Drug Transporter (DT) Information

General Information of DT
DT ID DTD0428
Gene Name SLC5A8
Protein Name Sodium-coupled monocarboxylate transporter 1
Gene ID
160728
UniProt ID
Q8N695
TCDB ID
2.A.21.5.3
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms AIT; Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; SLC5A8; SMCT; SMCT1; Sodium iodide-related cotransporter; Solute carrier family 5 member 8
DT Family Solute:Sodium Symporter (SSS) Family ;
Function This transporter catalyzes passive carrier mediated diffusion of iodide and mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. It acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1.
Endogenous Substrate(s) Acetate; Butyrate; Na+; Pyruvate; Lactate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium-coupled monocarboxylate transporter 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium-coupled monocarboxylate transporter 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium-coupled monocarboxylate transporter 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium-coupled monocarboxylate transporter 1
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium-coupled monocarboxylate transporter 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium-coupled monocarboxylate transporter 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium-coupled monocarboxylate transporter 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium-coupled monocarboxylate transporter 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium-coupled monocarboxylate transporter 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium-coupled monocarboxylate transporter 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Gabapentin enacarbil
 Approved Drug Info Postherpetic neuralgia 1E91.5 [1]
References
1 Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507.

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