Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0380 Transporter Info
Gene Name SLC4A1
Transporter Name Anion exchange protein 1
Gene ID
6521
UniProt ID
P02730

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPD 

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       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein delta Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

      Class1.2: Basic helix-loop-helix factors

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        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [1]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene in coronary artery disease [2]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLC4A1 gene in coronary artery disease condition, which affects the expression or function of the drug transporter Anion exchange protein 1.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [1]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        USF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [1]

TF Protein Name

 Upstream stimulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 1 (USF1) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [1]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC4A1 gene in . condition, which leads to a affected expression of the drug transporter Anion exchange protein 1.

        ESR2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [4]

TF Protein Name

 Estrogen receptor beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor beta (ESR2) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [5]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        NR2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC4A1 gene in health condition [6]

TF Protein Name

 Nuclear receptor subfamily 2 group F member 6 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Blood

Related DT Changes

 Up regulating

Experimental Material

 Chicken erythroblasts

Detailed Description

 Nuclear receptor subfamily 2 group F member 6 (NR2F6) has been reported to activate the transcription of SLC4A1 gene in health condition, which leads to an increased expression of the drug transporter Anion exchange protein 1.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene in hematopoiesis condition [7]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC4A1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Anion exchange protein 1.

       Transcriptional Phenomenon2

 Binding to SLC4A1 gene in megakaryocytes condition [8]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC4A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Anion exchange protein 1.

        GATA2 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene in megakaryocytes condition [8]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC4A1 gene in megakaryocytes condition, which leads to a affected expression of the drug transporter Anion exchange protein 1.

       Transcriptional Phenomenon2

 Activation of SLC4A1 gene in hematopoiesis condition [7]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC4A1 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Anion exchange protein 1.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene in erythroleukemia condition [9]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC4A1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Anion exchange protein 1.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC4A1 gene in anemia condition [10]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Studied Phenotype

 Anemia [ICD11: 3A9Z]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 EKLF KO mice

Detailed Description

 Krueppel-like factor 1 (KLF1) has been reported to activate the transcription of SLC4A1 gene in anemia condition, which leads to an increased expression of the drug transporter Anion exchange protein 1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [4]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [4]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [5]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [5]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

TF Superclass3: Helix-turn-helix domains

      Class3.2: Paired box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PAX5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [11]

TF Protein Name

 Paired box protein Pax-5 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Paired box protein Pax-5 (PAX5) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [11]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene in prostate carcinoma condition [12]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC4A1 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Anion exchange protein 1.

      Class3.5: Tryptophan cluster factors

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        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [11]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene in megakaryocytes condition [8]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC4A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Anion exchange protein 1.

       Transcriptional Phenomenon2

 Direct binding to SLC4A1 gene [11]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC4A1 gene [11]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

        SPI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene in HL60 condition [3]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC4A1 gene in HL60 condition, which leads to an affected expression of the drug transporter Anion exchange protein 1.

       Transcriptional Phenomenon2

 Direct binding to SLC4A1 gene [4]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Embryo; Foreskin; Kidney; Lung; Muscle; Placenta; Renal cortex; Renal pelvis; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC4A1 gene, which in turn affects the expression or function of the drug transporter Anion exchange protein 1.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC4A1 gene in megakaryocytes condition [8]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC4A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Anion exchange protein 1.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-131. (ID:ENSG00000004939)
2 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
3 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6 v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (band 3) gene. Cell. 1988 Jan 15;52(1):107-19.
7 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
8 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
9 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
10 Major erythrocyte membrane protein genes in EKLF-deficient mice. Exp Hematol. 2006 Jun;34(6):705-12.
11 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
12 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.

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