Drug Transporter (DT) Information

General Information of DT
DT ID DTD0481
Gene Name SLC9A1
Protein Name Sodium/hydrogen exchanger 1
Gene ID
6548
UniProt ID
P19634
TCDB ID
2.A.36.1.13
3D Structure

Crystal Structure

Crystallisation Method:X-ray

PDB ID:2YGG

Corresponding Chain:A

Sequence Length:622-689

Detail: Struture Info

Synonyms APNH; APNH1; LIKNS; NHE-1; NHE1; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; PPP1R143; SLC9A1; Solute carrier family 9 member 1
DT Family Monovalent Cation:Proton Antiporter-1 (CPA1) family ;
Tissue Specificity Kidney and intestine.
Function This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions.
Endogenous Substrate(s) Na+; H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/hydrogen exchanger 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/hydrogen exchanger 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/hydrogen exchanger 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/hydrogen exchanger 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/hydrogen exchanger 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/hydrogen exchanger 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/hydrogen exchanger 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/hydrogen exchanger 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/hydrogen exchanger 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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