Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0428 Transporter Info
Gene Name SLC5A8
Transporter Name Sodium-coupled monocarboxylate transporter 1
Gene ID
160728
UniProt ID
Q8N695
Microbiota Influence of This DT (MBI)

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 5 Microbe Influence Related to This Species      

       Microbe Influence1

 Up regulating of SLC30A6 expression in the health condition [1]

Regulating Factor
Butyrate

Studied Phenotype

 Colon cancer [ICD11: 2B90]

In Vitro Model

 colon adenomas cells

Detailed Description

 The host unspecified microbial metabolite butyrate has been reported to upregulate the expression of drug transporter SLC5A8; however, in colon adenomas, this regulatory effect is blocked due to methylation-mediated silencing of the SLC5A8 promoter.

       Microbe Influence2

 Up regulating of SLC5A8 expression in the health condition [2]

Regulating Factor
Chenodeoxycholic acid

Studied Tissue

 Small intestine

In Vitro Model

 Rat small intestine epithelial cells (IEC-6)

Detailed Description

 The metabolite chenodeoxycholic acid generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter SLC5A8.

       Microbe Influence3

 Up regulating of SLC5A8 expression in conventional mice compared with germ-free mice [3]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Ileum/colon

In Vivo Model

 Swiss Webster germ-free mice

Detailed Description

 The host unspecified microbiota has been reported to increase the expression of the drug transporter SLC5A8.

       Microbe Influence4

 Up regulating of SLC5A8 expression in conventional mice compared with germ-free mice [3], [4]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Colon

In Vivo Model

 Swiss Webster germ-free mice

Detailed Description

 The host unspecified microbiota has been reported to increase the expression of the drug transporter SLC5A8.

       Microbe Influence5

 Up regulating of SLC5A8 expression in conventional mice compared with germ-free mice [3], [4]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Ileum

In Vivo Model

 Swiss Webster germ-free mice

Detailed Description

 The host unspecified microbiota has been reported to increase the expression of the drug transporter SLC5A8.
References
1 SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas. PLoS One. 2011;6(6):e20216.
2 Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells. J Cell Biochem. 2012 Sep;113(9):2937-47.
3 Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8. J Gastrointest Surg. 2010 Mar;14(3):449-61.
4 The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharm Sin B. 2021 Jul;11(7):1789-1812.

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