Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0380 Transporter Info
Gene Name SLC4A1
Transporter Name Anion exchange protein 1
Gene ID
6521
UniProt ID
P02730
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Furans analog inhibits the reaction Glucose results in increased expression of SLC4A1 protein [5]

Regulation Mechanism

 Transcription Factor Info

  4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid binds to SLC4A1 protein [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  4,4'-dinitro-2,2'-stilbenedisulfonic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4,4'-dinitro-2,2'-stilbenedisulfonic acid inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in increased expression of SLC4A1 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC4A1 exon [10]

Regulation Mechanism

 Transcription Factor Info

  benzo(e)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 benzo(e)pyrene results in increased methylation of SLC4A1 intron [11]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to SLC4A1 gene [12]

Regulation Mechanism

 Transcription Factor Info

  Chlorides

            6 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 4,4'-dinitro-2,2'-stilbenedisulfonic acid inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Dipyridamole inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 Niflumic Acid inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 SLC4A1 protein polymorphism affects the transport of Chlorides [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  Dipyridamole

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dipyridamole inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  Methapyrilene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methapyrilene results in increased methylation of SLC4A1 intron [11]

Regulation Mechanism

 Transcription Factor Info

  Niflumic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Niflumic Acid inhibits the reaction SLC4A1 protein results in increased transport of Chlorides [8]

Regulation Mechanism

 Transcription Factor Info

  pirinixic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 pirinixic acid binds to and results in increased activity of PPARA protein which results in decreased expression of SLC4A1 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  Potassium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC4A1 protein polymorphism affects the transport of Potassium [13]

Regulation Mechanism

 Transcription Factor Info

  Selenious Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC4A1 protein results in increased uptake of Selenious Acid [16]

Regulation Mechanism

 Transcription Factor Info

  Silicon Dioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Silicon Dioxide analog results in decreased expression of SLC4A1 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  Sodium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 SLC4A1 protein polymorphism affects the transport of Sodium [13]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased expression of SLC4A1 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  tert-Butylhydroperoxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 tert-Butylhydroperoxide results in increased degradation of SLC4A1 protein [19]

Regulation Mechanism

 Transcription Factor Info

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid results in increased methylation of SLC4A1 gene [20]

Regulation Mechanism

 Transcription Factor Info

Natural Product

  DT Modulation1

 Resveratrol results in increased activity of CASP3 protein which affects the activity of SLC4A1 protein [15]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Copper Sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Copper Sulfate increases the expression of SLC4A1 [1]

  Tretinoin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tretinoin inhibits the expression of SLC4A1 [2]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen inhibits the expression of SLC4A1 [3]

Drug in Phase 3 Trial

  Resveratrol

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Resveratrol increases the expression of SLC4A1 [4]

Investigative Drug

  Glucose

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Glucose increases the expression of SLC4A1 [5]

Fungicide

  Tebuconazole

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tebuconazole inhibits the expression of SLC4A1 [6]

  tebuconazole

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 tebuconazole results in decreased expression of SLC4A1 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

Health and Environmental Toxicant

  Diethylhexyl Phthalate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Diethylhexyl Phthalate increases the expression of SLC4A1 [7]
References
1 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
2 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
3 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
4 Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy. Tumour Biol. 2014 Jun;35(6):5381-8.
5 Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress. Toxicol Appl Pharmacol. 2017 Nov 1;334:167-179.
6 The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food Chem Toxicol. 2019 Jan;123:481-491.
7 Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPAR Gamma/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
8 Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates. J Biol Chem. 1989;264(33):19607-13.
9 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
10 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
11 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
12 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
13 Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Nat Genet. 2005;37(11):1258-63.
14 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009;4(8):e6796.
15 Resveratrol treatment induces redox stress in red blood cells: a possible role of caspase 3 in metabolism and anion transport. Biol Chem. 2010;391(9):1057-65.
16 Human red blood cell uptake and sequestration of arsenite and selenite: Evidence of seleno-bis(S-glutathionyl) arsinium ion formation in human cells. Biochem Pharmacol. 2020;180:114141.
17 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
18 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
19 Verapamil prevents impairment in filterability of human erythrocytes exposed to oxidative stress. Jpn J Physiol. 2004;54(1):39-46.
20 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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