Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0428 Transporter Info
Gene Name SLC5A8
Transporter Name Sodium-coupled monocarboxylate transporter 1
Gene ID
160728
UniProt ID
Q8N695
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Probenecid results in decreased activity of SLC5A8 protein [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC5A8 exon [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene affects the methylation of SLC5A8 promoter [8]

Regulation Mechanism

 Transcription Factor Info

  4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC5A8 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to SLC5A8 gene [10]

Regulation Mechanism

 Transcription Factor Info

  Cisplatin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin results in decreased susceptibility to Cisplatin which results in increased expression of SLC5A8 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  Decitabine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Decitabine affects the methylation of SLC5A8 gene which affects the expression of SLC5A8 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Fonofos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fonofos results in increased methylation of SLC5A8 promoter [13]

Regulation Mechanism

 Transcription Factor Info

  ICG 001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG 001 results in increased expression of SLC5A8 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  Lactic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC5A8 protein results in increased transport of Lactic Acid co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  Parathion

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Parathion results in increased methylation of SLC5A8 promoter [13]

Regulation Mechanism

 Transcription Factor Info

  Sodium

            7 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC5A8 protein results in increased transport of Butyrates co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 SLC5A8 protein results in increased transport of Carboxylic Acids co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 SLC5A8 protein results in increased transport of Fatty Acids, Volatile co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 SLC5A8 protein results in increased transport of Lactic Acid co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 SLC5A8 protein results in increased transport of Nicotinic Acids co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 SLC5A8 protein results in increased transport of Propionates co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 SLC5A8 protein results in increased transport of Valerates co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

  terbufos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 terbufos results in increased methylation of SLC5A8 promoter [13]

Regulation Mechanism

 Transcription Factor Info

  Valerates

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC5A8 protein results in increased transport of Valerates co-treated with Sodium [1]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Probenecid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Probenecid inhibits the activity of SLC5A8 [1]

  Hydrogen Peroxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Hydrogen Peroxide affects the expression of SLC5A8 [2]

  Ibuprofen

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ibuprofen inhibits the activity of SLC5A8 [3]

  DT Modulation2

 Ibuprofen results in decreased activity of SLC5A8 protein [1]

Regulation Mechanism

 Transcription Factor Info

Patented Pharmaceutical Agent

  ICG-001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG-001 increases the expression of SLC5A8 [6]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution affects the expression of SLC5A8 [7]

  Caffeine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Caffeine results in increased phosphorylation of SLC5A8 protein [9]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Benzo(a)pyrene

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene increases the expression of SLC5A8 [4]

Herbicide

  Atrazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atrazine inhibits the expression of SLC5A8 [5]
References
1 The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. J Physiol. 2004 Jun 15;557(Pt 3):719-31.
2 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352.
3 Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7270-5.
4 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
5 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
6 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
7 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
8 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
9 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
10 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
11 Transcriptomic Landscape of Cisplatin-Resistant Neuroblastoma Cells. Cells. 2019;8(3).
12 Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Cancer Res. 2008;68(12):4494-9.
13 DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen. 2012;53(7):542-9.

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