Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0036 Transporter Info
Gene Name	ABCA1
Transporter Name	ATP-binding cassette sub-family A member 1
Gene ID	19
UniProt ID	O95477

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in breast cancer bone metastasis condition			[1]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of ABCA1 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCA1 gene in leukemia condition			[3]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Down regulating
Experimental Material	Mouse leukemia cells (RAW 264.7)
Detailed Description	Fos-related antigen 2 (FOSL2) has been reported to repress the transcription of ABCA1 gene in leukemia condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 1.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in tangier disease condition			[4]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Tangier disease [ICD11: 5C81.0]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Transcription factor Jun (JUN) has been reported to activate the transcription of ABCA1 gene in tangier disease condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[5]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[6]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
CLOCK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA1 gene in cancer condition			[7]
TF Protein Name	Circadian locomoter output cycles protein kaput		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Circadian locomoter output cycles protein kaput (CLOCK) has been reported to bind to the transcription of ABCA1 gene in cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[8]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Brain; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
NCOA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in health condition			[9]
TF Protein Name	Nuclear receptor coactivator 1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Human kidney human embryonic kidney 293T cells (HEK 293T)
Detailed Description	Nuclear receptor coactivator 1 (NCOA1) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
SREBF2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in health condition			[10]
TF Protein Name	Sterol regulatory element-binding protein 2		Transcription Factor Info
Affected Drug/Substrate	Mevastatin
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Ovary
Related DT Changes	Up regulating
Experimental Material	Chinese hamster ovary epithelial cells (CHO)
Detailed Description	Sterol regulatory element-binding protein 2 (SREBF2) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Repression of ABCA1 gene in health condition
TF Protein Name	Sterol regulatory element-binding protein 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Sterol regulatory element-binding protein 2 (SREBF2) has been reported to repress the transcription of ABCA1 gene in health condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 1.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[2]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in leukemia condition			[3]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW 264.7)
Detailed Description	Upstream stimulatory factor 1 (USF1) has been reported to activate the transcription of ABCA1 gene in leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
USF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in leukemia condition			[3]
TF Protein Name	Upstream stimulatory factor 2		Transcription Factor Info
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW 264.7)
Detailed Description	Upstream stimulatory factor 2 (USF2) has been reported to activate the transcription of ABCA1 gene in leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[5]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 16 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA1 gene in prostate cancer condition			[11]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of ABCA1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Binding to ABCA1 gene in prostate cancer condition			[12]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of ABCA1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon3	Activation of ABCA1 gene in castration-resistant prostate cancers condition			[13]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of ABCA1 gene in castration-resistant prostate cancers condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene in breast cancer condition			[14]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Estrogen receptor (ESR1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
ESR2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in health condition			[15]
TF Protein Name	Estrogen receptor beta		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Blood
Related DT Changes	up regulating
Experimental Material	C57BL/6 mice vascular smooth muscle cells
Detailed Description	Estrogen receptor beta (ESR2), influenced by the exogenous estradiol, has been reported to activate the transcription of ABCA1 gene in health condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA1 gene			[16]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCA1 gene in . condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
NR1H2		Click to Show/Hide to Show 5 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in health condition			[17]
TF Protein Name	Oxysterols receptor LXR-beta		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Oxysterols receptor LXR-beta (NR1H2) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in hypocholesterolemia condition			[18]
TF Protein Name	Oxysterols receptor LXR-beta		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Hypocholesterolemia [ICD11: 5C81]
Tissue	Duodenum
Related DT Changes	Up regulating
Experimental Material	A129 mice
Detailed Description	Oxysterols receptor LXR-beta (NR1H2) has been reported to activate the transcription of ABCA1 gene in hypocholesterolemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon3	Activation of ABCA1 gene in acute monocytic leukemia condition			[19]
TF Protein Name	Oxysterols receptor LXR-beta		Transcription Factor Info
Studied Phenotype	Acute monocytic leukemia [ICD11: 2A60.34]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Human childhood acute monocytic leukemia cells (THP-1)
Detailed Description	Oxysterols receptor LXR-beta (NR1H2) has been reported to activate the transcription of ABCA1 gene in acute monocytic leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon4	Activation of ABCA1 gene in atherosclerosis condition			[20]
TF Protein Name	Oxysterols receptor LXR-beta		Transcription Factor Info
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW 264.7)
Detailed Description	Oxysterols receptor LXR-beta (NR1H2) has been reported to activate the transcription of ABCA1 gene in atherosclerosis condition, which leads to an enhanced function of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon5	Activation of ABCA1 gene in insulinoma condition			[21]
TF Protein Name	Oxysterols receptor LXR-beta		Transcription Factor Info
Studied Phenotype	Insulinoma [ICD11: 2C10.1]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	C57BL/129OlaHsd mice
Detailed Description	Oxysterols receptor LXR-beta (NR1H2) has been reported to activate the transcription of ABCA1 gene in insulinoma condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
NR1H3		Click to Show/Hide to Show 12 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in hypocholesterolemia condition			[18]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Hypocholesterolemia [ICD11: 5C81]
Tissue	Duodenum
Related DT Changes	Up regulating
Experimental Material	A129 mice
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in hypocholesterolemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in health condition			[22]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Porcine brain capillary endothelial cell isolates
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon3	Activation of ABCA1 gene in leukemia condition			[23]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon4	Activation of ABCA1 gene in atherosclerosis condition			[24]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon5	Activation of ABCA1 gene in hepatoblastoma condition			[25]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	human hepatocytes (HepG2)
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3), influenced by the exogenous arsenic trioxide, has been reported to activate the transcription of ABCA1 gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon6	Activation of ABCA1 gene in atherosclerotic condition			[26]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Affected Drug/Substrate	T0901317
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in atherosclerotic condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon7	Activation of ABCA1 gene in health condition
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon8	Activation of ABCA1 gene in obesity condition			[27]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Obesity [ICD11: 5B81]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in obesity condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon9	Activation of ABCA1 gene in acute monocytic leukemia condition			[19]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Acute monocytic leukemia [ICD11: 2A60.34]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Human childhood acute monocytic leukemia cells (THP-1)
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in acute monocytic leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon10	Activation of ABCA1 gene in hepatocellular carcinoma condition			[28]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human adult hepatocellular carcinoma cells (Huh7)
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA1 gene in hepatocellular carcinoma condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon11	Activation of ABCA1 gene in ischemia-reperfusion injury condition			[29]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Ischemia-reperfusion injury [DB98.B]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Sprague-Dawley liver isolates
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3), influenced by the exogenous arsenic trioxide, has been reported to activate the transcription of ABCA1 gene in ischemia-reperfusion injury condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon12	Repression of ABCA1 gene in hepatoblastoma condition			[30]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3), influenced by the exogenous arsenic trioxide, has been reported to repress the transcription of ABCA1 gene in hepatoblastoma condition , which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 1.
NR1H4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in hypocholesterolemia condition			[18]
TF Protein Name	Bile acid receptor		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Hypocholesterolemia [ICD11: 5C81]
Tissue	Duodenum
Related DT Changes	Up regulating
Experimental Material	A129 mice
Detailed Description	Bile acid receptor (NR1H4) has been reported to activate the transcription of ABCA1 gene in hypocholesterolemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
NR1I2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in health condition			[31]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Wistar rats
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
NR3C1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCA1 gene in health condition			[32]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Blood
Related DT Changes	Down regulating
Experimental Material	human monocyte-derived macrophage isolates
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to repress the transcription of ABCA1 gene in health condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 1.
PPARA		Click to Show/Hide to Show 7 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in hyperlipidemia condition			[33]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Hyperlipidemia [ICD11: 5C80]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	human hyperlipidemia blood cell isolates
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of ABCA1 gene in hyperlipidemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in health condition			[22]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Porcine brain capillary endothelial cell isolates
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon3	Activation of ABCA1 gene in hyperlipidemia condition			[34]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Affected Drug/Substrate	Fenofibrate
Studied Phenotype	Hyperlipidemia [ICD11: 5C80]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	human hyperlipidemia blood cell isolates
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of ABCA1 gene in hyperlipidemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon4	Activation of ABCA1 gene in non-small cell lung cancer condition			[35]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Affected Drug/Substrate	Gefitinib
Studied Phenotype	Non-small cell lung cancer [ICD11: 2C25.Y]
Tissue	Lung
Related DT Changes	up regulating
Experimental Material	Human non-small cell lung cancer cells (H1975
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA), influenced by the exogenous fenofibrate, has been reported to activate the transcription of ABCA1 gene in non-small cell lung cancer condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon5	Activation of ABCA1 gene in acute monocytic leukemia condition			[19]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Acute monocytic leukemia [ICD11: 2A60.34]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Human childhood acute monocytic leukemia cells (THP-1)
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of ABCA1 gene in acute monocytic leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon6	Activation of ABCA1 gene in hepatoblastoma condition			[36]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA), influenced by the exogenous fenofibrate, has been reported to activate the transcription of ABCA1 gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon7	Activation of ABCA1 gene in hepatoma condition			[37]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Hepatoma [2E92.7]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	rat hepatoma cells (McARH7777)
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA), influenced by the exogenous fenofibrate, has been reported to activate the transcription of ABCA1 gene in hepatoma condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
PPARD		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in myofibroblast condition			[38]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of ABCA1 gene in myofibroblast condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in acute monocytic leukemia condition			[19]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	Acute monocytic leukemia [ICD11: 2A60.34]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Human childhood acute monocytic leukemia cells (THP-1)
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of ABCA1 gene in acute monocytic leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
PPARG		Click to Show/Hide to Show 8 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in hyperlipidemia condition			[33]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Hyperlipidemia [ICD11: 5C80]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	human hyperlipidemia blood cell isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCA1 gene in hyperlipidemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in health condition			[22]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Porcine brain capillary endothelial cell isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon3	Activation of ABCA1 gene in leukemia condition			[23]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCA1 gene in leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon4	Activation of ABCA1 gene in atherosclerosis condition			[24]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCA1 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon5	Activation of ABCA1 gene in acute monocytic leukemia condition			[19]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Acute monocytic leukemia [ICD11: 2A60.34]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Human childhood acute monocytic leukemia cells (THP-1)
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCA1 gene in acute monocytic leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon6	Activation of ABCA1 gene in coronary artery disease condition			[39]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Coronary artery disease [BA8Y]
Tissue	Blood
Related DT Changes	up regulating
Experimental Material	Human coronary artery disease plasma sample
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous quercetin, has been reported to activate the transcription of ABCA1 gene in coronary artery disease condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon7	Activation of ABCA1 gene in acute monocytic leukemia condition			[40]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Acute monocytic leukemia [ICD11: 2A60.34]
Tissue	Blood
Related DT Changes	up regulating
Experimental Material	Human childhood acute monocytic leukemia cells (THP-1)
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous quercetin, has been reported to activate the transcription of ABCA1 gene in acute monocytic leukemia condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon8	Activation of ABCA1 gene in type 2 diabetes condition			[41]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Type 2 diabetes [ICD11: 5A11]
Tissue	White adipose tissue
Related DT Changes	up regulating
Experimental Material	Human type 2 diabetes adipose stem cell-derived adipocytes
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous quercetin, has been reported to activate the transcription of ABCA1 gene in type 2 diabetes condition , which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
RARA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in health condition			[42]
TF Protein Name	Retinoic acid receptor alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Retinoic acid receptor alpha (RARA) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
RARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in health condition			[42]
TF Protein Name	Retinoic acid receptor gamma		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	C57BL/6J mice
Detailed Description	Retinoic acid receptor gamma (RARG) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
RXRA		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in leukemia condition			[23]
TF Protein Name	Retinoic acid receptor RXR-alpha		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Leukemia [ICD11: 2A20-2B3Z]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Retinoic acid receptor RXR-alpha (RXRA) has been reported to activate the transcription of ABCA1 gene in leukemia condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in health condition			[43]
TF Protein Name	Retinoic acid receptor RXR-alpha		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Human kidney human embryonic kidney 293T cells (HEK 293T)
Detailed Description	Retinoic acid receptor RXR-alpha (RXRA) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
VDR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA1 gene in THP-1 human monocytic leukemia cells condition			[44]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of ABCA1 gene in THP-1 human monocytic leukemia cells condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[6]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 11 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[6]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Tissue	Tonsil
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma 6 protein (BCL6) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[8]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[5]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[8]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
SNAI2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[5]
TF Protein Name	Zinc finger protein SNAI2		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein SNAI2 (SNAI2) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
SP1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in tangier disease condition			[4]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Tangier disease [ICD11: 5C81.0]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of ABCA1 gene in tangier disease condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in health condition
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon3	Activation of ABCA1 gene in health condition			[43]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Human kidney human embryonic kidney 293T cells (HEK 293T)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
SP3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in tangier disease condition			[4]
TF Protein Name	Transcription factor Sp3		Transcription Factor Info
Affected Drug/Substrate	Cholesterol
Studied Phenotype	Tangier disease [ICD11: 5C81.0]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	Mouse leukemia cells (RAW264)
Detailed Description	Transcription factor Sp3 (SP3) has been reported to activate the transcription of ABCA1 gene in tangier disease condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
SP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[2]
TF Protein Name	Transcription factor Sp4		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp4 (SP4) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
ZNF202		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCA1 gene in hepatoblastoma condition			[45]
TF Protein Name	Zinc finger protein 202		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Zinc finger protein 202 (ZNF202) has been reported to repress the transcription of ABCA1 gene in hepatoblastoma condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 1.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA1 gene in breast cancer condition			[46]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of ABCA1 gene in breast cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
PBX1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in ovarian cancer condition			[47]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of ABCA1 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Direct binding to ABCA1 gene			[8]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[5]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[6]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[8]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[8]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[16]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ABCA1 gene in . condition, which leads to a affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Repression of ABCA1 gene in hepatoblastoma condition			[48]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to repress the transcription of ABCA1 gene in hepatoblastoma condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 1.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in breast cancer condition			[49]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of ABCA1 gene in breast cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[2]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
FOXP2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[50]
TF Protein Name	Forkhead box protein P2		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of ABCA1 gene in . condition, which leads to a affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[5]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[5]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[2]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[6]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCA1 gene			[6]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the ABCA1 gene, which in turn affects the expression or function of the drug transporter ATP-binding cassette sub-family A member 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFKB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCA1 gene in acute monocytic leukemia condition			[51]
TF Protein Name	Nuclear factor NF-kappa-B p105 subunit		Transcription Factor Info
Studied Phenotype	Acute monocytic leukemia [ICD11: 2A60.34]
Tissue	Blood
Related DT Changes	Down regulating
Experimental Material	Human childhood acute monocytic leukemia cells (THP-1)
Detailed Description	Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to repress the transcription of ABCA1 gene in acute monocytic leukemia condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 1.
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in fibrosarcoma condition			[52]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor p65 (RELA) has been reported to activate the transcription of ABCA1 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA1 gene in glioblastoma multiforme condition			[53]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of ABCA1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
Transcriptional Phenomenon2	Activation of ABCA1 gene in health condition			[54]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of ABCA1 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA1 gene in health condition			[55]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCA1 gene in health condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA1 gene in prostate cancer condition			[56]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ABCA1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 1.

References
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2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene. J Lipid Res. 2002 Feb;43(2):297-306.
4	Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7987-92.
5	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-372. (ID:ENSG00000165029)
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