Drug Transporter (DT) Information

General Information of DT
DT ID DTD0034
Gene Name SLC18A2
Protein Name Vesicular amine transporter 2
Gene ID
6571
UniProt ID
Q05940
TCDB ID
2.A.1.2.29
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms Monoamine transporter; PKDYS2; SLC18A2; SVAT; SVMT; Solute carrier family 18 member 2; VAT2; VMAT2; Synaptic vesicular amine transporter
DT Family Major Facilitator Superfamily (MFS)
Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family
Function This transporter involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. And it pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.
Disease(s) Neurogenic shock [ICD-11:MG40.Y]
Parkinson's Disease [ICD-11:8A00.0]
Endogenous Substrate(s) Monoamines
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Vesicular amine transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Vesicular amine transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Vesicular amine transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Vesicular amine transporter 2
Microbiota Influence (MBI)

(β) Post-translational Modification of Vesicular amine transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Vesicular amine transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Vesicular amine transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Vesicular amine transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Vesicular amine transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Vesicular amine transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           4 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Dopamine
 Approved Drug Info Parkinson's Disease 8A00.0 [1]
Ergotidine
 Approved Drug Info Migraine 8A80 [2]
Methamphetamine
 Approved Drug Info Attention deficit hyperactivity disorder 6A05 [3]
Norepinephrine
 Approved Drug Info Septic shock 1G41 [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           6 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Choline
305
EM Info Identified using VMAT2-deficient mice [4]
Creatine
586
EM Info Identified using VMAT2-deficient mice [4]
Glutamate
33032
EM Info Identified using VMAT2-deficient mice [4]
Myo-inositol
892
EM Info Identified using VMAT2-deficient mice [4]
Phosphocholine
1014
EM Info Identified using VMAT2-deficient mice [4]
Taurine
1123
EM Info Identified using VMAT2-deficient mice [4]
References
1 SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72.
2 The vesicular monoamine transporter 2: an underexplored pharmacological target. Neurochem Int. 2014 Jul;73:89-97.
3 Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem. 2018 Oct 25;61(20):9121-9131.
4 A metabolomic study of brain tissues from aged mice with low expression of the vesicular monoamine transporter 2 (VMAT2) gene. Neurochem Res. 2008 Feb;33(2):292-300.

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