Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0518 Transporter Info
Gene Name CACNA1A
Transporter Name Voltage-gated calcium channel alpha Cav2.1
Gene ID
773
UniProt ID
O00555

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ATF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-1 Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        ATF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [2]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-2 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [3]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Bone marrow; Breast; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [4]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Colon; Coronary artery; Liver; Lung; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [4]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        EPAS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1A gene in health condition [5]

TF Protein Name

 Endothelial PAS domain-containing protein 1 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Pancreas

Related DT Changes

 Up regulating

Experimental Material

 Human pancreas cells (SB AD3.1)

Detailed Description

 Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of CACNA1A gene in health condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [1]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in glioblastoma multiforme condition [6]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of CACNA1A gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in prostate cancer condition [7]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of CACNA1A gene in prostate cancer condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in hematopoiesis condition [8]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of CACNA1A gene in hematopoiesis condition, which leads to a affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        GATA3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [3]

TF Protein Name

 Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Tissue

 Blood; Brain; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        BCL11A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [1]

TF Protein Name

 B-cell lymphoma/leukemia 11A Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 B-cell lymphoma/leukemia 11A (BCL11A) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in erythroleukemia condition [9]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of CACNA1A gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [2]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [4]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1A gene in podocyte condition [10]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of CACNA1A gene in podocyte condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [3]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        HNF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1A gene in maturity onset diabetes of [11]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Maturity onset diabetes of the young [ICD11: 5A13.6]

Tissue

 Pancreas

Related DT Changes

 Up regulating

Experimental Material

 human islet b-cell isolates

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of CACNA1A gene in maturity onset diabetes of the young condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in health condition [12]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of CACNA1A gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNA1A gene in ovarian cancer condition [13]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of CACNA1A gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

      Class3.2: Paired box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PAX5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [3]

TF Protein Name

 Paired box protein Pax-5 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Paired box protein Pax-5 (PAX5) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [3]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in megakaryocytes condition [14]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of CACNA1A gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

       Transcriptional Phenomenon2

 Direct binding to CACNA1A gene [4]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Embryo; Liver; Lung; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        IRF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [2]

TF Protein Name

 Interferon regulatory factor 4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 4 (IRF4) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [4]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in health condition [12]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of CACNA1A gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

TF Superclass5: alpha-Helices exposed by beta-structures

      Class5.1: MADS box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        MEF2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [3]

TF Protein Name

 Myocyte-specific enhancer factor 2A Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to CACNA1A gene in glioblastoma multiforme condition [6]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of CACNA1A gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [1]

TF Protein Name

 Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

 Breast; Bronchus; Ovary

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

        GRHL3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [2]

TF Protein Name

 Grainyhead-like protein 3 homolog Transcription Factor Info

Tissue

 Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNA1A gene [2]

TF Protein Name

 Nuclear factor 1 C-type Transcription Factor Info

Tissue

 Blood; Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear factor 1 C-type (NFIC) can directly bind to the CACNA1A gene, which in turn affects the expression or function of the drug transporter Voltage-gated calcium channel alpha Cav2.1.
References
1 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-302. (ID:ENSG00000141837)
4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5 Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network. Mol Metab. 2021 Nov;53:101313.
6 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
7 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
8 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
9 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
10 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
11 Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency. Commun Biol. 2022 Aug 2;5(1):779.
12 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
13 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
14 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

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