General Information of Drug Transporter (DT)
DT ID	DTD0528 Transporter Info
Gene Name	SCN8A
Transporter Name	Voltage-gated sodium channel alpha Nav1.6
Gene ID	6334
UniProt ID	O95788
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6J8E_A		Identity	75.025%
Performance	Minimized Score	-3266.391 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	Medium
Ramachandran Plot
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	Ramz Z Score	-1.13 ±0.17
	Residues in Favored Region	1895	Ramachandran favored	95.85%
	Number of Outliers	15	Ramachandran outliers	0.76%
Local Quality
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	QMEANBrane Score		0.74
AlphaFold Protein Structure Database	O95788 Click to jump to the details page
SWISS-MODEL Database	O95788 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8FHD	EM	3.1 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	1-1980		Mutation	No
8GZ1	EM	3.4 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	B
Sequence Length	1-1980		Mutation	No
8GZ2	EM	3.3 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	B
Sequence Length	1-1980		Mutation	No
References
1	Cryo-EM structure of human voltage-gated sodium channel Na(v)1.6. Proc Natl Acad Sci U S A. 2023;120(5):e2220578120.
2	Structure of human Na(V)1.6 channel reveals Na(+) selectivity and pore blockade by 4,9-anhydro-tetrodotoxin. Nat Commun. 2023;14(1):1030.

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