Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0262 Transporter Info
Gene Name	SLC2A4
Transporter Name	Glucose transporter type 4, insulin-responsive
Gene ID	6517
UniProt ID	P14672

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	4-phenylbutyric acid inhibits the reaction Glucosamine results in decreased expression of SLC2A4 mRNA			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-phenylbutyric acid inhibits the reaction Glucosamine results in decreased expression of SLC2A4 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ATF6 mutant form inhibits the reaction Glucosamine results in decreased expression of SLC2A4 mRNA			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ATF6 mutant form inhibits the reaction Glucosamine results in decreased expression of SLC2A4 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ursodoxicoltaurine inhibits the reaction Glucosamine results in decreased expression of SLC2A4 mRNA			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ursodoxicoltaurine inhibits the reaction Glucosamine results in decreased expression of SLC2A4 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bexarotene co-treated with Rosiglitazone results in increased expression of SLC2A4 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with bisphenol AF results in increased expression of SLC2A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone results in increased expression of SLC2A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Rosiglitazone inhibits the reaction PPARG protein co-treated with RXRA protein binds to SLC2A4 promoter			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Rosiglitazone promotes the reaction Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine results in increased expression of SLC2A4 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine results in increased expression of SLC2A4 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dichlorodiphenyl Dichloroethylene promotes the reaction 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with bisphenol AF results in increased expression of SLC2A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone results in increased expression of SLC2A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Rosiglitazone promotes the reaction Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine results in increased expression of SLC2A4 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 protein			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tamoxifen results in increased expression of SLC2A4 mRNA			[10]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Metformin affects the reaction Testosterone results in decreased expression of SLC2A4			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Testosterone co-treated with Calcitriol results in increased expression of SLC2A4 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Testosterone results in increased expression of SLC2A4 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Testosterone co-treated with Calcitriol results in increased expression of SLC2A4 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	CEBPA protein affects the reaction Valproic Acid results in increased expression of SLC2A4 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cyclosporine inhibits the reaction Palmitic Acid results in decreased expression of SLC2A4 protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Palmitic Acid co-treated with Arsenic affects the expression of SLC2A4 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-chloro-5-nitrobenzanilide inhibits the reaction Diethylhexyl Phthalate results in decreased expression of SLC2A4 protein			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ACACB protein affects the reaction Glucose results in decreased expression of SLC2A4 protein			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC2A4 3' UTR			[51]
Regulation Mechanism				Transcription Factor Info
1-Methyl-3-isobutylxanthine	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine results in increased expression of SLC2A4 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dichlorodiphenyl Dichloroethylene promotes the reaction 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with bisphenol AF results in increased expression of SLC2A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone results in increased expression of SLC2A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Rosiglitazone promotes the reaction Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine results in increased expression of SLC2A4 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 protein			[41]
Regulation Mechanism				Transcription Factor Info
2,4,5,2',4',5'-hexachlorobiphenyl	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
2-chloro-5-nitrobenzanilide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-chloro-5-nitrobenzanilide inhibits the reaction Diethylhexyl Phthalate results in decreased expression of SLC2A4 protein			[43]
Regulation Mechanism				Transcription Factor Info
3-methyladenine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-methyladenine promotes the reaction Silybin results in decreased expression of SLC2A4 protein			[44]
Regulation Mechanism				Transcription Factor Info
4-hydroxyisoleucine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-hydroxyisoleucine results in increased expression of SLC2A4 protein			[45]
Regulation Mechanism				Transcription Factor Info
4-phenylbutyric acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-phenylbutyric acid inhibits the reaction Glucosamine results in decreased expression of SLC2A4 mRNA			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-phenylbutyric acid inhibits the reaction Glucosamine results in decreased expression of SLC2A4 protein			[2]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC2A4 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
Adenosine Triphosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC2A4 protein results in increased abundance of Adenosine Triphosphate			[47]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC2A4 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
AZD 1480	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of HK2 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of JAK2 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of PFKM protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of SQSTM1 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased phosphorylation of STAT3 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased phosphorylation of STAT5 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in increased expression of and results in increased lipidation of MAP1LC3B protein			[47]
Regulation Mechanism				Transcription Factor Info
Bexarotene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bexarotene co-treated with Rosiglitazone results in increased expression of SLC2A4 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
bisphenol A	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A promotes the reaction AHR protein binds to SLC2A4 promoter			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A promotes the reaction AHR protein binds to SLC2A4 promoter which results in decreased expression of SLC2A4 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in decreased expression of SLC2A4 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in decreased expression of SLC2A4 protein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	bisphenol A results in increased expression of SLC2A4 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Vitamin D co-treated with bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 protein			[41]
Regulation Mechanism				Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with bisphenol AF results in increased expression of SLC2A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in increased expression of SLC2A4 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC2A4 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
CCG 1423	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CCG 1423 affects the localization of SLC2A4 protein			[56]
Regulation Mechanism				Transcription Factor Info
Citrulline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrulline results in decreased expression of SLC2A4 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC2A4 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the reaction Palmitic Acid results in decreased expression of SLC2A4 protein			[59]
Regulation Mechanism				Transcription Factor Info
Deferoxamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deferoxamine results in decreased expression of SLC2A4 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene promotes the reaction 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein results in increased expression of SLC2A4 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dorsomorphin promotes the reaction Silybin results in decreased expression of SLC2A4 protein			[44]
Regulation Mechanism				Transcription Factor Info
Estrogens	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrogens results in increased expression of SLC2A4 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
Fenbendazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenbendazole analog results in decreased expression of SLC2A4 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fenbendazole results in decreased expression of SLC2A4 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
Hexachlorobenzene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
Ivermectin	15 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of HK2 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of JAK2 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of PFKM protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of SQSTM1 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased phosphorylation of STAT3 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in decreased phosphorylation of STAT5 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	AZD 1480 inhibits the reaction SLC2A4 protein inhibits the reaction Ivermectin results in increased expression of and results in increased lipidation of MAP1LC3B protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Ivermectin results in decreased expression of and affects the localization of SLC2A4 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of HK2 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of JAK2 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of PFKM protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLC2A4 protein inhibits the reaction Ivermectin results in decreased expression of SQSTM1 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	SLC2A4 protein inhibits the reaction Ivermectin results in decreased phosphorylation of STAT3 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	SLC2A4 protein inhibits the reaction Ivermectin results in decreased phosphorylation of STAT5 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	SLC2A4 protein inhibits the reaction Ivermectin results in increased expression of and results in increased lipidation of MAP1LC3B protein			[47]
Regulation Mechanism				Transcription Factor Info
Kynurenine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kynurenine results in decreased expression of SLC2A4 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Kynurenine results in decreased expression of SLC2A4 protein			[53]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in decreased expression of SLC2A4 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
MRK 003	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MRK 003 results in increased expression of SLC2A4 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC2A4 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLC2A4 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
p-coumaric acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p-coumaric acid results in increased expression of SLC2A4 protein			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	procyanidin B1 co-treated with p-coumaric acid results in increased expression of SLC2A4 protein			[35]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
prochloraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	prochloraz results in decreased expression of SLC2A4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
procyanidin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	procyanidin B1 co-treated with p-coumaric acid results in increased expression of SLC2A4 protein			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	procyanidin B1 results in increased expression of SLC2A4 protein			[35]
Regulation Mechanism				Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in increased expression of SLC2A4 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine inhibits the reaction Lipopolysaccharides results in increased expression of SLC2A4 mRNA			[66]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC2A4 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
Silybin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-methyladenine promotes the reaction Silybin results in decreased expression of SLC2A4 protein			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dorsomorphin promotes the reaction Silybin results in decreased expression of SLC2A4 protein			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Silybin results in decreased expression of SLC2A4 protein			[44]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AKT activator SC79 inhibits the reaction sodium arsenite co-treated with INS1 protein affects the localization of SLC2A4 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	HIF1A protein affects the reaction sodium arsenite results in increased expression of and affects the localization of SLC2A4 protein			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	HIF1A protein inhibits the reaction MALAT1 mRNA affects the reaction sodium arsenite results in increased expression of SLC2A4 protein			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	IRS1 protein affects the reaction MIR191 mRNA affects the reaction sodium arsenite co-treated with INS1 protein affects the localization of SLC2A4 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	MALAT1 mRNA affects the reaction sodium arsenite results in increased expression of SLC2A4 protein			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	MIR191 mRNA affects the reaction sodium arsenite co-treated with INS1 protein affects the localization of SLC2A4 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	sodium arsenite co-treated with INS1 protein affects the localization of SLC2A4 protein			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	sodium arsenite results in decreased expression of SLC2A4 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC2A4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	sodium arsenite results in increased expression of and affects the localization of SLC2A4 protein			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	sodium arsenite results in increased expression of SLC2A4 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
Sodium Azide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Azide results in increased expression of SLC2A4 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
STF-31	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	STF-31 inhibits the reaction perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene results in decreased expression of SLC2A4 protein			[42]
Regulation Mechanism				Transcription Factor Info
Sucrose	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oligosaccharides inhibits the reaction Sucrose co-treated with Dietary Fats affects the expression of SLC2A4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Oligosaccharides inhibits the reaction Sucrose co-treated with Dietary Fats affects the expression of SLC2A4 protein			[71]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of SLC2A4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in decreased expression of SLC2A4 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
ursodoxicoltaurine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ursodoxicoltaurine inhibits the reaction Glucosamine results in decreased expression of SLC2A4 mRNA			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ursodoxicoltaurine inhibits the reaction Glucosamine results in decreased expression of SLC2A4 protein			[2]
Regulation Mechanism				Transcription Factor Info
Vanadium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanadium results in decreased expression of SLC2A4 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
warangalone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	warangalone analog results in decreased expression of SLC2A4 protein			[74]
Regulation Mechanism				Transcription Factor Info
Pesticide/Insecticide
DDT	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DDT results in increased expression of SLC2A4 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Dapagliflozin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dapagliflozin inhibits the transportation of 2-Deoxyglucose by SLC2A4			[1]
Affected Drug/Substrate	2-Deoxyglucose	Modulation Type	Inhibition
Olanzapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olanzapine inhibits the expression of SLC2A4			[3]
Regulation Mechanism	via enhancement of Transcription factor p65 (RELA)			Transcription Factor Info
Cell System	Sprague-Dawley rats
Rosiglitazone	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone increases the expression of SLC2A4			[4]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor gamma (PPARG)			Transcription Factor Info
Cell System	Mouse differentiated adipocytes (3T3-L1)
Dexamethasone	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone increases the expression of SLC2A4			[5]
Regulation Mechanism	via enhancement of CCAAT/enhancer-binding protein alpha (CEBPA)			Transcription Factor Info
Cell System	Wistar rat brown adipocytes
Tamoxifen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen increases the expression of SLC2A4			[6]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor delta (PPARD)			Transcription Factor Info
Cell System	C57/B6 mice
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC2A4			[7]
Regulation Mechanism	via enhancement of Estrogen receptor (ESR1)			Transcription Factor Info
Cell System	Mouse differentiated adipocytes (3T3-L1)
Haloperidol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Haloperidol increases the expression of SLC2A4			[8]
Mirtazapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mirtazapine increases the expression of SLC2A4			[8]
Testosterone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the expression of SLC2A4			[9]
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride increases the expression of SLC2A4			[10]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine affects the expression of SLC2A4			[11]
Calcitriol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLC2A4			[12]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC2A4			[13]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC2A4			[14]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC2A4			[15]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC2A4			[16]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC2A4			[17]
Metformin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin increases the expression of SLC2A4			[18]
DT Modulation2	Metformin affects the reaction Testosterone results in decreased expression of SLC2A4			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Metformin inhibits the reaction INS protein results in decreased expression of SLC2A4 protein			[63]
Regulation Mechanism				Transcription Factor Info
Salmeterol Xinafoate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Salmeterol xinafoate inhibits the activity of SLC2A4			[19]
Diazoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazoxide induces the activity of SLC2A4			[20]
Arsenic	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic inhibits the expression of SLC2A4			[21]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Affected Drug/Substrate	Insulin	Modulation Type	Inhibition
Cell System	Mouse differentiated adipocytes (3T3-L1)
Drug Marketed but not Approved by US FDA
Glucosamine	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glucosamine inhibits the expression of SLC2A4			[2]
Regulation Mechanism	via enhancement of Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)			Transcription Factor Info
Cell System	Rat skeletal muscle cells (L6)
Drug in Phase 3 Trial
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC2A4			[31]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC2A4			[29]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC2A4			[28]
Palmitic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid inhibits the expression of SLC2A4			[30]
Drug in Preclinical Test
MRK-003	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MRK-003 increases the expression of SLC2A4			[25]
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC2A4			[27]
Investigative Drug
Glucose	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glucose inhibits the expression of SLC2A4			[34]
P-coumaric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	P-coumaric acid increases the expression of SLC2A4			[35]
Natural Product
Fructose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fructose inhibits the expression of SLC2A4			[23]
Regulation Mechanism	via enhancement of Transcription factor Jun (JUN)			Transcription Factor Info
Cell System	Rat skeletal muscle cells (L6)
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coal Ash increases the expression of SLC2A4			[24]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC2A4			[22]
Regulation Mechanism	via modulation of CCAAT/enhancer-binding protein beta (CEBPB)			Transcription Factor Info
Cell System	Mouse differentiated adipocytes (3T3-L1)
Lead	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lead affects the methylation of SLC2A4 gene			[62]
Regulation Mechanism				Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC2A4			[36]
Carcinogen
DT Modulation1	Arsenic results in decreased expression of SLC2A4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Palmitic Acid co-treated with Arsenic affects the expression of SLC2A4 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC2A4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC2A4			[37]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC2A4 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
Fungicide
Prochloraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prochloraz inhibits the expression of SLC2A4			[32]
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde increases the expression of SLC2A4			[26]
Diethylhexyl Phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate inhibits the expression of SLC2A4			[33]

References
1	Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem. 2008 Mar 13;51(5):1145-9.
2	Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65.
3	The protein kinase D1-mediated inflammatory pathway is involved in olanzapine-induced impairment of skeletal muscle insulin signaling in rats. Life Sci. 2021 Apr 1;270:119037.
4	Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. J Biol Chem. 2015 Mar 6;290(10):6376-86.
5	Insulin and dexamethasone induce GLUT4 gene expression in foetal brown adipocytes: synergistic effect through CCAAT/enhancer-binding protein alpha. Biochem J. 2003 Jun 1;372(Pt 2):617-24.
6	Peroxisome proliferator-activated receptor beta/delta activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition. Hypertension. 2011 Feb;57(2):223-30.
7	Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA. Mol Cell Endocrinol. 2019 Dec 1;498:110447.
8	Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells. J Psychiatr Res. 2006 Jun;40(4):374-9.
9	Effects of testosterone and metformin on glucose metabolism in endometrium. Fertil Steril. 2010 May 1;93(7):2295-8.
10	Oestradiol and SERM treatments influence oestrogen receptor coregulator gene expression in human skeletal muscle cells. Acta Physiol (Oxf). 2009 Nov;197(3):187-96.
11	Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100.
12	Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
13	Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
14	Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
15	Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
16	Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
17	Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPalpha-controlled gene expression. Arch Toxicol. 2020 Oct;94(10):3463-3473.
18	Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome. Eur J Endocrinol. 2008 Jun;158(6):793-801.
19	Prolonged stimulation of 2-adrenergic receptor with 2-agonists impairs insulin actions in H9c2 cells. J Pharmacol Sci. 2018 Nov;138(3):184-191.
20	Diazoxide enhances adipose tissue protein kinase B activation and glucose transporter-4 expression in obese Zucker rats. Med Sci Monit. 2004 Mar;10(3):BR53-60.
21	Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant response. Biochem Biophys Res Commun. 2011 Apr 8;407(2):360-5.
22	TCDD suppresses insulin-responsive glucose transporter (GLUT-4) gene expression through C/EBP nuclear transcription factors in 3T3-L1 adipocytes. J Biochem Mol Toxicol. 2006;20(2):79-87.
23	Fructose-induced ROS generation impairs glucose utilization in L6 skeletal muscle cells. Free Radic Res. 2015;49(9):1055-68.
24	Endothelial effects of emission source particles: acute toxic response gene expression profiles. Toxicol In Vitro. 2009 Feb;23(1):67-77.
25	The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res. 2010 Dec 15;16(24):6060-70.
26	Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
27	CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
28	The lncRNA MALAT1, acting through HIF-1alpha stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells. Biochim Biophys Acta. 2016 Sep;1862(9):1685-95.
29	Bisphenol A and Bisphenol S Induce Distinct Transcriptional Profiles in Differentiating Human Primary Preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
30	Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448.
31	Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
32	Presence of vasculature results in faster insulin response in adipocytes in vascularized adipose tissue model. ALTEX. 2019;36(3):419-434.
33	Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPAR Gamma/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
34	Faster lipid beta-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1alpha in human podocytes. J Biochem Mol Toxicol. 2021 Jul;35(7):e22797.
35	Procyanidin B1 and p-Coumaric Acid from Highland Barley Grain Showed Synergistic Effect on Modulating Glucose Metabolism via IRS-1/PI3K/Akt Pathway. Mol Nutr Food Res. 2021 Sep;65(18):e2100454.
36	Gene expression and cytosine DNA methylation alterations in induced pluripotent stem-cell-derived human hepatocytes treated with low doses of chemical carcinogens. Arch Toxicol. 2019 Nov;93(11):3335-3344.
37	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
38	Exposure to p,p'-DDE enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiation. Toxicol Lett. 2015;238(2):65-71.
39	Subcutaneous abdominal adipose tissue subcompartments: potential role in rosiglitazone effects. Obesity (Silver Spring). 2008;16(9):1983-91.
40	Bisphenol AF promotes inflammation in human white adipocytes. Am J Physiol Cell Physiol. 2020;318(1):C63-C72.
41	Molecular mechanisms of vitamin D plus Bisphenol A effects on adipogenesis in human adipose-derived mesenchymal stem cells. Diabetol Metab Syndr. 2021;13(1):41.
42	A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells. Reprod Toxicol. 2021;104:114-124.
43	Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPAR. Toxicol Appl Pharmacol. 2017;316:17-26.
44	Autophagy and glycolysis independently attenuate silibinin-induced apoptosis in human hepatocarcinoma HepG2 and Hep3B cells. Hum Exp Toxicol. 2021;40(12):2048-2062.
45	4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF- and regulating the expression of insulin signal transduction proteins. Mol Med Rep. 2015;12(5):6555-60.
46	Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
47	Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation. Environ Toxicol. 2022;37(4):754-764.
48	Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
49	Arsenic exposure alters the expression of genes related to metabolic diseases in differentiated adipocytes and in newborns and children. Int J Hyg Environ Health. 2023;250:114124.
50	Combined effects of arsenic and palmitic acid on oxidative stress and lipid metabolism disorder in human hepatoma HepG2 cells. Sci Total Environ. 2021 May 15;769:144849.
51	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
52	Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes. Biochem Biophys Res Commun. 1999;265(1):265-71.
53	Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome. Cell Commun Signal. 2024;22(1):28.
54	Bisphenol A enhances adipogenic signaling pathways in human mesenchymal stem cells. Genes Environ. 2020;42:13.
55	Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes. Toxicology. 2022;470:153153.
56	Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011;121(3):918-29.
57	Citrulline facilitates the glycolysis, proliferation, and metastasis of lung cancer cells by regulating RAB3C. Environ Toxicol. 2024;39(9):4372-4384.
58	Hypoxia increases leptin expression in human PAZ6 adipose cells. Diabetologia. 2002;45(4):527-30.
59	Palmitic acid-induced insulin resistance triggers granulosa cell senescence by disruption of the UPR(mt)/mitophagy/lysosome axis. Chem Biol Interact. 2025;411:111450.
60	Effects of the endocrine-disrupting chemical DDT on self-renewal and differentiation of human mesenchymal stem cells. Environ Health Perspect. 2015;123(1):42-8.
61	Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway. Chem Biol Interact. 2022;361:109983.
62	Blood DNA methylation biomarkers of cumulative lead exposure in adults. J Expo Sci Environ Epidemiol. 2021;31(1):108-116.
63	Chlorogenic acid and caffeic acid from Sonchus oleraceus Linn synergistically attenuate insulin resistance and modulate glucose uptake in HepG2 cells. Food Chem Toxicol. 2019;127:182-187.
64	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
65	Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. J Biol Chem. 2003;278(33):30614-23.
66	The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model. Toxicol In Vitro. 2022;84:105429.
67	High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
68	MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway. Ecotoxicol Environ Saf. 2021;215:112130.
69	Arsenic induces metabolome remodeling in mature human adipocytes. Toxicology. 2023;500:153672.
70	Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?. Am J Physiol Endocrinol Metab. 2008;294(1):E97-102.
71	Anti-diabetic effect of oligosaccharides from seaweed Sargassum confusum via JNK-IRS1/PI3K signalling pathways and regulation of gut microbiota. Food Chem Toxicol. 2019 Sep;131:110562.
72	Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war. Environ Health Perspect. 2006;114(11):1677-83.
73	Dioxin exposure of human CD34+ hemopoietic cells induces gene expression modulation that recapitulates its in vivo clinical and biological effects. Toxicology. 2011;283(1):18-23.
74	Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice. Food Chem Toxicol. 2019;130:1-11.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Exogenous Modulation

Visitor Map

Correspondence