Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00651
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| Drug Name |
Fenofibric acid
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| Synonyms |
2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid; 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic Acid; 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid; 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoic acid; AK117112; BGF9MN2HU1; BRN 2058973; C17H15ClO4; CCRIS 7302; CHEBI:83469; CHEMBL981; EINECS 255-626-9; FNF Acid; LF 153; LF 178 acid; NSC 281318; Procetofenic acid; Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-; Trilipix; UNII-BGF9MN2HU1; W-106287; alpha 1081
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| Drug Type |
Small molecular drug
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| Indication | Hypercholesterolemia [ICD11:5C80.0] | Approved | [1] | |||
| Structure |
|
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| 3D MOL | 2D MOL | |||||
| Formula |
C17H15ClO4
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| Canonical SMILES |
CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
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| InChI |
InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
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| InChIKey |
MQOBSOSZFYZQOK-UHFFFAOYSA-N
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| CAS Number |
CAS 49562-28-9
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| Pharmaceutical Properties | Molecular Weight | 318.7 | Topological Polar Surface Area | 63.6 | ||
| Heavy Atom Count | 22 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
3.9
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| PubChem CID | ||||||
| PubChem SID |
103256438
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,118048388
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,135023245
,135650256
,136990671
,137008576
,139809304
,143270
,143755763
,152028908
,15988368
,162175168
,162263030
,163415486
,164785582
,172913777
,174529345
,175265316
,175611044
,184538157
,187072366
,198991585
,210279847
,210282170
,223352414
,223385806
,223448217
,223519115
,223669964
,29203742
,43121787
,50022223
,50826157
,56312055
,56314036
,58097888
,7671261
,81049613
,8189389
,85171876
,87359585
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| ChEBI ID |
CHEBI:83469
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | ABCA1 | Transporter Info | ATP-binding cassette sub-family A member 1 | Substrate | [2] | |
| References | ||||||
| 1 | Fenofibric acid was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1193-7. | |||||
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