCA1			[77]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the expression of ABCA1			[36]

References
1	Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation. J Atheroscler Thromb. 2019 May 14.
2	Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell Stem Cell. 2019 Feb 7;24(2):299-308.e6.
3	Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochem Pharmacol. 2010 May 1;79(9):1310-6.
4	Effects of fibrate drugs on expression of ABCA1 and HDL biogenesis in hepatocytes. J Cardiovasc Pharmacol. 2008 Mar;51(3):258-66.
5	Pitavastatin increases ABCA1 expression by dual mechanisms: SREBP2-driven transcriptional activation and PPARalpha-dependent protein stabilization but without activating LXR in rat hepatoma McARH7777 cells. J Pharmacol Sci. 2011;116(1):107-15.
6	Testosterone stimulates cholesterol clearance from human macrophages by activating LXRalpha. Life Sci. 2021 Mar 15;269:119040.
7	Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36.
8	Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7.
9	Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol. 2004 Feb 1;67(3):411-9.
10	Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41.
11	Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
12	Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12.
13	Divergent action of calcium channel blockers on ATP-binding cassette protein expression. J Cardiovasc Pharmacol. 2005 Dec;46(6):787-93.
14	Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes. Biochem Pharmacol. 2006 Feb 28;71(5):605-14.
15	The pharmacodynamic effects of sirolimus and sirolimus-calcineurin inhibitor combinations on macrophage scavenger and nuclear hormone receptors. J Pharm Sci. 2007 Jan;96(1):209-22.
16	In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
17	On the mechanism for PPAR agonists to enhance ABCA1 gene expression. Atherosclerosis. 2009 Aug;205(2):413-9.
18	Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. Biochem J. 2009 May 13;420(2):305-15.
19	Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102.
20	Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
21	Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
22	Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92.
23	Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48.
24	Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
25	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
26	Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
27	Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) Gamma-DEPENDENT MECHANISM. J Biol Chem. 2016 Aug 12;291(33):16977-89.
28	Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
29	Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone. Toxicol Lett. 2018 Mar 1;284:184-194.
30	Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicol Lett. 2018 Oct 15;296:31-38.
31	Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804.
32	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
33	Temozolomide induces activation of Wnt/beta-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278.
34	Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615.
35	Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
36	Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells. Arch Toxicol. 2020 May;94(5):1673-1686.
37	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
38	Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
39	Propofol Suppresses Proinflammatory Cytokine Production by Increasing ABCA1 Expression via Mediation by the Long Noncoding RNA LOC286367. Mediators Inflamm. 2018 Dec 17;2018:8907143.
40	COX-2-dependent and independent effects of COX-2 inhibitors and NSAIDs on proatherogenic changes in human monocytes/macrophages. J Investig Med. 2017 Mar;65(3):694-704.
41	Haloperidol inhibits the development of atherosclerotic lesions in LDL receptor knockout mice. Br J Pharmacol. 2015 May;172(9):2397-405.
42	Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1193-7.
43	Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. Tohoku J Exp Med. 2003 Dec;201(4):251-9.
44	17beta-estradiol promotes cholesterol efflux from vascular smooth muscle cells through a liver X receptor -dependent pathway. Int J Mol Med. 2014 Mar;33(3):550-8.
45	Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression. Mol Cell Biochem. 2015 Jan;399(1-2):7-15.
46	PPARalpha agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARalpha/AMPK/AKT/FoxO1 pathway. Acta Pharmacol Sin. 2022 Jan;43(1):167-176.
47	Phospholipase A2 group IIA correlates with circulating high-density lipoprotein cholesterol and modulates cholesterol efflux possibly through regulation of PPAR-gamma/LXR-alpha/ABCA1 in macrophages. J Transl Med. 2021 Nov 27;19(1):484.
48	Effect of Genistein on Cholesterol Metabolism-Related Genes in HepG2 Cell. J Food Sci. 2019 Aug;84(8):2330-2336.
49	FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circ Res. 2010 Mar 5;106(4):720-9.
50	Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317. Neurosci Lett. 2007 Aug 9;423(1):47-52.
51	Multispecies study: low-dose tributyltin impairs ovarian theca cell cholesterol homeostasis through the RXR pathway in five mammalian species including humans. Arch Toxicol. 2019 Jun;93(6):1665-1677.
52	Resveratrol regulates the expression of LXR-alpha in human macrophages. Biochem Biophys Res Commun. 2006 Sep 29;348(3):1047-54.
53	Enhancing PPARgamma by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice. Pharmacol Res. 2020 Oct;160:105059.
54	Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPARgamma-ABCA1 pathway. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10854-60.
55	Liver X Receptors Activation Attenuates Ischemia Reperfusion Injury of Liver Graft in Rats. J Invest Surg. 2019 Jun;32(4):298-303.
56	Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem. 2004 Aug 13;279(33):34674-81.
57	Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. Atherosclerosis. 2007 Mar;191(1):11-21.
58	Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors. Cardiovasc Res. 2006 Dec 1;72(3):473-82.
59	The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. J Immunol. 2007 Mar 1;178(5):3198-207.
60	Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum. 2008 Dec;58(12):3675-83.
61	The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res. 2010 Dec 15;16(24):6060-70.
62	Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87.
63	Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20970-5.
64	Health effects in the Flemish population in relation to low levels of mercury exposure: from organ to transcriptome level. Int J Hyg Environ Health. 2014 Mar;217(2-3):239-47.
65	Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid B. Toxicol Appl Pharmacol. 2014 Nov 15;281(1):78-86.
66	Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux. Chem Res Toxicol. 2014 Oct 20;27(10):1743-56.
67	A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
68	Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291(25):13257-70.
69	Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells. Food Chem Toxicol. 2017 Nov;109(Pt 2):930-940.
70	MicroRNA regulatory networks reflective of polyhexamethylene guanidine phosphate-induced fibrosis in A549 human alveolar adenocarcinoma cells. Toxicol Lett. 2018 May 1;287:49-58.
71	Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells. Reprod Toxicol. 2018 Dec;82:72-79.
72	Transcriptional study after Beauvericin and Enniatin B combined exposure in Jurkat T cells. Food Chem Toxicol. 2019 Aug;130:122-129.
73	Arsenic inhibited cholesterol efflux of THP-1 macrophages via ROS-mediated ABCA1 hypermethylation. Toxicology. 2019 Aug 1;424:152225.
74	Prenatal ethanol exposure-induced a low level of foetal blood cholesterol and its mechanism of IGF1-related placental cholesterol transport dysfunction. Toxicology. 2019 Aug 1;424:152237.
75	System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells. PLoS One. 2019 Aug 22;14(8):e0220894.
76	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
77	Di-n-butyl phthalate promotes lipid accumulation via the miR200c-5p-ABCA1 pathway in THP-1 macrophages. Environ Pollut. 2020 Sep;264:114723.
78	Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicol Appl Pharmacol. 2022 May 1;442:115991.
79	Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. Neuroreport. 2008 Nov 19;19(17):1685-9.
80	Transcriptional profiling of human bronchial epithelial cell BEAS-2B exposed to diesel and biomass ultrafine particles. BMC Genomics. 2018 Apr 27;19(1):302.
81	CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
82	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
83	An induction in hepatic HDL secretion associated with reduced ATPase expression. Am J Pathol. 2009;175(4):1777-87.
84	Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. J Biol Chem. 2005;280(43):35896-903.
85	Transcriptional response to organic compounds from diverse gasoline and biogasoline fuel emissions in human lung cells. Toxicol In Vitro. 2018;48:329-341.
86	2,2',4,4'-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPAR Gamma Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation. Chem Res Toxicol. 2022 Jun 20;35(6):1023-1035.
87	Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes. J Biol Chem. 2007;282(26):18740-9.
88	Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. J Lipid Res. 2004;45(11):2015-24.
89	Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation. J Clin Invest. 2005;115(10):2924-33.
90	LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. Atherosclerosis. 2009;207(1):38-44.
91	Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Mol Neurodegener. 2009 Jan 6;4:1.
92	PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. J Am Soc Nephrol. 2003 Mar;14(3):593-600.
93	Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. Biochem Biophys Res Commun. 2005;334(3):924-9.
94	Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPAR Gamma and adenosine. Eur J Pharmacol. 2013 Jan 5;698(1-3):299-309.
95	Direct effect of 2-palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal-derived astrocytes. FEBS Open Bio. 2023;13(7):1320-1332.
96	Transcriptomics identifies differences between ultrapure non-dioxin-like polychlorinated biphenyls (PCBs) and dioxin-like PCB126 in cultured peripheral blood mononuclear cells. Toxicology. 2011;287(1-3):113-23.
97	Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages. J Biol Chem. 2016;291(21):11172-84.
98	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
99	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
100	Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017;6(11):2646-2659.
101	Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARg/CD36 signal pathway. Toxicol Appl Pharmacol. 2021;431:115733.
102	ABCA1 Is Coordinated with ABCB1 in the Arsenic-Resistance of Human Cells. Appl Biochem Biotechnol. 2019;187(1):365-377.
103	Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells. Toxicol Sci. 2025;203(2):216-226.
104	Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
105	Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol. 2015;28(6):1156-66.
106	Pathway and single gene analyses of inhibited Caco-2 differentiation by ascorbate-stabilized quercetin suggest enhancement of cellular processes associated with development of colon cancer. Mol Nutr Food Res. 2007;51(8):1031-45.
107	Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages. Lipids Health Dis. 2010;9:16.
108	Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS. J Biol Chem. 2016;291(48):25192-25206.
109	Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatin. Biochem Pharmacol. 2004;68(1):155-63.
110	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
111	Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Toxicol Sci. 2013 Oct;135(2):328-46.
112	Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes. Toxicology. 2022;470:153153.
113	Evaluation of Cd-induced cytotoxicity in primary human keratinocytes. Hum Exp Toxicol. 2024;43:9603271231224458.
114	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
115	Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease. J Biol Chem. 2011;286(35):30624-30635.
116	Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells. Diabetes. 2005;54(7):2198-205.
117	Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes. Biochem Pharmacol. 2010;80(9):1450-7.
118	A single infusion of MDCO-216 (ApoA-1 Milano/POPC) increases ABCA1-mediated cholesterol efflux and pre-beta 1 HDL in healthy volunteers and patients with stable coronary artery disease. Eur Heart J Cardiovasc Pharmacother. 2016;2(1):23-9.
119	Resveratrol prevents the impairment of advanced glycosylation end products (AGE) on macrophage lipid homeostasis by suppressing the receptor for AGE via peroxisome proliferator-activated receptor gamma activation. Int J Mol Med. 2010;25(5):729-34.
120	Effects of niacin and chromium on the expression of ATP-binding cassette transporter A1 and apolipoprotein A-1 genes in HepG2 cells. J Nutr Biochem. 2009 Apr;20(4):261-8.
121	Transcriptomic analysis reveals particulate hexavalent chromium regulates key inflammatory pathways in human lung fibroblasts as a possible mechanism of carcinogenesis. Toxicol Appl Pharmacol. 2024;485:116889.
122	[Effects of peroxisome proliferators activated receptors on caveolin-1 expression in foam cells]. Zhonghua Xin Xue Guan Bing Za Zhi. 2007;35(7):661-5.
123	Regulation mechanism of ABCA1 expression by statins in hepatocytes. Eur J Pharmacol. 2011 Jul 15;662(1-3):9-14.
124	Global gene expression analysis reveals a subtle effect of DEHP in human granulosa cell line HGrC1. Reprod Toxicol. 2023;120:108452.
125	Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis. PLoS One. 2014;9(4):e93711.
126	Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the 1 subunit. J Cell Mol Med. 2014;18(2):293-304.
127	Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis. J Toxicol Sci. 2021;46(5):209-222.
128	In vitro screening of understudied PFAS with a focus on lipid metabolism disruption. Arch Toxicol. 2024;98(10):3381-3395.
129	Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not. J Nutr Biochem. 2007;18(6):380-90.
130	Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor Expression. Front Aging Neurosci. 2021;13:634948.
131	Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid- Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease. J Alzheimers Dis. 2015;46(1):109-22.
132	In vitro anti-synovial sarcoma effect of diallyl trisulfide and mRNA profiling. Gene. 2022;816:146172.
133	Exposure to Di-(2-Ethylhexyl) phthalate drives ovarian dysfunction by inducing granulosa cell pyroptosis via the SLC39A5/NF-B/NLRP3 axis. Ecotoxicol Environ Saf. 2023;252:114625.
134	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
135	L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18.
136	Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. Nucleic Acids Res. 2014 Jan;42(2):882-92.
137	Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160.
138	The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells. Mol Cell Endocrinol. 2018;473:124-135.
139	Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023;13(1):10519.
140	A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women. J Lipid Res. 2010;51(3):625-34.
141	DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen. 2012;53(7):542-9.
142	Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure. J Med Chem. 2005;48(17):5419-22.
143	Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes. PLoS One. 2016 Sep 6;11(9):e0162384.
144	Dual roles of nuclear receptor liver X receptor (LXR) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. Biochem Pharmacol. 2013;86(3):428-36.
145	Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages. Molecules. 2015;21(1):E55.
146	Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2. Food Chem Toxicol. 2021;150:112096.
147	Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
148	Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006;118(7):1699-712.
149	Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes. Chem Biol Interact. 2024;392:110946.
150	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
151	Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease. BMC Med Genomics. 2018;11(1):111.
152	miR-20a-5p promotes pulmonary artery smooth muscle cell proliferation and migration by targeting ABCA1. J Biochem Mol Toxicol. 2020;34(12):e22589.
153	Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels. PLoS One. 2013;8(11):e78847.
154	Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization. J Am Coll Cardiol. 2015;66(18):2005-2015.
155	Gene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia. Toxicol Sci. 2016;152(1):155-68.
156	The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29.
157	Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology. 2011;288(1-3):8-17.
158	Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
159	Prothioconazole induces cell cycle arrest by up-regulation of EIF4EBP1 in extravillous trophoblast cells. Arch Toxicol. 2022;96(2):559-570.
160	Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells. Toxicology. 2016;350-352:1-14.
161	PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res. 2007 Feb;48(2):373-84.
162	Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients. Acta Pharmacol Sin. 2008;29(2):252-8.
163	The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model. Toxicol In Vitro. 2022;84:105429.
164	Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. Mol Pharm. 2013;10(8):3242-52.
165	Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015;24(5):1374-89.
166	HMG-CoA reductase inhibitor, simvastatin improves reverse cholesterol transport in type 2 diabetic patients with hyperlipidemia. J Atheroscler Thromb. 2008;15(1):20-5.
167	Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. Chem Res Toxicol. 2014;27(3):377-86.
168	Development of human growth hormone-treated chimeric mice with humanized livers for an evaluation model of drug-induced fatty liver disease. Arch Toxicol. 2025;99(5):2133-2142.
169	Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. J Biol Chem. 2005;280(5):3911-9.
170	Comparison of characteristics of peroxide-conditioned immortal human lens-epithelial cell lines with their murine counterparts. Exp Eye Res. 2004;79(3):411-7.
171	Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma. J Clin Oncol. 2011;29(7):797-804.
172	Conjugated linoleic acid alters global gene expression in human intestinal-like Caco-2 cells in an isomer-specific manner. J Nutr. 2007;137(11):2359-65.
173	Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
174	From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
175	The organotin triphenyltin disrupts cholesterol signaling in mammalian ovarian steroidogenic cells through a combination of LXR and RXR modulation. Toxicol Appl Pharmacol. 2022;453:116209.
176	Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway. Mol Cell Biochem. 2018 Nov;448(1-2):175-185.
177	Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells. J Lipid Res. 2012 May;53(5):941-950.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Exogenous Modulation

Visitor Map

Correspondence