| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0528 | ||||
| Gene Name | SCN8A | ||||
| Protein Name | Voltage-gated sodium channel alpha Nav1.6 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6J8E_A Identity:75.025% Minimized Score:-3266.391 kcal/mol Detail: Structure Info |
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| Synonyms | BFIS5; CERIII; CIAT; EIEE13; MED; MYOCL2; NaCh6; Nav1.6; PN4; SCN8A; Sodium channel protein type VIII subunit alpha; Sodium channel protein type 8 subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Isoform 5 is expressed in non-neuronaltissues, such as monocytes/macrophages. | ||||
| Function | This transporter mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated sodium channel alpha Nav1.6 |
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(β) Cell Distribution Level of Voltage-gated sodium channel alpha Nav1.6 |
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(γ) Organelle Distribution Level of Voltage-gated sodium channel alpha Nav1.6 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-gated sodium channel alpha Nav1.6 |
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(γ) Transcriptional Regulation of Voltage-gated sodium channel alpha Nav1.6 |
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(δ) Epigenetic Regulation of Voltage-gated sodium channel alpha Nav1.6 |
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(ε) Exogenous Modulation of Voltage-gated sodium channel alpha Nav1.6 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated sodium channel alpha Nav1.6 |
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(β) Disease-specific Protein Abundances of Voltage-gated sodium channel alpha Nav1.6 |
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(γ) Species- and Tissue-specific DT Abundances |
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