| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0477 | ||||
| Gene Name | SLC8A1 | ||||
| Protein Name | Sodium/calcium exchanger 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:3US9_A Identity:87.888% Minimized Score:-743.553 kcal/mol Detail: Structure Info |
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| Synonyms | CNC; NCX1; Na(+)/Ca(2+)-exchange protein 1; SLC8A1; Solute carrier family 8 member 1 | ||||
| DT Family | Ca(2+):Cation Antiporter (CACA) Family ; | ||||
| Tissue Specificity | Detected primarily in heart and at lowerlevels in brain (PubMed:1374913). Expressed in cardiac sarcolemma,brain, kidney, liver, pancreas, skeletal muscle, placenta and lung(PubMed:1476165). | ||||
| Function | This transporter mediates the exchange of one calcium ion and three to four sodium ions on the cell membrane, which is helpful for the regulation of cytoplasmic calcium ion and calcium ion-dependent cellular processes. | ||||
| Endogenous Substrate(s) | Ca2+; Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium/calcium exchanger 1 |
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(β) Cell Distribution Level of Sodium/calcium exchanger 1 |
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(γ) Organelle Distribution Level of Sodium/calcium exchanger 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium/calcium exchanger 1 |
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(γ) Transcriptional Regulation of Sodium/calcium exchanger 1 |
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(δ) Epigenetic Regulation of Sodium/calcium exchanger 1 |
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(ε) Exogenous Modulation of Sodium/calcium exchanger 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium/calcium exchanger 1 |
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(β) Disease-specific Protein Abundances of Sodium/calcium exchanger 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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