Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0262 Transporter Info
Gene Name	SLC2A4
Transporter Name	Glucose transporter type 4, insulin-responsive
Gene ID	6517
UniProt ID	P14672

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ATF6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in health condition			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-6 alpha		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	Down regulating
Experimental Material	Rat skeletal muscle cells (L6)
Detailed Description	Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) has been reported to repress the transcription of SLC2A4 gene in health condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in breast cancer bone metastasis condition			[2]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC2A4 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in health condition			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Embryo
Related DT Changes	down regulating
Experimental Material	Mouse differentiated adipocytes (3T3-L1)
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB), influenced by the exogenous polychlorinated dibenzodioxin, has been reported to repress the transcription of SLC2A4 gene in health condition , which leads to a decreased expression of the drug transporter Glucose transporter type 4.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in health condition			[4]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	down regulating
Experimental Material	Rat skeletal muscle cells (L6)
Detailed Description	Transcription factor Jun (JUN), influenced by the exogenous fructose, has been reported to repress the transcription of SLC2A4 gene in health condition , which leads to a decreased expression of the drug transporter Glucose transporter type 4.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
mutated CEBPA (S193D)		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in hepatic dysfunction condition			[6]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Studied Phenotype	Hepatic dysfunction [ICD11: DB9Z]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C/EBPa-S193D KO mice
Detailed Description	mutated CCAAT/enhancer-binding protein alpha (mutated CEBPA (S193D)) has been reported to activate the transcription of SLC2A4 gene in hepatic dysfunction condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
NFE2L2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in health condition			[7]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Affected Drug/Substrate	Insulin
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Embryo
Related DT Changes	down regulating
Experimental Material	Mouse differentiated adipocytes (3T3-L1)
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous arsenic, has been reported to repress the transcription of SLC2A4 gene in health condition , which leads to a decreased expression of the drug transporter Glucose transporter type 4.
phosphorylated CEBPA (p.S193)		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in hepatic dysfunction condition			[6]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Studied Phenotype	Hepatic dysfunction [ICD11: DB9Z]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C/EBPa-S193D KO mice
Detailed Description	phosphorylated CCAAT/enhancer-binding protein alpha (phosphorylated CEBPA (p.S193)) has been reported to activate the transcription of SLC2A4 gene in hepatic dysfunction condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
CLOCK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in cancer condition			[8]
TF Protein Name	Circadian locomoter output cycles protein kaput		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Circadian locomoter output cycles protein kaput (CLOCK) has been reported to activate the transcription of SLC2A4 gene in cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in health condition			[9]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	White adipose tissue
Related DT Changes	Down regulating
Experimental Material	Mouse white adipose tissue preadipocytes cells (3T3-L1)
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to repress the transcription of SLC2A4 gene in health condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
MNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	Max-binding protein MNT		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-binding protein MNT (MNT) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Cervix; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
SREBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in type 2 diabetes condition			[12]
TF Protein Name	Sterol regulatory element-binding protein 1		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	Sprague-Dawley rats
Detailed Description	Sterol regulatory element-binding protein 1 (SREBF1) has been reported to activate the transcription of SLC2A4 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
USF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	Upstream stimulatory factor 2		Transcription Factor Info
Tissue	Cervix; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 2 (USF2) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[14]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	129/SvJ mice
Detailed Description	Estrogen receptor (ESR1) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
ESR2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in health condition			[14]
TF Protein Name	Estrogen receptor beta		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	Down regulating
Experimental Material	129/SvJ mice
Detailed Description	Estrogen receptor beta (ESR2) has been reported to repress the transcription of SLC2A4 gene in health condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
NR1H4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[15]
TF Protein Name	Bile acid receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	Mouse white adipose tissue preadipocytes cells (3T3-L1)
Detailed Description	Bile acid receptor (NR1H4) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
PPARD		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[16]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Heart
Related DT Changes	up regulating
Experimental Material	C57/B6 mice
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD), influenced by the exogenous tamoxifen, has been reported to activate the transcription of SLC2A4 gene in health condition , which leads to an increased expression of the drug transporter Glucose transporter type 4.
Transcriptional Phenomenon2	Repression of SLC2A4 gene in obesity condition			[17]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	Obesity [ICD11: 5B81]
Tissue	Skeletal muscle
Related DT Changes	Down regulating
Experimental Material	Wistar rats
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC2A4 gene in obesity condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
PPARG		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in polycystic ovary syndrome condition			[18]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Polycystic ovary syndrome [ICD11: 5A80.1]
Tissue	Endoderm
Related DT Changes	Up regulating
Experimental Material	human endometria isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of SLC2A4 gene in polycystic ovary syndrome condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
Transcriptional Phenomenon2	Repression of SLC2A4 gene in health condition			[19]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Epididymal fat pad
Related DT Changes	Down regulating
Experimental Material	Rat epididymal fat pads adipocyte isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to repress the transcription of SLC2A4 gene in health condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 12 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
KLF15		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[20]
TF Protein Name	Krueppel-like factor 15		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	Mouse white adipose tissue preadipocytes cells (3T3-L1)
Detailed Description	Krueppel-like factor 15 (KLF15) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in gastric cancer condition			[21]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Affected Drug/Substrate	Metformin
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC2A4 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
SP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	Transcription factor Sp4		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp4 (SP4) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
ZNF143		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	Zinc finger protein 143		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 143 (ZNF143) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
TF Superclass3: Helix-turn-helix domains
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A4 gene in MCF7 condition			[22]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC2A4 gene in MCF7 condition, which leads to an affected expression of the drug transporter Glucose transporter type 4.
E2F4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A4 gene in health condition			[23]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC2A4 gene in health condition, which leads to an affected expression of the drug transporter Glucose transporter type 4.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A4 gene			[24]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC2A4 gene in . condition, which leads to a affected expression of the drug transporter Glucose transporter type 4.
Transcriptional Phenomenon2	Direct binding to SLC2A4 gene			[10]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
FOXO1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[19]
TF Protein Name	Forkhead box protein O1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Epididymal fat pad
Related DT Changes	Up regulating
Experimental Material	Rat epididymal fat pads adipocyte isolates
Detailed Description	Forkhead box protein O1 (FOXO1) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
FOXP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in embryonic stem cell condition			[25]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC2A4 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
Transcriptional Phenomenon2	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
phosphorylated FOXO1 (p.S319)		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in polycystic ovary syndrome condition			[18]
TF Protein Name	Forkhead box protein O1		Transcription Factor Info
Studied Phenotype	Polycystic ovary syndrome [ICD11: 5A80.1]
Tissue	Endoderm
Related DT Changes	Down regulating
Experimental Material	human endometria isolates
Detailed Description	phosphorylated Forkhead box protein O1 (phosphorylated FOXO1 (p.S319)) has been reported to repress the transcription of SLC2A4 gene in polycystic ovary syndrome condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Breast; Liver; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[13]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[11]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
MEF2A		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[26]
TF Protein Name	Myocyte-specific enhancer factor 2A		Transcription Factor Info
Affected Drug/Substrate	Caffeine
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	Up regulating
Experimental Material	Mouse skeletal muscle myoblasts (C2C12)
Detailed Description	Myocyte-specific enhancer factor 2A (MEF2A) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
Transcriptional Phenomenon2	Activation of SLC2A4 gene in health condition			[27]
TF Protein Name	Myocyte-specific enhancer factor 2A		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Myocyte-specific enhancer factor 2A (MEF2A) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
Transcriptional Phenomenon3	Activation of SLC2A4 gene in health condition
TF Protein Name	Myocyte-specific enhancer factor 2A		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Myocyte-specific enhancer factor 2A (MEF2A) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
MEF2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in type 2 diabetes condition			[28]
TF Protein Name	Myocyte-specific enhancer factor 2C		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	Skeletal muscle
Related DT Changes	Up regulating
Experimental Material	Mouse skeletal muscle myoblasts (C2C12)
Detailed Description	Myocyte-specific enhancer factor 2C (MEF2C) has been reported to activate the transcription of SLC2A4 gene in type 2 diabetes condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in skeletal muscle insulin resistance condition			[29]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Studied Phenotype	Skeletal muscle insulin resistance [N.A]
Tissue	Skeletal muscle
Related DT Changes	down regulating
Experimental Material	Sprague-Dawley rats
Detailed Description	Transcription factor p65 (RELA), influenced by the exogenous olanzapine, has been reported to repress the transcription of SLC2A4 gene in skeletal muscle insulin resistance condition , which leads to a decreased expression of the drug transporter Glucose transporter type 4.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC2A4 gene in osteosarcoma condition			[30]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Affected Drug/Substrate	Glucose
Studied Phenotype	Osteosarcoma [ICD11: 2B51]
Tissue	Bone
Related DT Changes	Down regulating
Experimental Material	Human osteosarcoma cells (Saos-2)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC2A4 gene in osteosarcoma condition, which leads to a decreased expression of the drug transporter Glucose transporter type 4.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC2A4 gene in epithelial to mesenchymal transition condition			[31]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC2A4 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Glucose transporter type 4.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[5]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC2A4 gene			[10]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC2A4 gene, which in turn affects the expression or function of the drug transporter Glucose transporter type 4.
TF Superclass10: Yet undefined DNA-binding domains
Class10: Uncharacterized		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[32]
TF Protein Name	Nuclear respiratory factor 1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	Up regulating
Experimental Material	C57BL/6-CBA hybrid mice
Detailed Description	Nuclear respiratory factor 1 (NRF1) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SLC2A4RG		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC2A4 gene in health condition			[33]
TF Protein Name	SLC2A4 regulator		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	SLC2A4 regulator (SLC2A4RG) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.
Transcriptional Phenomenon2	Activation of SLC2A4 gene in health condition			[34]
TF Protein Name	SLC2A4 regulator		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Skeletal muscle
Related DT Changes	Up regulating
Experimental Material	Rats muscle isolates
Detailed Description	SLC2A4 regulator (SLC2A4RG) has been reported to activate the transcription of SLC2A4 gene in health condition, which leads to an increased expression of the drug transporter Glucose transporter type 4.

References
1	Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65.
2	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
3	TCDD suppresses insulin-responsive glucose transporter (GLUT-4) gene expression through C/EBP nuclear transcription factors in 3T3-L1 adipocytes. J Biochem Mol Toxicol. 2006;20(2):79-87.
4	Fructose-induced ROS generation impairs glucose utilization in L6 skeletal muscle cells. Free Radic Res. 2015;49(9):1055-68.
5	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6	Epigenetic changes play critical role in age-associated dysfunctions of the liver. Aging Cell. 2010 Oct;9(5):895-910.
7	Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response. Biochem Biophys Res Commun. 2011 Apr 8;407(2):360-5.
8	Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res. 2010;8(7):952-60.
9	EPAS1 promotes adipose differentiation in 3T3-L1 cells. J Biol Chem. 2004 Sep 24;279(39):40946-53.
10	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-419. (ID:ENSG00000181856)
11	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
12	Regulation of GLUT4 gene expression by SREBP-1c in adipocytes. Biochem J. 2006 Oct 1;399(1):131-9.
13	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
14	Participation of ERalpha and ERbeta in glucose homeostasis in skeletal muscle and white adipose tissue. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E124-33.
15	Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter. Cell Physiol Biochem. 2008;22(1-4):1-14.
16	Peroxisome proliferator-activated receptor beta/delta activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition. Hypertension. 2011 Feb;57(2):223-30.
17	Dissociation between PGC-1alpha and GLUT-4 expression in skeletal muscle of rats fed a high-fat diet. J Nutr Sci Vitaminol (Tokyo). 2009 Dec;55(6):486-91.
18	Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome. Reproduction. 2010 Jul;140(1):123-31.
19	FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity. J Biol Chem. 2006 Jul 21;281(29):19881-91.
20	The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem. 2002 Sep 13;277(37):34322-8.
21	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
22	A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
23	Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
24	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
25	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
26	Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E582-8.
27	Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proc Nutr Soc. 2004;63(2):275-8.
28	Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3820-5.
29	The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats. Life Sci. 2021 Apr 1;270:119037.
30	The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res. 2004 Apr 1;64(7):2627-33.
31	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
32	Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity. FASEB J. 2003 Sep;17(12):1666-73.
33	Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A. Proc Natl Acad Sci U S A. 2003;100(25):14725-30.
34	Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase. Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1071-6.

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