Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0036 Transporter Info | |||||
| Gene Name | ABCA1 | |||||
| Transporter Name | ATP-binding cassette sub-family A member 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Loop building | |||||
| Template PDB | 5XJY_A | Identity | 100% | |||
| Performance | Minimized Score | -1973.407 kcal/mol | ||||
| Ramachandra Favored | Poor |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -1.96 ±0.16 | |||||
| Residues in Favored Region | 2036 | Ramachandran favored | 91.96% | |||
| Number of Outliers | 37 | Ramachandran outliers | 1.67% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.69 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 5XJY | EM | 4.1 Å | Spodoptera frugiperda | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 1-2261 | Mutation | No | |||
| 7ROQ | EM | 4.1 Å | Spodoptera frugiperda | |||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2305 | Mutation | No | |||
| 7TBW | EM | 3.1 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2270 | Mutation | No | |||
| 7TBY | EM | 4 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2270 | Mutation | No | |||
| 7TBZ | EM | 4.3 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2270 | Mutation | No | |||
| 7TC0 | EM | 3.1 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2270 | Mutation | No | |||
| 7TDT | EM | 4 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2270 | Mutation | No | |||
| References | ||||||
| 1 | Structure of the Human Lipid Exporter ABCA1. Cell. 2017 Jun 15;169(7):1228-1239.e10. | |||||
| 2 | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nat Cardiovasc Res. 2022;1(3):238-245. | |||||
| 3 | Activity and Structural Dynamics of Human ABCA1 in a Lipid Membrane. J Mol Biol. 2023;435(8):168038. | |||||
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