Detail Information of Inter-species Structural Difference

General Information of Drug Transporter (DT)
DT ID DTD0528 Transporter Info
Gene Name SCN8A
Protein Name Voltage-gated sodium channel alpha Nav1.6
Gene ID
6334
UniProt ID
O95788
3D Structure

Modelled Stucture

Method:Homology modeling

Teplate PDB:6J8E_A

Identity:75.025%

Minimized Score:-3266.391

Detail: Structure Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Scn8a
        UniProt ID
Q9WTU3
        UniProt Entry
SCN8A_MOUSE
        3D Structure

Crystallisation Method:X-ray

Expression System:Escherichia coli

PDB ID:3WFN

Corresponding Chain:B/C/D/E

Sequence Length:1893-1914
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Rattus norvegicus (Rat)
        Gene Name Scn8a
        UniProt ID
O88420
        UniProt Entry
SCN8A_RAT
        3D Structure

Method:Homology modeling

Teplate PDB:6J8E_A

Sequence Length:1977

Identity:74.445%

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        Performance Minimized Score -3192.031 kcal/mol
Ramachandra Favored

Medium
QMEANBrane Quality

Medium
        Ramachandran Plot

Ramz Z Score:-1.34 ±0.17

Residues in Favored Region:1887

Ramachandran favored:95.54%

Number of Outliers:25

Ramachandran outliers:1.27%
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        Local Quality

QMEANBrane Score:0.73
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