| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0380 | ||||
| Gene Name | SLC4A1 | ||||
| Protein Name | Anion exchange protein 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Crystal Structure Crystallisation Method:X-ray Corresponding Chain:A/B/C/D Sequence Length:1-911 Detail: Struture Info |
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| Synonyms | AE 1; AE1; Band 3 anion transport protein; Anion exchanger 1; BND3; CD233; CHC; DI; EMPB3; EPB3; FR; RTA1A; SAO; SLC4A1; SPH4; SW; Solute carrier family 4 member 1; WD; WD1; WR | ||||
| DT Family | Anion Exchanger (AE) Family ; | ||||
| Tissue Specificity | Detected in erythrocytes (at protein level)(PubMed:7506871, PubMed:26542571). Isoform 2 is expressed inkidney (at protein level) (PubMed:7506871). | ||||
| Function | This transporter functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. | ||||
| Endogenous Substrate(s) | Anions; Phospholipids | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Anion exchange protein 1 |
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(β) Cell Distribution Level of Anion exchange protein 1 |
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(γ) Organelle Distribution Level of Anion exchange protein 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Anion exchange protein 1 |
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(γ) Transcriptional Regulation of Anion exchange protein 1 |
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(δ) Epigenetic Regulation of Anion exchange protein 1 |
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(ε) Exogenous Modulation of Anion exchange protein 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Anion exchange protein 1 |
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(β) Disease-specific Protein Abundances of Anion exchange protein 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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