General Information of Drug Transporter (DT)
DT ID	DTD0518 Transporter Info
Gene Name	CACNA1A
Protein Name	Voltage-gated calcium channel alpha Cav2.1
Gene ID	773
UniProt ID	O00555
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs2112460
Site of GPD	chr19:13479598 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	A=0.4217/2112 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Antidepressants	N.A.	Hypertension	Allele A is associated with increased response to antidepressants in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Antidepressants	N.A.	Major Depressive Disorder	Allele A is associated with increased response to antidepressants in people with Depressive Disorder, Major as compared to allele G.		[ 1]
Antidepressants	N.A.	Major Depressive Disorder	Correlated with the increased drug response in patients (compare with allele G)		[ 1]
Genotype AA	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antidepressants	N.A.	Major Depressive Disorder	Patients with the AA genotype and major depressive disorder may have increased response to antidepressants compared to patients with the AG and GG genotypes. Other factors may affect response to antidepressants.		[ 1]
Genotype AG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antidepressants	N.A.	Major Depressive Disorder	Patients with the AG genotype and major depressive disorder may have increased response to antidepressants compared to patients with the GG genotype. Other factors may affect response to antidepressants.		[ 1]
Genotype GG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antidepressants	N.A.	Major Depressive Disorder	Patients with the GG genotype and major depressive disorder may have decreased response to antidepressants compared to patients with the AA and AG genotypes. Other factors may affect response to antidepressants.		[ 1]
Genetic Polymorphism	rs2074880
Site of GPD	chr19:13261817 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>C
Minor Allele Frequency	A=0.7240/1432 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Hypertension	Allele A is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele C.		[ 2]
Genetic Polymorphism	rs10416717
Site of GPD	chr19:13410714 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G / A>T
Minor Allele Frequency	A=0.5390/1066 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Hypertension	Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele A.		[ 2]
Genetic Polymorphism	rs7254351
Site of GPD	chr19:13207166 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>T
Minor Allele Frequency	G=0.4910/971 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Hypertension	Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele T.		[ 2]
Genetic Polymorphism	rs2248069
Site of GPD	chr19:13334394 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G / C>T
Minor Allele Frequency	C=0.3540/700 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Hypertension	Allele T is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele C.		[ 2]
Genetic Polymorphism	rs16030
Site of GPD	chr19:13277090 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G
Minor Allele Frequency	A=0.8340/1650 (Global)
Allele A	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Antiepileptics	N.A.	Hypertension	Allele A is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele G.		[ 2]
References
1	Genome-wide association study of antidepressant response: involvement of the inorganic cation transmembrane transporter activity pathway. BMC Psychiatry. 2016 Apr 18;16:106.
2	Association study between polymorphisms in the CACNA1A, CACNA1C, and CACNA1H genes and drug-resistant epilepsy in the Chinese Han population. Seizure. 2015 Aug;30:64-9.

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