General Information of Drug Transporter (DT)
DT ID	DTD0380 Transporter Info
Gene Name	SLC4A1
Protein Name	Anion exchange protein 1
Gene ID	6521
UniProt ID	P02730
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs45545233
Site of GPD	chr17:44260984 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>A / T>C
Minor Allele Frequency	T=0.9040/1789 (Global)
Genotypes CC + CT	Click to Show/Hide the Full List of Affected Drugs:           4 Drugs in Total
Atenolol	N.A.	Alcohol Abuse	Genotypes CC + CT are associated with decreased response to atenolol or metoprolol in people with Hypertension as compared to genotype TT.		[ 1]
Metoprolol	N.A.	Alcohol Abuse	Genotypes CC + CT are associated with decreased response to atenolol or metoprolol in people with Hypertension as compared to genotype TT.		[ 1]
Atenolol	N.A.	Hypertension	Genotypes CC + CT are associated with decreased response to atenolol or metoprolol in people with Hypertension as compared to genotype TT.		[ 1]
Metoprolol	N.A.	Hypertension	Genotypes CC + CT are associated with decreased response to atenolol or metoprolol in people with Hypertension as compared to genotype TT.		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Atenolol	N.A.	Hypertension	Patients with hypertension and the CC genotype may have a decreased response to atenolol or metoprolol, as measured by change in diastolic blood pressure, as compared to patients with the TT genotype. Other genetic. and clinical factors may also affect a patient's response to atenolol or metoprolol.		[ 1]
Metoprolol	N.A.	Hypertension	Patients with hypertension and the CC genotype may have a decreased response to atenolol or metoprolol, as measured by change in diastolic blood pressure, as compared to patients with the TT genotype. Other genetic. and clinical factors may also affect a patient's response to atenolol or metoprolol.		[ 1]
Genotype CT	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Atenolol	N.A.	Hypertension	Patients with hypertension and the CT genotype may have a decreased response to atenolol or metoprolol, as measured by change in diastolic blood pressure, as compared to patients with the TT genotype. Other genetic. and clinical factors may also affect a patient's response to atenolol or metoprolol.		[ 1]
Metoprolol	N.A.	Hypertension	Patients with hypertension and the CT genotype may have a decreased response to atenolol or metoprolol, as measured by change in diastolic blood pressure, as compared to patients with the TT genotype. Other genetic. and clinical factors may also affect a patient's response to atenolol or metoprolol.		[ 1]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Atenolol	N.A.	Hypertension	Patients with hypertension and the TT genotype may have an increased response to atenolol or metoprolol, as measured by change in diastolic blood pressure, as compared to patients with the CC or CT genotypes. Other genetic. and clinical factors may also affect a patient's response to atenolol or metoprolol.		[ 1]
Metoprolol	N.A.	Hypertension	Patients with hypertension and the TT genotype may have an increased response to atenolol or metoprolol, as measured by change in diastolic blood pressure, as compared to patients with the CC or CT genotypes. Other genetic. and clinical factors may also affect a patient's response to atenolol or metoprolol.		[ 1]
References
1	Genomic Association Analysis Reveals Variants Associated With Blood Pressure Response to Beta-Blockers in European Americans. Clin Transl Sci. 2019 Sep;12(5):497-504.

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