Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0477 Transporter Info
Gene Name	SLC8A1
Transporter Name	Sodium/calcium exchanger 1
Gene ID	6546
UniProt ID	P32418

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of SLC8A1 gene		[22]
Regulation Mechanism			Transcription Factor Info
Dietary Constituent
Calcium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcium inhibits the reaction SLC8A1 protein results in increased uptake of Nickel		[32]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC8A1		[1]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen affects the expression of SLC8A1		[2]
Etoposide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Etoposide inhibits the expression of SLC8A1		[3]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC8A1		[4]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC8A1		[5]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC8A1		[6]
Drug in Phase 3 Trial
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC8A1		[17]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the expression of SLC8A1		[13]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC8A1		[15]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC8A1		[9]
Geldanamycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Geldanamycin increases the expression of SLC8A1		[12]
Natural Product
Cinnamic aldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cinnamic aldehyde increases the expression of SLC8A1		[7]
Dust	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dust inhibits the expression of SLC8A1		[11]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC8A1		[16]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLC8A1		[18]
Acute Toxic Substance
Thimerosal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thimerosal increases the expression of SLC8A1		[14]
Carcinogen
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC8A1		[8]
Arsenic	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC8A1 gene		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC8A1 protein		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC8A1 protein		[20]
Regulation Mechanism			Transcription Factor Info
Nickel	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcium inhibits the reaction SLC8A1 protein results in increased uptake of Nickel		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Nickel results in decreased expression of SLC8A1 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SLC8A1 protein results in increased uptake of Nickel		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Sodium promotes the reaction SLC8A1 protein results in increased uptake of Nickel		[32]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde increases the expression of SLC8A1		[10]
Chemical Compound
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC8A1 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in increased expression of SLC8A1 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol co-treated with TGFB1 protein results in increased expression of SLC8A1 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol results in increased expression of SLC8A1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Progesterone inhibits the reaction Estradiol results in increased expression of SLC8A1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC8A1 5' UTR		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLC8A1 promoter		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased expression of SLC8A1 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pentanal increases the expression of SLC8A1		[10]
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)		[19]
Regulation Mechanism			Transcription Factor Info
2-bromopalmitate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC8A1 protein		[20]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC8A1 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC8A1 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC8A1 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in decreased methylation of SLC8A1 intron		[28]
Regulation Mechanism			Transcription Factor Info
Bepridil	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bepridil inhibits the reaction SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)		[19]
Regulation Mechanism			Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC8A1 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A co-treated with Fulvestrant affects the methylation of SLC8A1 gene		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	bisphenol A results in decreased expression of SLC8A1 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	bisphenol A results in increased expression of SLC8A1 protein		[31]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in increased expression of SLC8A1 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC8A1 protein		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC8A1 protein		[20]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC8A1 gene		[33]
Regulation Mechanism			Transcription Factor Info
Chlorodiphenyl (54% Chlorine)	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bepridil inhibits the reaction SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)		[19]
Regulation Mechanism			Transcription Factor Info
cinnamaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cinnamaldehyde results in increased expression of SLC8A1 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC8A1 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC8A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC8A1 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in increased phosphorylation of SLC8A1 protein		[38]
Regulation Mechanism			Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant affects the methylation of SLC8A1 gene		[30]
Regulation Mechanism			Transcription Factor Info
geldanamycin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	geldanamycin results in increased expression of SLC8A1 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Manganese	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
manganese chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in decreased methylation of SLC8A1 intron		[28]
Regulation Mechanism			Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLC8A1 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC8A1 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC8A1 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Ozone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of SLC8A1 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ozone results in increased abundance of Soot metabolite which results in increased expression of SLC8A1 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentanal results in increased expression of SLC8A1 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) results in decreased expression of SLC8A1 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the reaction Estradiol results in increased expression of SLC8A1 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in decreased expression of SLC8A1 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC8A1 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Silicon Dioxide results in decreased expression of SLC8A1 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
Sodium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium promotes the reaction SLC8A1 protein results in increased uptake of Nickel		[32]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC8A1 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
Succimer	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Succimer co-treated with Magnetite Nanoparticles results in increased expression of SLC8A1 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of SLC8A1 mRNA		[9]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC8A1 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vanadates results in increased expression of SLC8A1 mRNA		[43]
Regulation Mechanism			Transcription Factor Info

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Detail Information of Exogenous Modulation

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