Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0034 Transporter Info
Gene Name SLC18A2
Transporter Name Vesicular amine transporter 2
Gene ID
6571
UniProt ID
Q05940

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC18A2 gene in glioblastoma multiforme condition [1]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC18A2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Vesicular amine transporter 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NR4A2 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC18A2 gene in brain neuroblastoma condition [2]

TF Protein Name

 Nuclear receptor subfamily 4 group A member 2 Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 Nurr1 KO mice

Detailed Description

 Nuclear receptor subfamily 4 group A member 2 (NR4A2) has been reported to activate the transcription of SLC18A2 gene in brain neuroblastoma condition, which leads to an increased expression of the drug transporter Vesicular amine transporter 2.

       Transcriptional Phenomenon2

 Activation of SLC18A2 gene in health condition [3]

TF Protein Name

 Nuclear receptor subfamily 4 group A member 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 E12.5 mice

Detailed Description

 Nuclear receptor subfamily 4 group A member 2 (NR4A2) has been reported to activate the transcription of SLC18A2 gene in health condition, which leads to an increased expression of the drug transporter Vesicular amine transporter 2.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC18A2 gene in myofibroblasts condition [4]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC18A2 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Vesicular amine transporter 2.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

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       Transcriptional Phenomenon1

 Binding to SLC18A2 gene in megakaryocytes condition [5]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC18A2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Vesicular amine transporter 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC18A2 gene in multiple human cancer types condition [6]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC18A2 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Vesicular amine transporter 2.

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC18A2 gene in ovarian cancer condition [7]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC18A2 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Vesicular amine transporter 2.

        PITX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC18A2 gene in health condition [8]

TF Protein Name

 Pituitary homeobox 3 Transcription Factor Info

Affected Drug/Substrate

 Dopamine

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 Pitx3 KO mice

Detailed Description

 Pituitary homeobox 3 (PITX3) has been reported to activate the transcription of SLC18A2 gene in health condition, which leads to an increased expression of the drug transporter Vesicular amine transporter 2.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

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        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC18A2 gene in colorectal cancer condition [9]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC18A2 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Vesicular amine transporter 2.
References
1 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
2 Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Exp Cell Res. 2003 Aug 15;288(2):324-34.
3 Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Eur J Neurosci. 2003 Oct;18(7):1731-8.
4 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
5 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
6 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
7 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
8 Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. J Neurochem. 2009 Dec;111(5):1202-12.
9 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.

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