Drug Transporter (DT) Information

General Information of DT
DT ID DTD0262
Gene Name SLC2A4
Protein Name Glucose transporter type 4, insulin-responsive
Gene ID
6517
UniProt ID
P14672
TCDB ID
2.A.1.1.80
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5EQG_A

Identity:65.253%

Minimized Score:-1345.831 kcal/mol

Detail: Structure Info

Synonyms GLUT-4; GLUT4; SLC2A4; Solute carrier family 2, facilitated glucose transporter member 4
DT Family Major Facilitator Superfamily (MFS)
Sugar Porter (SP) Family
Tissue Specificity Skeletal and cardiac muscles; brown and whitefat.
Function This insulin-regulated transporter facilitates glucose transport.
Endogenous Substrate(s) Glucose
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Glucose transporter type 4, insulin-responsive
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Glucose transporter type 4, insulin-responsive
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Glucose transporter type 4, insulin-responsive
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Glucose transporter type 4, insulin-responsive
Microbiota Influence (MBI)

(β) Post-translational Modification of Glucose transporter type 4, insulin-responsive
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Glucose transporter type 4, insulin-responsive
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Glucose transporter type 4, insulin-responsive
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Glucose transporter type 4, insulin-responsive
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Glucose transporter type 4, insulin-responsive
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Glucose transporter type 4, insulin-responsive
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
2-Deoxyglucose
 Phase 1/2 Drug Info Cancer 2A00-2F9Z [1]
References
1 Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice. Diabetes. 2002 Sep;51(9):2719-26.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.