| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0518 | ||||
| Gene Name | CACNA1A | ||||
| Protein Name | Voltage-gated calcium channel alpha Cav2.1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6JPA_A Identity:49.337% Minimized Score:-1477.492 kcal/mol Detail: Structure Info |
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| Synonyms | APCA; BI; Brain calcium channel I; CACH4; CACN3; CACNA1A; CACNL1A4; CAV2.1; Calcium channel, L type, alpha-1 polypeptide isoform 4; EA2; EIEE42; FHM; HPCA; MHP; MHP1; SCA6; Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-gated calcium channel subunit alpha Cav2.1 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Brain specific; mainly found in cerebellum,cerebral cortex, thalamus and hypothalamus. Expressed in the smallcell lung carcinoma cell line SCC-9. No expression in heart,kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current incerebellar granule cells. | ||||
| Function | This voltage-sensitive transporter mediates the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282). They are however insensitive to dihydropyridines (DHP). | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated calcium channel alpha Cav2.1 |
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(β) Cell Distribution Level of Voltage-gated calcium channel alpha Cav2.1 |
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(γ) Organelle Distribution Level of Voltage-gated calcium channel alpha Cav2.1 |
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Regulatory Variability Data of This DT |
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(α) Microbiota Influence of Voltage-gated calcium channel alpha Cav2.1 |
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(β) Post-translational Modification of Voltage-gated calcium channel alpha Cav2.1 |
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(γ) Transcriptional Regulation of Voltage-gated calcium channel alpha Cav2.1 |
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(δ) Epigenetic Regulation of Voltage-gated calcium channel alpha Cav2.1 |
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(ε) Exogenous Modulation of Voltage-gated calcium channel alpha Cav2.1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated calcium channel alpha Cav2.1 |
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(β) Disease-specific Protein Abundances of Voltage-gated calcium channel alpha Cav2.1 |
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(γ) Species- and Tissue-specific DT Abundances |
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