Drug Transporter (DT) Information

General Information of DT
DT ID DTD0087
Gene Name SLC12A6
Protein Name Electroneutral potassium-chloride cotransporter 3
Gene ID
9990
UniProt ID
Q9UHW9
TCDB ID
2.A.30.1.15
3D Structure

Modelled DT Structure

Method:loop building

Template PDB:6M22_A

Identity:98.521%

Minimized Score:-2381.646 kcal/mol

Detail: Structure Info

Synonyms ACCPN; K-Cl cotransporter 3; KCC3; KCC3A; KCC3B; SLC12A6; Solute carrier family 12 member 6
DT Family Cation-Chloride Cotransporter (CCC) Family ;
Tissue Specificity Highly expressed in heart, brain and kidney.Detected at lower levels in skeletal muscle, placenta, lung andpancreas. Detected in umbilical vein endothelial cells. Isoform 2is more abundant in kidney. Isoform 5 is testis specific.Expressed in the proximal tubule of the kidney (at protein level).
Function This transporter medially conducts neutral potassium chloride co-transport.
Endogenous Substrate(s) Potassium; Chloride
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Electroneutral potassium-chloride cotransporter 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Electroneutral potassium-chloride cotransporter 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Electroneutral potassium-chloride cotransporter 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Electroneutral potassium-chloride cotransporter 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Electroneutral potassium-chloride cotransporter 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Electroneutral potassium-chloride cotransporter 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Electroneutral potassium-chloride cotransporter 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Electroneutral potassium-chloride cotransporter 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Electroneutral potassium-chloride cotransporter 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Potassium chloride
 Approved Drug Info Hypokalemia 5C77 [1]
References
1 Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site. Neuropsychopharmacology. 2009 Jan;34(2):458-67.

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