Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0087 Transporter Info
Gene Name	SLC12A6
Transporter Name	Electroneutral potassium-chloride cotransporter 3
Gene ID	9990
UniProt ID	Q9UHW9

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ATF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC12A6 gene in breast cancer bone metastasis condition			[3]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC12A6 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
BATF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Basic leucine zipper transcriptional factor ATF-like		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Brain; Cervix; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in health condition			[6]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC12A6 gene in health condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Transcriptional Phenomenon2	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast; Cervix; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Brain; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC12A6 gene in gastric cancer condition			[7]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC12A6 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 14 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Tissue	Blood; Tonsil
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Tissue	Blood; Colon; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp1 (SP1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
ZNF143		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Zinc finger protein 143		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 143 (ZNF143) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
ZNF76		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Zinc finger protein 76		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 76 (ZNF76) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class2.9: C2CH THAP-type zinc finger factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
THAP11		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	THAP domain-containing protein 11		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	THAP domain-containing protein 11 (THAP11) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
NKX2-1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Homeobox protein Nkx-2.1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
SIX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Homeobox protein SIX5		Transcription Factor Info
Tissue	Blood; Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein SIX5 (SIX5) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in MCF7 cells			[6]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC12A6 gene in MCF7 cells, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Transcriptional Phenomenon2	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
E2F4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in health condition			[8]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC12A6 gene in health condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in health condition			[9]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC12A6 gene in health condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Transcriptional Phenomenon2	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
FOXP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC12A6 gene in health condition			[10]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC12A6 gene in health condition, which leads to a decreased expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Transcriptional Phenomenon2	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
FOXP2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in health condition			[11]
TF Protein Name	Forkhead box protein P2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of SLC12A6 gene in health condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Pancreas; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
ETS2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Protein C-ets-2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-2 (ETS2) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Liver; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
IRF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Interferon regulatory factor 4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 4 (IRF4) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
SPI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in acute myeloid leukemia condition			[12]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC12A6 gene in acute myeloid leukemia condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Transcriptional Phenomenon2	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
NFYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Nuclear transcription factor Y subunit beta		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MEF2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Myocyte-specific enhancer factor 2A		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class5.3: SAND domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GMEB2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[1]
TF Protein Name	Glucocorticoid modulatory element-binding protein 2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Glucocorticoid modulatory element-binding protein 2 (GMEB2) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TF Superclass6: Immunoglobulin fold
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in epithelial to mesenchymal transition condition			[13]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC12A6 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in megakaryocytes condition			[14]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC12A6 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class6.5: T-Box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EOMES		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC12A6 gene in health condition			[15]
TF Protein Name	Eomesodermin homolog		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Eomesodermin homolog (EOMES) has been reported to activate the transcription of SLC12A6 gene in health condition, which leads to an increased expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[5]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[4]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Blood; Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC12A6 gene in epithelial ovarian cancer condition			[16]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC12A6 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Electroneutral potassium-chloride cotransporter 3.
TF Superclass8: beta-Sheet binding to DNA
Class8.1: TATA-binding proteins		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TBP		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC12A6 gene			[2]
TF Protein Name	TATA-box-binding protein		Transcription Factor Info
Tissue	Bone marrow; Cervix; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	TATA-box-binding protein (TBP) can directly bind to the SLC12A6 gene, which in turn affects the expression or function of the drug transporter Electroneutral potassium-chloride cotransporter 3.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-294. (ID:ENSG00000140199)
3	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
4	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
6	A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
7	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
8	Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
9	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
10	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
11	Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.
12	Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
13	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
14	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
15	Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25(3):238-50.
16	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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