Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0477 Transporter Info | |||||
| Gene Name | SLC8A1 | |||||
| Transporter Name | Sodium/calcium exchanger 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 3US9_A | Identity | 87.888% | |||
| Performance | Minimized Score | -743.553 kcal/mol | ||||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | 0.17 ±0.44 | |||||
| Residues in Favored Region | 305 | Ramachandran favored | 95.31% | |||
| Number of Outliers | 5 | Ramachandran outliers | 1.56% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.72 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8JP0 | EM | 3.5 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 937 | Mutation | No | |||
| 8SGI | EM | 2.9 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 982 | Mutation | No | |||
| 8SGJ | EM | 3.1 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 982 | Mutation | No | |||
| 8SGT | EM | 3.6 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 982 | Mutation | No | |||
| References | ||||||
| 1 | Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400. EMBO J. 2024;43(1):14-31. | |||||
| 2 | Structural mechanisms of PIP(2) activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1. bioRxiv. 2025. | |||||
| 3 | Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1. Nat Commun. 2023;14(1):6181. | |||||
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